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Autor:
Lunhao Bai, Zhiming Lin, Yicheng Tian, Shang Piao, He Zhang, Ziyu Huang, Zihao Li, Jinghan Lu
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Cell Death Discovery
Cell Death Discovery
Instability and excessive use of the knee joint can cause osteoarthritis (OA). Reasonable exercise can enhance the stability of the knee joint and prevent and relieve the occurrence and development of OA. As a key switch for inflammation, P2X purinoc
Autor:
Federica Andreola, Paola Spitalieri, Annalucia Serafino, Mauro Cozzolino, Arianna Colini Baldeschi, Daniela Giovannini, Simona Rossi, Ewa K. Krasnowska, Federica Sangiuolo
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Cell Death Discovery
Cell Death Discovery
Over the last 20 years, the efforts to develop new therapies for Parkinson’s disease (PD) have focused not only on the improvement of symptomatic therapy for motor and non-motor symptoms but also on the discovering of the potential causes of PD, in
Autor:
Zhonghua Zhao, Huijuan Wu, Jinfang Bao, Jun Liu, Yili Fang, Nan Zhu, Chenyang Qi, Zhihuang Zheng, Chuanlei Li, Kexin Xu, Qing Yu
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Nod-like receptor protein 3 (NLRP3), as an inflammatory regulator, has been implicated in acute kidney injury (AKI). Failed recovery after AKI can lead to chronic kidney disease (CKD). However, the role of NLRP3 in the AKI-CKD transition is still unk
Autor:
Yao He, Jing Han, Minhu Chen, Ying Wang, Mudan Zhang, Zhuo Xie, Li Li, Shenghong Zhang, Lihui Lin, Gaoshi Zhou, Zhirong Zeng
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
The Hedgehog (Hh) signalling pathway plays a critical role in the growth and patterning during embryonic development and maintenance of adult tissue homeostasis. Emerging data indicate that Hh signalling is implicated in the pathogenesis of inflammat
Autor:
Federica Urciuolo, Federica Campanelli, Gioia Marino, Antonio de Iure, Maurizio Bossola, Veronica Ghiglieri, Giuseppina Natale, Valeria Calabrese, Paolo Calabresi, Barbara Picconi
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-6 (2021)
Cell Death Discovery
Cell Death Discovery
Patients affected by chronic kidney disease (CKD) have an increased risk of developing cognitive impairment. The cause of mental health disorders in CKD and in chronic hemodialysis patients is multifactorial, due to the interaction of classical cardi
Autor:
Xin Wang, Longyan Yang, Bin Cao, Ruili Yin, Lingling Wei, Jing Ke, Li-Jie Zhang, Dong Zhao, Yan Wang, Ying-Jun Zhu
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Cell Death Discovery
Cell Death Discovery
As a common chronic metabolic disease, the development of diabetes mellitus (DM) may also be accompanied by liver damage and inflammatory disorders. Sitagliptin is an inhibitor of dipeptidyl peptidase-4 (DPP4, also known as CD26), which is clinically
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Radiation-induced liver injury (RILI) is a major complication of radiotherapy during treatment for liver cancer and other upper abdominal malignant tumors that has poor pharmacological therapeutic options. A series of pathological changes can be indu
Autor:
Dajiang Liu, Hongtao Guo, Yongxiu Yang, Xiao Lv, Xuehan Bi, Xiaolei Liang, Lijuan Wang, Guang Yao
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Death Discovery
Cell Death Discovery
Ovarian cancer is a common gynecological malignant tumor with a high mortality rate and poor prognosis. There is inadequate knowledge of the molecular mechanisms underlying ovarian cancer. We examined the expression of methyltransferase-like 3 (METTL
Autor:
Shuang Shen, Li-Xin Xiang, Dong-Dong Fan, Meng-ting Jin, Tong Shao, Jian-Zhong Shao, Aifu Lin, Yuan-hui Li
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-16 (2021)
Mesenchymal stem cell (MSC) therapy has become a promising treatment for liver fibrosis due to its predominant immunomodulatory performance in hepatic stellate cell inhibition and fibrosis resolution. However, the cellular and molecular mechanisms un
Autor:
Tongguo Shi, Yuqi Chen, Yanjun Chen, Juntao Li, Jiayu Wang, Hongya Wu, Suhua Xia, Xueguang Zhang, Zhendong Yao, Linqing Sun, Weichang Chen, Jinghan Zhu
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
Cell Death Discovery
Cell Death Discovery
Negative immune checkpoint blockade immunotherapy has shown potential for multiple malignancies including colorectal cancer (CRC). B7-H5, a novel negative immune checkpoint regulator, is highly expressed in tumor tissues and promotes tumor immune esc