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Autor:
Lei Wang, Weike Xie, Chaoxiang Lu, Wang Kai, Shiqi Liu, Qi Wang, Yongkang Pan, Yunhua Wu, Qi Gao
Publikováno v:
Cell Cycle
Gastric cancer (GC) is the most common gastrointestinal malignancy worldwide. However, the molecular mechanisms of the progression of GC are not fully understood. Ras-responsive element binding protein 1 (RREB1) is an oncogene in many types of cancer
Publikováno v:
Cell Cycle
Binding sites of the chromatin regulator protein CTCF function as important landmarks in the human genome. The recently characterized CTCF-binding sites at LINE-1 repeats depend on another repeat-regulatory protein CGGBP1. These CGGBP1-dependent CTCF
Publikováno v:
Cell Cycle
Increasing proofs have declared that liver cancer stem cells (CSCs) are the main contributors to tumor initiation, metastasis, therapy resistance, and recurrence of hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying CSCs reg
Autor:
James L. Manley, Yueh-Lin Tsai
Publikováno v:
Cell Cycle
Amyotrophic Lateral Sclerosis (ALS) is a deadly neuromuscular disorder caused by progressive motor neuron loss in the brain and spinal cord. Over the past decades, a number of genetic mutations have been identified that cause or are associated with A
Publikováno v:
Cell Cycle
In eukaryotic cells, changes in chromatin accessibility are necessary for chromatin to maintain its highly dynamic nature at different times during the cell cycle. Histone chaperones interact with histones and regulate chromatin dynamics. Facilitates
Publikováno v:
Cell Cycle
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Mineralocorticoid and androgen receptor antagonist, spironolactone, was recently identified as an inhibitor of nucleotide excision repair (NER), acting via induction of proteolysis of TFIIH component Xeroderma Pigmentosum B protein (XPB). This activi
Autor:
KS Lee, Shinseog Kim, Su Hyung Park, Minwoo Wie, Jun Hong Park, Seong-Jung Kim, Tae Moon Kim, Kyungjae Myung
Publikováno v:
Cell Cycle
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Centrosomes are the primary microtubule-organizing centers that are important for mitotic spindle assembly. Centrosome amplification is commonly observed in human cancer cells and contributes to genomic instability. However, it is not clear how centr
Autor:
Igor Kovalchuk, Olga Kovalchuk, Gerlinde A. S. Metz, Rocio Rodriguez-Juarez, Yaroslav Ilnytskyy, Roderick T. Bronson, Mieke Heyns, Bo Wang, Dongping Li, Youli Yao, Anna Kovalchuk
Publikováno v:
Cell Cycle
Glioblastoma is the most aggressive brain tumor. Although miR-141 has been demonstrated to primarily function as a tumor suppressor in numerous malignancies, including glioblastoma, the mechanisms involved remain poorly understood. Here, it is shown
Autor:
Anna Woloszynska, Rebecca D. Greenspan, Candace S. Johnson, Brittany L. Bunch, Dan Wang, Kristopher Attwood, Wiam Bshara, Angela Omilian, Qianya Qi, Swathi Ramakrishnan, Roberto Pili, Carl Morrison, Li Yan, Donald L. Trump, Nithya Krishnan
Publikováno v:
Cell Cycle
Intrinsic and/or acquired resistance to cisplatin is a significant obstacle in the treatment of muscle-invasive bladder cancer. p73, a p53 homolog and determinant of chemosensitivity, is rarely mutated in bladder cancer (BC). However p73 expression a
Autor:
Satoshi Tateishi, Igor B. Rogozin, Yang Yang, Vyacheslav Yurchenko, Anastasia Zlatanou, Yanzhe Gao, Cyrus Vaziri
Publikováno v:
Cell Cycle
Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin ligase RAD18 and its downstream effectors, the ‘Y-family’ Trans-Lesion Synthesis (TLS) DNA polymerases, confer DNA damage tolerance at the expense of DNA repl