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of 229
pro vyhledávání: ''
Autor:
Guojing Li, Yu Lin, Yili Zhang, Nihao Gu, Bingxin Yang, Shan Shan, Na Liu, Jing Ouyang, Yisai Yang, Feng Sun, Hong Xu
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Cell Death Discovery
Cell Death Discovery
Endometriosis, a chronic disorder characterised by the presence of endometrial-like tissue outside the uterus, is associated with iron overload and oxidative stress in the lesion. Although it is well established that iron overload can trigger ferropt
Autor:
Park, Cheol Ho, Lee, Bin, Han, Myeonggil, Rhee, Woo Joong, Kwak, Man Sup, Yoo, Tae-Hyun, Shin, Jeon-Soo
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Cell Death Discovery
Cell Death Discovery
Sodium-glucose cotransporter 2 inhibitors, which are recently introduced as glucose-lowering agents, improve cardiovascular and renal outcomes in patients with diabetes mellitus. These drugs also have beneficial effects in various kidney disease mode
Autor:
Ni An, Zhenjie Li, Xiaodi Yan, Hainan Zhao, Yajie Yang, Ruling Liu, Yanyong Yang, Fu Gao, Bailong Li, Hu Liu, Hongbin Yuan
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-13 (2022)
Cell Death Discovery
Cell Death Discovery
The lung is one of the most sensitive tissues to ionizing radiation, thus, radiation-induced lung injury (RILI) stays a key dose-limiting factor of thoracic radiotherapy. However, there is still little progress in the effective treatment of RILI. Ras
Autor:
Deguang Zhang, Li Tao, Nizheng Xu, Xiaoxiao Lu, Jianle Wang, Gaofei He, Qinghu Tang, Kangmao Huang, Shuying Shen, Junjie Chu
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Cell Death Discovery
Cell Death Discovery
Papillary thyroid cancer (PTC) is a common endocrine tumor with a rapidly increasing incidence in recent years. Although the majority of PTCs are relatively indolent and have a good prognosis, a certain proportion is highly aggressive with lymphatic
Autor:
Li, Guoliang, Ma, Shuai, Wu, Quanyou, Kong, Defeng, Yang, Zhenrong, Gu, Zhaoru, Feng, Lin, Zhang, Kaitai, Cheng, Shujun, Tian, Yantao, Zhang, Wen
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-8 (2022)
Cell Death Discovery
Cell Death Discovery
Signet ring cell carcinoma (SRCC) has specific oncogenesis and phenotypic and treatment resistance heterogeneity. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. Tumor organoids have recentl
Autor:
Yan Chen, Danqi Chen, Ying Qin, Cheng Qiu, Yaoyao Zhou, Mengmeng Dai, Lulu Li, Qinsheng Sun, Yuyang Jiang
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Cell Death Discovery
Cell Death Discovery
Colorectal cancer (CRC) is one of the digestive tract malignancies whose early symptoms are not obvious. This study aimed to identify novel targets for CRC therapy, especially early-stage CRC, by reanalyzing the publicly available GEO and TCGA databa
Autor:
Fanglong Wu, Shimeng Wang, Qingxiang Zeng, Junjiang Liu, Jin Yang, Jingtian Mu, Hongdang Xu, Lanyan Wu, Qinghong Gao, Xin He, Ying Liu, Hongmei Zhou
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Cell Death Discovery
Cell Death Discovery
Cancer-associated fibroblasts (CAFs) are highly heterogeneous and differentiated stromal cells that promote tumor progression via remodeling of extracellular matrix, maintenance of stemness, angiogenesis, and modulation of tumor metabolism. Aerobic g
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Cell Death Discovery
Cell Death Discovery
The deubiquitinating enzyme USP15 is implicated in several human cancers by regulating different cellular processes, including splicing regulation. However, the underlying molecular mechanisms of its functional relevance and the successive roles in e
Autor:
Zhang, Haonan, He, Chengcheng, Guo, Xuxue, Fang, Yuxin, Lai, Qiuhua, Wang, Xinke, Pan, Xingzhu, Li, Haolin, Qin, Kaiwen, Li, Aimin, Liu, Side, Li, Qingyuan
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-9 (2022)
Cell Death Discovery
Cell Death Discovery
DDX39B (also called UAP56 or BAT1) which is a kind of DEAD-box family helicase plays pivotal roles in mRNA binding, splicing, and export. It has been found upregulated in many kinds of tumors as an oncogene. Nevertheless, the underlying molecular mec
Autor:
Shang-Ze Li, Ze-Yan Zhang, Jie Chen, Ming-You Dong, Xue-Hua Du, Jie Gao, Qi-Peng Shu, Chao Li, Xin-Yi Liang, Zhi-Hao Ding, Run-Lei Du, Junli Wang, Xiao-Dong Zhang
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Cell Death Discovery
Cell Death Discovery
Serum response factor (SRF) regulates differentiation and proliferation by binding to RhoA-actin-activated MKL or Ras-MAPK-activated ELK transcriptional coactivators, but the molecular mechanisms responsible for SRF regulation remain unclear. Here, w