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Autor:
Elizabeth A. Maher, Benjamin M. Ellingson, Sung Choe, Saewon Chun, Marta Penas-Prado, Hua Liu, Lori Steelman, Patrick Y. Wen, Jennifer Clarke, Ingo K. Mellinghoff, Katherine B. Peters, Robert J. Young, Shuchi Sumant Pandya, Min Lu, Timothy F. Cloughesy, Howard A. Burris, Macarena I. de la Fuente, Filip Janku, Kha Le, Gregory M. Cote, Islam Hassan
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 16
Clin Cancer Res
Clin Cancer Res
Purpose: Lower grade gliomas (LGGs) are malignant brain tumors. Current therapy is associated with short- and long-term toxicity. Progression to higher tumor grade is associated with contrast enhancement on MRI. The majority of LGGs harbor mutations
Autor:
Jennifer Bordeaux, Dustin McCurry, Arivarasan Karunamurthy, Lisa H. Butterfield, Rogerio I. Neves, Anil Pahuja, Matthew P. Holtzman, Beiru Chen, Jehovana Orozco Bender, Ahmad A. Tarhini, Yan Zang, Ju Young Kim, John M. Kirkwood, Yan Lin, Cindy Sander, Joseph J. Skitzki, IlaSri B. Summit, Marc S. Ernstoff, Christian Laing, Joseph J. Drabick, Yana G. Najjar, Huang Lin, Jennifer Tsau, Ghanashyam Sarikonda, Igor Puzanov, Hassane M. Zarour, Zeni Alfonso, Amy Rose, James F. Pingpank, Diwakar Davar
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 15
Purpose:Neoadjuvant immunotherapy may improve the clinical outcome of regionally advanced operable melanoma and allows for rapid clinical and pathologic assessment of response. We examined neoadjuvant pembrolizumab and high-dose IFNα-2b (HDI) therap
Autor:
David M. Hyman, Lynette M. Sholl, Katherine Kargus, Hebert Alberto Vargas, Ann E. Sisk, Elio Adib, James J. Harding, Solida Pruitt-Thompson, Krinio Giannikou, Jennifer Hedglin, Martin H. Voss, Khanh T. Do, Ketki Bhushan, Matthew I. Milstein, David J. Kwiatkowski, Gopa Iyer, Geoffrey I. Shapiro, Junko Tsuji, Katarzyna Klonowska
Publikováno v:
Clinical Cancer Research. 27:3845-3853
Purpose:This was a multicenter, histology-agnostic, single-arm prospective phase II trial of therapeutic activity of everolimus, an oral mTORC1 inhibitor, in patients with advanced solid tumors that harbored TSC1/TSC2 or MTOR mutations.Patients and M
Autor:
Agnes Østlie, Maren M. Sjaastad Andreassen, Somaye Y. Zare, Rebecca Rakow-Penner, Christopher C. Conlin, Joshua M. Kuperman, Pål Erik Goa, Grace S. Ahn, Ana E. Rodríguez-Soto, Michael E. Hahn, Boya Abudu, Tyler M. Seibert, Neil P. Jerome, Tone Frost Bathen, Anders M. Dale, Haydee Ojeda-Fournier, Igor Vidic, Anne M. Wallace
Publikováno v:
Clin Cancer Res
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 4
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 4
Purpose: Diffusion-weighted MRI (DW-MRI) is a contrast-free modality that has demonstrated ability to discriminate between predefined benign and malignant breast lesions. However, how well DW-MRI discriminates cancer from all other breast tissue voxe
Autor:
Hyungsuk Ko, Kyu-Hwan Jung, Eun Ji Lee, Myeung Ju Kim, Jaekyung Myung, Hyunho Park, Chang Won Jung, Yul Ri Chung, Bo Gun Jang, Bong Hee Park, Kyungdoc Kim, Jeonghyuk Park, Baek Hui Kim, Yeong Won Kim, Dong-Il Kim, Jeong Hwan Park, Jae Moon Gwak, Dong Youl Choi
Publikováno v:
Clinical Cancer Research. 27:719-728
