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Autor:
H Fiegl, Lourdes Rocamora-Reverte, Walther Parson, Claudia Soratroi, Gerlinde Karbon, Haschka, Hubert Hackl, Andreas Villunger
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Breast cancer (BC) treatment frequently involves microtubule-targeting agents (MTAs), such as paclitaxel, that arrest cells in mitosis. Sensitivity to MTAs is defined by a subset of pro- and anti-apoptotic BCL2 family proteins controlling mitochondri
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
STEAP3 (Six-transmembrane epithelial antigen of the prostate 3, TSAP6, dudulin-2) has been reported to be involved in tumor progression in human malignancies. Nevertheless, how it participates in the progression of human cancers, especially HCC, is s
Autor:
Aleksandra Sobiborowicz, Dominika Nowis, Paweł Jabłoński, Agnieszka Borowiec, Anna A Marusiak, Alicja Mazan, Monika K. Prelowska, Dawid Mehlich, Adam Gorczyński, Ewa Iżycka-Świeszewska, Michał Łomiak, Łukasz M. Szewczyk, Dagmara Dymerska, Anna Mehlich
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory potential
Autor:
Yuan-Ting Kuo, Kai-Ti Lin, Yi-Hsiang Wang, Wen-Hung Kuo, Chia-Yi Shen, Lu-Hai Wang, Wen-Ching Wang, Yu-Ling Hsu, Sheng-Chieh Lin
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-8 (2021)
Cell Death & Disease
Cell Death & Disease
Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast ca
HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer
Autor:
Shenshen Wu, Xiaobo Li, Xinwei Zhang, Haitao Zhu, Qingtao Meng, Michael Aschner, Michela Relucenti, Bin Li, Jun Yun, Rui Chen, Jie Xu, Hongbao Yang, Giuseppe Familiari, Hao Sun
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Chimeric antigen receptor (CAR) - T cell therapy is a new class of cellular immunotherapies, which has made great achievements in the treatment of malignant tumors. Despite improvements in colorectal cancer (CRC) therapy, treatment of many patients f
Autor:
Tongyue Zhang, Xiaoping Chen, Yijun Wang, Danfei Liu, Meng Xie, Xiaoyu Ji, Mengyu Sun, Limin Xia, Bixiang Zhang, Wenjie Huang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Metastasis is the predominant reason for high mortality of hepatocellular carcinoma (HCC) patients. It is critical to explore the molecular mechanism underlying HCC metastasis. Here, we reported that transcription factor One Cut homeobox 2 (ONECUT2)
Autor:
Lin Zhang, Xiao-Bo Wang, Yong Liu, Zhi-Bin Yu, Xiang Zhou, Jie Yang, Bo Jiao, Yanqi Liu, Ru-Zhou Zhao, Shuai Jiang, Zhao Xingcheng
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Rapid adaptation to a hypoxic environment is an unanswered question that we are committed to exploring. At present, there is no suitable strategy to achieve rapid hypoxic adaptation. Here, we demonstrate that fasting preconditioning for 72 h reduces
Autor:
Salvatore Sciacchitano, Arianna Di Napoli, Benjamin Terrier, Carlo Capalbo, Frauke Goeman, Francesca De Nicola, Michela D'Ascanio, Alberto Ricci, Christian Napoli, Simona di Martino, Giulia Piaggio, Agostino Tafuri, Andrea Sacconi, Maurizio Fanciulli, Luisa de Latouliere, Darragh Duffy, Luciano De Biase, Andrea Negro, Valentina Salvati, Claudia De Vitis, Carla Mottini, Rita Mancini, Francesca Paolini, Giovanni Blandino, Paolo Anibaldi, Paolo Marchetti, Gennaro Ciliberto
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-14 (2021)
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2021, 12 (11), pp.1019. ⟨10.1038/s41419-021-04299-y⟩
Cell Death and Disease, 2021, 12 (11), pp.1019. ⟨10.1038/s41419-021-04299-y⟩
Cell Death & Disease
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2021, 12 (11), pp.1019. ⟨10.1038/s41419-021-04299-y⟩
Cell Death and Disease, 2021, 12 (11), pp.1019. ⟨10.1038/s41419-021-04299-y⟩
Cell Death & Disease
Clinical outcomes of COVID-19 patients are worsened by the presence of co-morbidities, especially cancer leading to elevated mortality rates. SARS-CoV-2 infection is known to alter immune system homeostasis. Whether cancer patients developing COVID-1
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Melanoma originates from melanin-producing cells called melanocytes. Melanoma poses a great risk because of its rapid ability to spread and invade new organs. Cellular metastasis involves alteration in the gene expression profile and their transforma
Autor:
Zheng Li, Zhe Xuan, Jialun Lv, Guangli Sun, Hao Xu, Diancai Zhang, Hao Fan, Zekuan Xu, Jiacheng Cao, Linjun Wang, Yiwen Xia, Sen Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Gastric cancer (GC) ranks the third among global cancer-related mortality, especially in East Asia. Angiogenesis plays an important role in promoting tumor progression, and clinical trials have demonstrated that anti-angiogenesis therapy is effective