Zobrazeno 1 - 10
of 520
pro vyhledávání: ''
Autor:
Li Zhu, Shuning Ding, Ou Huang, Weiguo Chen, Yafen Li, Weilin Chen, Xiaosong Chen, Jiayi Wu, Mengdi Chen, Caijin Lin, Deyue Liu, Kunwei Shen, Lisa Andriani, Jianrong He
Publikováno v:
Clinical Breast Cancer. 22:e147-e156
BACKGROUND In human epidermal growth factor receptor 2 (HER2)-positive breast cancer, emerging evidence imply that clinical behaviors differ according to hormone receptor (HR) status. However, there is no conclusion about the relevance between estrog
Autor:
Julie Means-Powell, Luis Del Valle, Vandana G. Abramson, Claudia Sorrentino, Melinda Sanders, Ingrid A. Mayer, Debra A. Tonetti, Roohi Ismail-Khan, Samarpan Majumder, Richard M Lush, Lucio Miele
Publikováno v:
Clin Breast Cancer
Preclinical studies have demonstrated a complex cross-talk between Notch and estrogen signaling in ERα-positive breast cancer. Gamma-secretase inhibitors (GSIs) are investigational agents that block the cleavage and activation of Notch receptors. In
A Systematic Comparison of Overall Survival Between Men and Women With Triple Negative Breast Cancer
Autor:
Mohammad Muhsin Chisti, Swechchha Silwal, Geetha Krishnamoorthy, Siddhartha Yadav, Sumeet Kumar Yadav
Publikováno v:
Clinical Breast Cancer. 22:161-169
Introduction Triple-negative breast cancer (TNBC) in men is very rare. The clinical characteristics, prognostic factors, and overall survival of men with TNBC have not been characterized. Methods The study population consisted of men and women with a
Autor:
Ashley J. Schlafstein, Karen D. Godette, Shannon Kahn, Mylin A. Torres, Subir Goyal, Jolinta Lin, Trevor J. Royce, Sagar A. Patel, Yuan Liu
Publikováno v:
Clinical Breast Cancer. 22:127-135
Neoadjuvant chemotherapy (NAC) is increasingly used for operable breast cancer (BC). Appropriate radiation therapy (RT) fields (ie, whole breast [WB] ± regional nodal irradiation [RNI]) in patients who were clinically node positive (cN1) but convert
Autor:
Ursa Brown-Glaberman, Hannah M. Linden, Lynn Symonds, Jennifer M. Specht, Eve T. Rodler, Isaac C. Jenkins, Xiaoyu Chai, Georgiana K. Ellis, Pavani Chalasani, Jinny Riedel, Brenda F. Kurland, Julie Gralow, Alison Stopeck, Qian Wu, Vijayakrishna V K Gadi
Publikováno v:
Clin Breast Cancer
INTRODUCTION Neoadjuvant chemotherapy is standard treatment for locally advanced (LABC) or inflammatory breast cancer (IBC). We hypothesized adding sunitinib, a tyrosine kinase inhibitor with anti-tumor and anti-angiogenic activity, to an anthracycli
Autor:
Amy Weise, Maureen G. Conlan, Steven Troy, Patricia LoRusso, Miriam Annett, Cynthia X. Ma, Neelima Vidula, Erika Hamilton, Ziyang Yu, Rebecca G. Bagley
Publikováno v:
Clinical Breast Cancer. 22:67-77
Introduction/Background This first-in-human, phase 1 study aimed to characterize the safety, tolerability, maximum tolerated dose (MTD), pharmacokinetic (PK) profile, and antitumor activity of RAD140, an oral selective androgen receptor (AR) modulato
Autor:
Carol Tweed, Nicholas Huerta, Lorraine Tafra, Rubie Sue Jackson, Charles Mylander, Martin Rosman, Laura Martino, Kip Waite, Elaine Lee
Publikováno v:
Clinical Breast Cancer. 21:e731-e737
Introduction With the advent of genomic assays, sentinel lymph node biopsy (SLNB) may be less impactful in determining adjuvant breast cancer therapy. We evaluated the influence of SLNB on adjuvant therapy recommendation when the Oncotype DX recurren
Autor:
Larisa M. Haupt, Gabrielle Bradshaw, K.M. Taufiqul Arif, Rachel K. Okolicsanyi, Philippa H. Youl, Robert A. Smith, Thanh Tan Nguyen, Lyn R. Griffiths
Publikováno v:
Clinical Breast Cancer. 21:e694-e703
Introduction Breast cancer (BC), a heterogeneous disease, features microRNA-related single nucleotide polymorphisms (miRSNPs) as underlying factors of BC development, thus providing targets for novel diagnostic and therapeutic strategies. This study
Publikováno v:
Clinical Breast Cancer. 21:e611-e617
Purpose : The breast-conserving surgery (BCS) rate of breast cancer patients in China is much lower than that in Europe and the United States. This study aims to identify factors affecting the choice of surgical modality following neoadjuvant chemoth
Autor:
Fei Ma, Yanxia Sun, Qing Li, Peng Yuan, Shanshan Chen, Jiayu Wang, Yang Luo, Ying Fan, Pei Yu, Binghe Xu, Yiqun Han, Ruigang Cai, Qiao Li, Pin Zhang
Publikováno v:
Clinical Breast Cancer. 21:e497-e505
Different clinicopathologic characteristics could contribute to inconsistent prognoses of small breast neoplasms (T1a/T1b). This study was done to conduct a retrospective analysis and establish a clinical prediction model to predict individual surviv