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Autor:
Peijia Lin, Yuanyuan Chen, Hongnian Chen, Min Yang, Yuanlin Ma, Xin Tian, Zijun Lin, Kaiyan Tao, Aolei Lin, Miaoqing He, Qinglin Ye, Xuefeng Wang
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
Cell Death Discovery
Cell Death Discovery
Epilepsy is a common nervous system disease, and the existing theory does not fully clarify its pathogenesis. Recent research suggests that intestinal microbes may be involved in the development of epilepsy, but which microbe is involved remains uncl
Autor:
Lunguang Yao, Dandan Li, Juan Xing, Zhongyu Qu, Jiawei Zhou, Qian Xu, Qian Ding, Yugang Guo, Fanghui Bai
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Cell Death Discovery
Cell Death Discovery
Ferroptosis is closely linked to various cancers, including lung adenocarcinoma (LUAD); however, the factors involved in the regulation of ferroptosis-related genes are not well established. In this study, we identified and characterized ferroptosis-
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Death Discovery
Cell Death Discovery
The mortality rate of ovarian cancer (OC) remains the highest among all gynecological malignancies. Platinum-based chemotherapies are effective in treating most OC cases. However, chemoresistance is still a major challenge for successful OC treatment
Autor:
Junni Wang, Jianghua Chen, Ying Wang, Huanhuan Zhu, Xi Yao, Yuan Yuan, Xianghui Fu, Weiqiang Lin, Yunjing Zhang, Yin-Wu Bao, Mengqiu Bai, Jianhua Mao, Xishao Xie, Yi Yang
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Cell Death Discovery
Cell Death Discovery
Demethylase Tet2 plays a vital role in the immune response. Acute kidney injury (AKI) initiation and maintenance phases are marked by inflammatory responses and leukocyte recruitment in endothelial and tubular cell injury processes. However, the role
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
Cell Death Discovery
Cell Death Discovery
Emerging evidence demonstrates that WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) participates into carcinogenesis and tumor progression. In this review article, we will describe the association between dysregulated WWP1 expression and cl
Autor:
Laura J. Jenkins, Ashleigh R Poh, W.D. Fairlie, Marco Evangelista, Erinna F. Lee, Srividya B. Balachander, John M. Mariadason, Trishe Leong, Megan O'Brien, Jonathan Cebon, Surein Arulananda, Justin Cidado, Thomas John, Marzena Walkiewicz
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Malignant pleural mesothelioma (MPM) is an aggressive cancer with treatment limited to Cisplatin and Pemetrexed chemotherapy. Recently, we showed that drugs targeting the BCL-2-regulated apoptosis pathway could kill MPM cell lines in vitro, and contr
Autor:
Sang-Hee Cho, Rashedunnabi Akanda, Kyung-Hwa Lee, Eun Gene Sun, Jun-Eul Hwang, Hyun-Jeong Shim, Ji-Na Choi, Ik-Joo Chung, Woo Kyun Bae, Mi-Ra Park
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Death Discovery
Cell Death Discovery
Galectin 3-binding protein (LGALS3BP, also known as 90K) is a multifunctional glycoprotein involved in immunity and cancer. However, its precise role in colon inflammation and tumorigenesis remains unclear. Here, we showed that Lgals3bp−/− mice w
Autor:
Yicheng Chen, Liya Wang, Huan Wang, Zeyi Lu, Hao Zhang, Liqun Xia, Mingchao Wang, Gonghui Li, Qiming Zheng, Lifeng Ding
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Death Discovery
Cell Death Discovery
Nerves are important pathological elements of the microenvironment of tumors, including those in pancreatic, colon and rectal, prostate, head and neck, and breast cancers. Recent studies have associated perineural invasion with tumor progression and
Autor:
Jun Liang, Shangshang Wang, Yilun Wang, Jinhua Xu, Jie Wang, Zhixiong Zhang, Mengmeng Xiang, Qian Chen
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Death Discovery
Cell Death Discovery
Our previous study demonstrated that azithromycin could promote alternatively activated (M2) macrophages under lupus conditions in vitro, which might be beneficial for lupus treatment. Thus, the aim of this study was to further confirm whether azithr
Autor:
Mingming Lv, Xiaobo Wang, Rongchuan Yue, Yulong Zhang, Qingqing Tan, Zaiyong Zheng, Dan Qin, Tao Wang, Houxiang Hu, Yu Luo
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Cell Death Discovery
Cell Death Discovery
The exact mechanism of myocardial hypertrophy has not been completely elucidated. NOD-like receptor protein 3 (NLRP3) and the pyroptotic cascade play a critical role in cardiac hypertrophy and inflammation. The myokine irisin can inhibit NLRP3 activa