Purpose: Gastric cancer remains the leading cause of cancer-related deaths in Northeast Asia. Population-based endoscopic screenings in the region have yielded successful results in early detection of gastric tumors. Endoscopic screening rates are co
Autor:
Jad Chahoud, Agda Karina Eterovic, Frederico O. Gleber-Netto, Priya Rao, Ming Guo, Magaly Martínez-Ferrer, Curtis R. Pickering, Randy A. Chu, Xin Lu, Barrett McCormick, Curtis A. Pettaway, Maggaret B. Morgan
Publikováno v:
Clinical Cancer Research. 27:2560-2570
Purpose: Penile squamous cell carcinoma (PSCC) is rare with limited treatment options. We report the first whole-exome sequencing (WES) analysis and compare the molecular landscape of PSCC with other squamous cell carcinomas (SCC), with the goal to i
Autor:
Marc Ladanyi, Bob T. Li, Jennifer Kherani, Elena Ivanova, Arrien A. Bertram, Ezra Y. Rosen, Elaine M. Kelley, Jieun Son, Marina S.D. Milan, Jaclyn F. Hechtman, Romel Somwar, Kevin Ebata, Alexander Drilon, Melissa Lynne Johnson, Sarah E. Clifford, Jenna E. Scanlon, Barry S. Taylor, Geoffrey R. Oxnard, Eric Gladstone, S Michael Rothenberg, Elizabeth Olek, Monika A. Davare, Binoj Nair, Pasi A. Jänne, Mika Lin, Lynette M. Sholl, Morana Vojnic, Dahlia Henry
Publikováno v:
Clin Cancer Res
Purpose: The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by gene fusion in 1%–2% of non–small cell lung cancers (NSCLC) and rarely in other cancer types. Selpercatinib is a highly selective RET kinase inhibitor that ha
Autor:
Lawrence H. Einhorn, Darren R. Feldman, M. Eileen Dolan, Omar El-Charif, Christian Kollmannsberger, Chunkit Fung, David J. Vaughn, Robert J. Hamilton, Heather E. Wheeler, Lois B. Travis, Matthew Trendowski
Publikováno v:
Clin Cancer Res
Purpose: Cisplatin is a first-line chemotherapeutic for many cancers, but causes neurotoxicity including hearing loss, tinnitus, and peripheral sensory neuropathy. However, no study has comprehensively characterized risk factors for developing multip
Autor:
Afaf Abed, Leslie Calapre, Jenny H. Lee, Gabriela Marsavela, Michael Millward, Matteo S. Carlino, Sarah-Jane Dawson, Benhur Amanuel, Elin S. Gray, Michelle R. Pereira, Tarek Meniawy, Richard A. Scolyer, Anna L. Reid, Muhammad A. Khattak, Stephen Q. Wong, Alexander M. Menzies, Cleo Robinson, Lydia Warburton, Ashleigh C. McEvoy, Shahneen Sandhu, Georgina V. Long, Melanie Ziman, Helen Rizos
Publikováno v:
Clinical Cancer Research. 26:5926-5933
Purpose: We evaluated the predictive value of pretreatment ctDNA to inform therapeutic outcomes in patients with metastatic melanoma relative to type and line of treatment. Experimental Design: Plasma circulating tumor DNA (ctDNA) was quantified in 1
Autor:
Daniel W. Sherbenou, Thomas G. Martin, Olivia Perez De Acha, Byron Hann, Blake T. Aftab, Megan Murnane, Yang Su, Jeffery L. Wolf, Shelby C. Bearrows, Bin Liu, Christopher R. Behrens
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 26, iss 22
Clin Cancer Res
Clin Cancer Res
Purpose: New therapies have changed the outlook for patients with multiple myeloma, but novel agents are needed for patients who are refractory or relapsed on currently approved drug classes. Novel targets other than CD38 and BCMA are needed for new