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Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Death Discovery
Cell Death Discovery
Alzheimer’s disease (AD) is characterized by accumulation of senile amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles causing progressive loss of synapse and neuronal death. Out of the various neuron death modalities, autophagy and apopt
Autor:
Jan Rybniker, Hannah S. Eisfeld, Melanie Fritsch, Manolis Pasparakis, Sebastian J. Theobald, Sandra Winter, Jessica Gräb, Maximilian Koch, Hamid Kashkar, Christoph Hölscher, Isabelle Suárez
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Cell Death Discovery
Cell Death Discovery
Necrotic cell death represents a major pathogenic mechanism of Mycobacterium tuberculosis (Mtb) infection. It is increasingly evident that Mtb induces several types of regulated necrosis but how these are interconnected and linked to the release of p
Autor:
Huey-Jiun Ko, Chung-Hwan Chen, Chihuei Wang, Po-Hsu Chou, Cheng-Jung Ho, Tzu-Shao Liao, Xiang-Ren Zheng, Li-Ting Wang, Ru-Wei Lin
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Apoptosis induced by doxorubicin, bortezomib, or paclitaxel, targeting DNA, 26S proteasome, and microtubules respectively, was assessed in two osteosarcoma cells, p53 wild-type U2OS and p53-null MG63 cells. Doxorubicin-induced apoptosis only occurred
Autor:
Shun Deng, Shi-Ya Pu, De-Sheng Pei, Wan-Ping Bian, Phyllis R. Strauss, Shaolin Xie, Chao Wang
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Cell Death Discovery
Cell Death Discovery
MVP17 encodes a mitochondrial inner-membrane protein, and mutation of human MVP17 can cause mitochondria DNA depletion syndrome (MDDS). However, the underlying function of mpv17 is still elusive. Here, we developed a new mutant with mpv17 knockout by
Autor:
Peijia Lin, Yuanyuan Chen, Hongnian Chen, Min Yang, Yuanlin Ma, Xin Tian, Zijun Lin, Kaiyan Tao, Aolei Lin, Miaoqing He, Qinglin Ye, Xuefeng Wang
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
Cell Death Discovery
Cell Death Discovery
Epilepsy is a common nervous system disease, and the existing theory does not fully clarify its pathogenesis. Recent research suggests that intestinal microbes may be involved in the development of epilepsy, but which microbe is involved remains uncl
Autor:
Simona D'Aguanno, Elisabetta Valentini, Rino Ragno, Marta Di Martile, Donatella Del Bufalo, Stefania Garzoli, Manuela Sabatino
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Death Discovery
Cell Death Discovery
Essential oils (EOs) have been recently emerging for their promising biological activities in preventing tumorigenesis or progression of different tumor histotypes, including melanoma. In this study, we investigated the antitumor activity of a panel
Publikováno v:
Cell Death Discovery, Vol 6, Iss 1, Pp 1-8 (2020)
Cell Death Discovery
Cell Death Discovery
HIV is a retrovirus that infects CD4+ T lymphocytes in human beings and causes immunodeficiency. In the recent years, various therapies have been developed against HIV, including targeting the HIV specific protein, integrase, responsible for integrat
Autor:
Regina Sayarova, Emil Bulatov, Rimma N. Mingaleeva, Pavel B. Davidovich, Marina O. Gomzikova, Yuri Ignatyev, Regina R. Miftakhova, Nickolai A. Barlev, Albert A. Rizvanov, Alexey Petukhov
Publikováno v:
Cell Death Discovery, Vol 4, Iss 1, Pp 1-9 (2018)
Cell Death Discovery
Cell Death Discovery
Medicinal bioinorganic chemistry is a thriving field of drug research for cancer treatment. Transition metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target-specific t
Autor:
Rajagopal Raman, Debika Datta, Gaurav Verma, Preeti Khatri, Shibnath Mazumder, Dhira Rani Saha, Ambika Singh
Publikováno v:
Cell Death Discovery, Vol 4, Iss 1, Pp 1-13 (2018)
Cell Death Discovery
Cell Death Discovery
Mycobacterium fortuitum is a natural fish pathogen. It induces apoptosis in headkidney macrophages (HKM) of catfish, Clarias sp though the mechanism remains largely unknown. We observed M. fortuitum triggers calcium (Ca2+) insult in the sub-cellular
Autor:
Asha Shelly, Shibnath Mazumder, Bhabatosh Das, Tanmay Majumdar, Nidhi Srivastava, Archana Pant, Manmohan Kumar
Publikováno v:
Cell Death Discovery
Toll-like receptor 4 (TLR4) plays a critical role in host immunity against Gram-negative bacteria. It transduces signals through two distinct TIR-domain-containing adaptors, MyD88 and TRIF, which function at the plasma membrane and endosomes, respect