Zobrazeno 1 - 7
of 7
pro vyhledávání: ''
Autor:
Konstantin Penkov, Taofeek K. Owonikoko, Peter M. Ellis, Bruce A. Bach, Anne Sibille, Vasudha Sehgal, Choon Hee Son, Lei He, Jaimee Glasgow, Harry J.M. Groen, Junya Fujimoto, Patricia M. de Groot, Kingston Kang, Martin Dunbar, Lauren Averett Byers, Steven J. M. Gans, Dmitry Bentsion
Publikováno v:
Clinical Cancer Research, 27(14), 3884-3895. AMER ASSOC CANCER RESEARCH
Purpose: This study investigated the efficacy and safety of oral PARP inhibitor veliparib, plus carboplatin and etoposide in patients with treatment-naïve, extensive-stage small cell lung cancer (ED-SCLC). Patients and Methods: Patients were randomi
Autor:
Annemiek M E Walenkamp, Andrew B. Lassman, Christopher J. Walker, Andrea Califano, Yao Shen, Leah Henegar, Patrick Y. Wen, Sharon Tamir, Kai Li, Martin J. van den Bent, Morten Mau-Sørensen, Hua Chang, Michael Kauffman, Yosef Landesman, Mariano J. Alvarez, Adam L. Green, Sharon Sacham, Scott R. Plotkin
Publikováno v:
Clin Cancer Res
Clinical Cancer Research, 28(3), 452-460. American Association for Cancer Research Inc.
Clinical Cancer Research, 28(3). AMER ASSOC CANCER RESEARCH
Clinical Cancer Research, 28(3), 452-460. American Association for Cancer Research Inc.
Clinical Cancer Research, 28(3). AMER ASSOC CANCER RESEARCH
Purpose:Selinexor is an oral selective inhibitor of exportin-1 (XPO1) with efficacy in various solid and hematologic tumors. We assessed intratumoral penetration, safety, and efficacy of selinexor monotherapy for recurrent glioblastoma.Patients and M
Autor:
Kurt R. Zinn, Eben L. Rosenthal, Yolanda E. Hartman, Kiranya E. Tipirneni, Lindsay S. Moore, Esther de Boer, Jason M. Warram, William R. Carroll, Todd M. Stevens
Publikováno v:
Clinical Cancer Research, 23(16), 4744-4752. AMER ASSOC CANCER RESEARCH
Purpose: Comprehensive cervical lymphadenectomy can be associated with significant morbidity and poor quality of life. This study evaluated the sensitivity and specificity of cetuximab-IRDye800CW to identify metastatic disease in patients with head a
Autor:
John Gallon, Erick Loomis, Adriaan Vanderstichele, Angela Wilson, James Paul, Caroline Kreuzinger, James M. Flanagan, Dan Cacsire Castillo-Tong, Jalid Sehouli, Els M.J.J. Berns, Charlotte Wilhelm-Benartzi, Robert S. Brown, Hani Gabra, Kirsty Flower, Nadeem Siddiqui, Nahal Masrour, Alexander Hergovich, G. Bea A. Wisman, Paula Cunnea, Chail Koo, Elena Ioana Braicu, Ignace Vergote, Silvia Darb-Esfahani
Publikováno v:
Clinical Cancer Research, 23(9), 2213-2222. American Association for Cancer Research Inc.
Clinical Cancer Research, 23(9), 2213-2222. AMER ASSOC CANCER RESEARCH
Clinical Cancer Research, 23(9), 2213-2222. AMER ASSOC CANCER RESEARCH
Purpose: DNA damage repair can lead to epigenetic changes. DNA mismatch repair proteins bind to platinum DNA adducts and at sites of DNA damage can recruit the DNA methylating enzyme DNMT1, resulting in aberrant methylation. We hypothesised that DNA
Autor:
Attilio Guarini, Emanuele Angelucci, Annunziata De Luisi, Paolo Ditonno, Claudia Piccoli, Domenico Ribatti, Beatrice Nico, Ivana Catacchio, Franco Dammacco, Vitalba Ruggieri, Simona Berardi, Roberto Ria, Tiziana Annese, Maria Antonia Frassanito, Michele Moschetta, Simona Ruggieri, Carla Minoia, Angelo Vacca, Daniele Derudas, Antonella Caivano
Publikováno v:
Clinical Cancer Research; Vol 20
Purpose: To investigate the role of hypoxia-inducible factor-1α (HIF-1α) in angiogenesis and drug resistance of bone marrow endothelial cells of patients with multiple myeloma. Experimental Design: HIF-1α mRNA and protein were evaluated in patient
Autor:
Erik A.C. Wiemer, Walter J. Loos, Jaap Verweij, Martin N Fransson, Alex Sparreboom, An K.L. Reyners, Lena E. Friberg, Ugo De Giorgi, Karel Eechoute, Ron H.J. Mathijssen, Gaia Schiavon, Floris A. de Jong, Winette T. A. van der Graaf
Publikováno v:
Clinical Cancer Research, 18, 20, pp. 5780-5787
Clinical Cancer Research, 18, 5780-5787
Clinical Cancer Research, 18(20), 5780-5787. American Association for Cancer Research Inc.
Clinical Cancer Research, 18(20), 5780-5787. AMER ASSOC CANCER RESEARCH
Clinical Cancer Research, 18, 5780-5787
Clinical Cancer Research, 18(20), 5780-5787. American Association for Cancer Research Inc.
Clinical Cancer Research, 18(20), 5780-5787. AMER ASSOC CANCER RESEARCH
Purpose: Imatinib minimal (trough) plasma concentrations after one month of treatment have shown a significant association with clinical benefit in patients with gastrointestinal stromal tumors (GIST). Considering that a retrospective pharmacokinetic
Autor:
Angela Capriati, Emile E. Voest, Stephan A. Veltkamp, Ingeborg J. G. M. van den Heuvel, Els Witteveen, Fabio Animati, Jos H. Beijnen, Marja Voogel-Fuchs, Attilio Crea, Jan H.M. Schellens
Publikováno v:
Clinical Cancer Research, 14(22), 7535-7544. AMER ASSOC CANCER RESEARCH
Purpose: To investigate i.v. administration of delimotecan (MEN 4901/T-0128), a carboxymethyldextran polymer prodrug of the active camptothecin derivative T-2513, and to assess the maximum tolerated dose, safety profile, clinical pharmacology, and an