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Autor:
Yu Gan, Guoyu Dai, Feng Ru, Zhi Chen, Xiang Chen, Bo Zhang, Yao He, Bingsheng Li, Weiping Xia
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-10 (2021)
Renal fibrosis is a common pathological process that occurs with diverse etiologies in chronic kidney disease. However, its regulatory mechanisms have not yet been fully elucidated. Ferroptosis is a form of non-apoptotic regulated cell death driven b
Autor:
Zhigang Zhang, Zhihuang Zheng, Zhonghua Zhao, Huijuan Wu, Chuanlei Li, Jun Liu, Guangze Shao, Kexin Xu, Jinqing Li
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Acute kidney injury (AKI) is associated with significant morbidity and its chronic inflammation contributes to subsequent chronic kidney disease (CKD) development. Yes-associated protein (YAP), the major transcriptional coactivator of the Hippo pathw
Autor:
Hideki Arimochi, Shin-ichi Tsukumo, Hisanori Uehara, Yuki Sasaki, Thiranut Jaroonwitchawan, Kunihiro Otsuka, Tomoko Kobayashi, Koji Yasutomo, Michittra Boonchan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
The sensing of various extrinsic stimuli triggers the receptor-interacting protein kinase-3 (RIPK3)-mediated signaling pathway, which leads to mixed-lineage kinase-like (MLKL) phosphorylation followed by necroptosis. Although necroptosis is a form of
Autor:
Gaia Spinetti, Mario Tirone, Pasquale Creo, Simona Greco, Matteo Carrara, Paola Fuschi, Davide Maselli, Carlo Gaetano, Massimiliano Mazzone, Biagina Maimone, Fabio Martelli, Christine Voellenkle, Germana Zaccagnini, Marialucia Longo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Hypoxia-induced miR-210 is a crucial component of the tissue response to ischemia, stimulating angiogenesis and improving tissue regeneration. Previous analysis of miR-210 impact on the transcriptome in a mouse model of hindlimb ischemia showed that
Autor:
Xiaoli Cheng, Yanxia Liu, Chenghui Yan, Dan Liu, Yaling Han, Xiaoxiang Tian, Haixu Song, Zhang Xiaolin
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
Phenotype switching of cardiac fibroblasts into myofibroblasts plays important role in cardiac fibrosis following myocardial infarction (MI). Cellular repressor of E1A-stimulated genes (CREG) protects against vascular and cardiac remodeling induced b
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Fulminant hepatitis (FH) is an incurable clinical syndrome where novel therapeutics are warranted. Withaferin A (WA), isolated from herb Withania Somnifera, is a hepatoprotective agent. Whether and how WA improves D-galactosamine (GalN)/lipopolysacch
Autor:
Chan Mo, Weichao Zhong, Lei Gao, Bin Liu, Zhiping Lv, Ting Zeng, Yuyao Chen, Shaohui Huang, Yuqi Lai, Chuying Zhou, Sha Huang, Guanghui Deng, Shuwen Xie, Weixin Yan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Liver fibrosis is a course of chronic liver dysfunction, can develop into cirrhosis and hepatocellular carcinoma. Inflammatory insult owing to pathogenic factors plays a crucial role in the pathogenesis of liver fibrosis. Indoleamine 2,3-dioxygenase
Autor:
Sicheng Li, Xiuwen Wu, Xuanheng Li, Jianan Ren, Zhiwu Hong, Xufei Zhang, Jie Wu, Qinjie Liu, Jun Chen, Yun Zhao
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-12 (2020)
Cell Death & Disease
Cell Death & Disease
Background: Intestinal ischemia reperfusion (I/R) injury is the important pathogenesis for acute intestinal barrier disruption. The STING signaling is associated with gut homeostasis and barrier integrity. However, the biological function and regulat
Autor:
Jie-hui Tan, Jia Xu, Guo-wei Zhang, Yang-chen Jin, Min Luo, Xue-mei Chen, Jun-ling Zeng, Lei Zhou, Shu-ji Li, Rong-chang Cao, Guo-dong Hu, Jin Jin, Jia-yu Lin, Zhao-chang Qi, Huo-ji Chen, Zhi-tao Zhou
Publikováno v:
Cell Death and Disease, Vol 11, Iss 11, Pp 1-13 (2020)
Cell Death & Disease
Cell Death & Disease
Treatment of acute pancreatitis (AP) and chronic pancreatitis (CP) remains problematic due to a lack of knowledge about disease-specific regulatory targets and mechanisms. The purpose of this study was to screen proteins related to endoplasmic reticu
Autor:
Wenjuan Zhang, Weihao Lin, Zhengyuan Xia, Lawei Yang, Xuenong Li, Gang Liu, Yahong Wang, Wei Zhang, Xiaomin Li
Publikováno v:
Cell Death and Disease, Vol 11, Iss 10, Pp 1-17 (2020)
Cell Death & Disease
Cell Death & Disease
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by chronic non-specific inflammation of the interstitial lung and extensive deposition of collagen fibers leading to destruction of lung function. Studies ha