Zobrazeno 81 - 90
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Autor:
Kung Chao Chang, Ruo Yu Chen, Yao Chang, Ya Ping Chen, Hui Chen Lin, Liang Yi Hung, Paul Chih-Hsueh Chen, Po Min Chiang, L. Jeffrey Medeiros
Publikováno v:
Cancer Science
Hodgkin lymphoma (HL) is composed of neoplastic Hodgkin and Reed‐Sternberg cells in an inflammatory background. The neoplastic cells are derived from germinal center B cells that, in most cases, are infected by Epstein‐Barr virus (EBV), which may
Autor:
Aeneas Kolev, Magnus Starkhammar, Linda Marklund, Lars-Olaf Cardell, Eric Hjalmarsson, Gregori Margolin, Eva Munck-Wikland, Susanna Kumlien Georén, Pedro Farrajota Neves da Silva, Åsa Kågedal, Alexandra Elliot, Krzysztof Piersiala
Publikováno v:
Cancer Science
Anticancer immunotherapies have revolutionized cancer management, yet the effect of systemic anti‐programmed cell death protein 1 (PD‐1) treatment is predominantly studied in tumor‐infiltrating lymphocytes (TILs). Its impact on PD‐1 expressin
Autor:
Yusuke Okuma, Yuki Nakagawa, Kazuo Kasahara, Makoto Nishio, Naoko Sueoka-Aragane, Satoshi Watanabe, Haruhiro Saito, Koichi Goto, Kenichi Chikamori, Tomohisa Kawakami
Publikováno v:
Cancer Science
IMpower132 explored the safety and efficacy of atezolizumab plus pemetrexed and platinum‐based chemotherapy as first‐line treatment for advanced non‐small‐cell lung cancer (NSCLC). Key eligibility criteria for the phase 3, open‐label, IMpow
Autor:
Ririno Honma, Naoya Sakamoto, Shoichi Ukai, Hideki Ohdan, Kazuhito Naka, Daiki Taniyama, Wataru Shimizu, Kenji Harada, Wataru Yasui, Yuji Takakura, Takao Hinoi, Ryota Maruyama
Publikováno v:
Cancer Science
5‐Fluorouracil (5‐FU) is one of the most frequently used pharmacological agents in the treatment of colorectal cancer (CRC). Resistance to chemotherapy is a major cause of treatment failure of CRC, and it is a well known fact that cancer stem cel
Autor:
Taichi Hagio, Seiichi Mori, Sayuri Amino, Takeshi Nakajima, Tetsuo Noda, Tomoko Kaneyasu, Seigo Nakamura, Masaaki Matsuura, Tomo Osako, Noriko Yaguchi, Toru Hirota, Eri Nakashima, Dai Kitagawa, Takayuki Ueno, Reiko Yoshida, Osamu Gotoh, Norio Tanaka, Shinji Ohno, Yoshio Miki, Shunji Takahashi
Publikováno v:
Cancer Science
Genes involved in the homologous recombination repair pathway—as exemplified by BRCA1, BRCA2, PALB2, ATM, and CHEK2—are frequently associated with hereditary breast and ovarian cancer syndrome. Germline mutations in the loci of these genes with l
Autor:
Makoto Urano, Toru Nagao, Kazuo Sakurai, Ryo Kawata, Kenji Okami, Kimihide Kusafuka, Ken-ichi Nibu, Tetsuro Onitsuka, Hiroshi Inagaki, Toshitaka Nagao, Ken Ichi Taguchi, Kiyoaki Tsukahara, Kaori Ueda, Nobuhiro Hanai, Naruhiko Morita, Yasushi Fujimoto, Daisuke Kawakita, Satoshi Kano, Takayuki Murase, Yuichiro Tada, Naohito Hato, Masato Nakaguro, Hidetaka Yamamoto, Naoki Otsuki
Publikováno v:
Cancer Science
Three pathological grading systems advocated by Perzin/Szanto, Spiro, and van Weert are currently used for adenoid cystic carcinoma (AdCC). In these systems, the amount or presence of the solid tumor component in AdCC specimens is an important index.
Autor:
Scott Cameron, Ayako Mitsuma, Yoichi Naito, Tomoya Shimokata, Yuichi Ando, Takeshi Tajima, Kae Ishihara, Nobuaki Matsubara, Yoshinori Imamura, Hironobu Minami, Kota Tokushige, Toshihiko Doi, Naomi Kiyota, Masanori Toyoda
Publikováno v:
Cancer Science
Spartalizumab is a humanized IgG4/κ mAb directed against human programmed cell death‐1 (PD‐1). In this phase I study, we investigated safety, pharmacokinetics, preliminary antitumor activity, and toxicity of spartalizumab in patients with advanc
Autor:
Hiroaki Matsumoto, Hideyasu Matsuyama, Yukimi Sakoda, Yoji Nagashima, Takahiro Sasaki, Koji Tamada, Shunsuke Goto, Jun‐ich Mori, Keishi Adachi
Publikováno v:
Cancer Science
Chimeric antigen receptor (CAR)‐T cell therapy has shown salient efficacy in cancer immunotherapy, particularly in the treatment of B cell malignancies. However, the efficacy of CAR‐T for solid tumors remains inadequate. In this study, we display
Autor:
Tom Wei-Wu Chen, Herbert H. Loong, Sze Huey Tan, Alex K.C. Leung, Richard Quek, Chih Chi Chang, Angela Pang, Myo Myint Maw, Takeshi Hirose, Makoto Endo, Akira Kawai, Mark E. Puhaindran, Virote Sriuranpong, Siyamol Mingmalairak, Mohamad Farid, Jeffrey C.H. Chan, Wei Lin Goh, Roger K.C. Ngan
Publikováno v:
Cancer Science
Angiosarcoma (AS) is a rare disease with a dismal prognosis. The treatment landscape and prognostic factors for advanced AS, including locally advanced, unresectable, and metastatic disease remain elusive. The Asian Sarcoma Consortium is an internati
Publikováno v:
Cancer Science
Bladder cancer (BC) is one of the most commonly diagnosed cancers globally. Recently, circular RNAs (circRNAs) have been revealed to participate in BC progression with diverse mechanisms. However, mechanisms of circ_100984 in BC have not been determi