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Publikováno v:
Clinical Breast Cancer. 22:771-780
Considering old age and comorbidities, the actual benefit of chemotherapy in older patients with early triple-negative breast cancer (TNBC) remains uncertain. We aimed to select appropriate patients who could avoid chemotherapy in this population.A t
Autor:
Li Zhu, Shuning Ding, Ou Huang, Weiguo Chen, Yafen Li, Weilin Chen, Xiaosong Chen, Jiayi Wu, Mengdi Chen, Caijin Lin, Deyue Liu, Kunwei Shen, Lisa Andriani, Jianrong He
Publikováno v:
Clinical Breast Cancer. 22:e147-e156
BACKGROUND In human epidermal growth factor receptor 2 (HER2)-positive breast cancer, emerging evidence imply that clinical behaviors differ according to hormone receptor (HR) status. However, there is no conclusion about the relevance between estrog
Autor:
C. Meyer, Y. Fouché, Emmanuel Chamorey, M. Dejode, C. Bailleux, J. Haudebourg, Renaud Schiappa, Y. Delpech, Emmanuel Barranger
Publikováno v:
Clinical Breast Cancer. 22:121-126
Background Delays in initiating adjuvant chemotherapy after breast cancer surgery seems to have an impact on patients’ risk of relapse and their survival rate. The aim of this retrospective study was to identify factors delaying initiation of adjuv
Publikováno v:
Clinical Breast Cancer. 22:e232-e238
Objective To evaluate factors contributing to positive surgical margins associated with reflector guidance for patients undergoing breast conserving therapy for malignancy. Materials and Methods A retrospective IRB-approved review of our institutiona
Autor:
Julie Means-Powell, Luis Del Valle, Vandana G. Abramson, Claudia Sorrentino, Melinda Sanders, Ingrid A. Mayer, Debra A. Tonetti, Roohi Ismail-Khan, Samarpan Majumder, Richard M Lush, Lucio Miele
Publikováno v:
Clin Breast Cancer
Preclinical studies have demonstrated a complex cross-talk between Notch and estrogen signaling in ERα-positive breast cancer. Gamma-secretase inhibitors (GSIs) are investigational agents that block the cleavage and activation of Notch receptors. In
Publikováno v:
Clinical Breast Cancer. 22:170-177
Background Accurate assessment of the axillary lymph nodes (aLNs) in breast cancer patients is essential for prognosis and treatment planning. Current radiological staging of nodal metastasis has poor accuracy. This study aimed to investigate the mac
A Systematic Comparison of Overall Survival Between Men and Women With Triple Negative Breast Cancer
Autor:
Mohammad Muhsin Chisti, Swechchha Silwal, Geetha Krishnamoorthy, Siddhartha Yadav, Sumeet Kumar Yadav
Publikováno v:
Clinical Breast Cancer. 22:161-169
Introduction Triple-negative breast cancer (TNBC) in men is very rare. The clinical characteristics, prognostic factors, and overall survival of men with TNBC have not been characterized. Methods The study population consisted of men and women with a
Autor:
Ashley J. Schlafstein, Karen D. Godette, Shannon Kahn, Mylin A. Torres, Subir Goyal, Jolinta Lin, Trevor J. Royce, Sagar A. Patel, Yuan Liu
Publikováno v:
Clinical Breast Cancer. 22:127-135
Neoadjuvant chemotherapy (NAC) is increasingly used for operable breast cancer (BC). Appropriate radiation therapy (RT) fields (ie, whole breast [WB] ± regional nodal irradiation [RNI]) in patients who were clinically node positive (cN1) but convert
Autor:
Ursa Brown-Glaberman, Hannah M. Linden, Lynn Symonds, Jennifer M. Specht, Eve T. Rodler, Isaac C. Jenkins, Xiaoyu Chai, Georgiana K. Ellis, Pavani Chalasani, Jinny Riedel, Brenda F. Kurland, Julie Gralow, Alison Stopeck, Qian Wu, Vijayakrishna V K Gadi
Publikováno v:
Clin Breast Cancer
INTRODUCTION Neoadjuvant chemotherapy is standard treatment for locally advanced (LABC) or inflammatory breast cancer (IBC). We hypothesized adding sunitinib, a tyrosine kinase inhibitor with anti-tumor and anti-angiogenic activity, to an anthracycli
Publikováno v:
Clinical Breast Cancer. 22:e91-e100
Multiple factors influence the time elapsed between diagnosis of breast cancer and surgical extirpation of the primary tumor. The disease-free interval between resection of primary breast cancer and first evidence of recurrence is predictive of morta