Zobrazeno 1 - 10
of 615
pro vyhledávání: ''
Autor:
Kenji Wakai, Tetsuya Mizoue, Shiori Tanaka, Tetsuhisa Kitamura, Kotaro Ozasa, Shuhei Nomura, Keitaro Matsuo, Shizuka Sasazuki, Michihiro Muto, Hidekazu Suzuki, Taichi Shimazu, Tomio Nakayama, Yingsong Lin, Norie Sawada, Motoki Iwasaki, Tetsuya Otani, Keitaro Tanaka, Isao Oze, Atsuko Sadakane, Shoichiro Tsugane, Sarah Krull Abe, Mariko Naito, Eiko Saito, Yoshikazu Nishino, Yoshitaka Tsubono, Chisato Nagata, Yumi Sugawara, Keiko Wada, Ayami Ono, Taiki Yamaji, Takashi Tamura, Ichiro Tsuji, Hidemi Ito, Yuri Kitamura, Hadrien Charvat, Akiko Tamakoshi, Mai Utada, Mamami Inoue
Publikováno v:
Cancer Science
The association between alcohol intake and stomach cancer risk remains controversial. We undertook a pooled analysis of data from six large‐scale Japanese cohort studies with 256 478 participants on this topic. Alcohol intake as ethanol was estimat
Autor:
Yosuke Iwatate, Yuki Nakamura, Hiroki Nagase, Yasutoshi Tatsumi, Isamu Hoshino, Makiko Itami, Hajime Yokota, Osamu Shimozato, Naoki Kuwayama, Yasukuni Mori, Fumitaka Ishige, Takashi Uno
Publikováno v:
Cancer Science
Tumor mutational burden (TMB) is gaining attention as a biomarker for responses to immune checkpoint inhibitors in cancer patients. In this study, we evaluated the status of TMB in primary and liver metastatic lesions in patients with colorectal canc
Autor:
Atsushi Nakamura, Shunsuke Teraoka, Naohisa Matsumoto, Kazuhiko Nakagawa, Akito Hata, Satoshi Ikeda, Nobuyuki Yamamoto, Motohiro Tamiya, Shinya Sakata, Satoru Miura, Kentaro Ito, Hiroshige Yoshioka, Yoshimasa Shiraishi, Shota Omori, Junko Tanizaki, Koji Haratani, Hisako Yoshida, Kohei Otsubo
Publikováno v:
Cancer Science
Considering the increasing number of identified driver oncogene alterations, additional genetic tests are required to determine the treatment for advanced non‐small‐cell lung cancer (NSCLC). Next‐generation sequencing can detect multiple driver
Autor:
Isamu Okamoto, Tatsuo Ohira, Nobuyuki Yamamoto, Hidehito Horinouchi, Toyoaki Hida, Shinji Atagi, Tatsuro Fukuhara, Miyako Satouchi, Kazuma Kishi, Shunichi Sugawara, Shi Rong Han, Hideo Saka, Victoria Ebiana, Katsuyuki Hotta, Keisuke Aoe, Kazuhiko Nakagawa, Hiroshi Sakai, Hiroaki Okamoto, Kazuo Noguchi, Kaname Nosaki, Atsushi Horiike, Shigeki Umemura, Toshiaki Takahashi, Takayasu Kurata, Nobuyuki Katakami, Akimasa Sekine
Publikováno v:
Cancer Science
Cancer Sci
Cancer Sci
This prespecified subanalysis of the global, randomized controlled phase III KEYNOTE‐024 study of pembrolizumab vs chemotherapy in previously untreated metastatic non‐small‐cell lung cancer without EGFR/ALK alterations and a programmed death li
Autor:
Shingo Yamamoto, Yusuke Yamada, Yoshie Yoshikawa, Akihiro Kanematsu, Mitsuru Emi, Yukako Nakanishi-Shinkai, Karel de Groot, Tomoko Hashimoto-Tamaoki, Jan Smout, Suvi Savola, Michio Nojima, Lilit Atanesyan, Masaki Ohmuraya
Publikováno v:
Cancer Science
Precise quantification of copy‐number alterations (CNAs) in a tumor genome is difficult. We have applied a comprehensive copy‐number analysis method, digital multiplex ligation‐dependent probe amplification (digitalMLPA), for targeted gene copy
Autor:
Ryoko Katagiri, Michio Sato, Hiroaki Ikematsu, Yasuo Kakugawa, Koji Hosomi, Kinichi Hotta, Kenji Watanabe, Michihiro Mutoh, Rieko Kanehara, Takahisa Matsuda, Jun Kunisawa, Taiki Yamaji, Motoki Iwasaki, Yuta Tsunematsu, Keiji Wakabayashi
Publikováno v:
Cancer Science
Escherichia coli containing polyketide synthase in the gut microbiota (pks + E coli) produce a polyketide‐peptide genotoxin, colibactin, and are suspected to play a role in the development of colorectal neoplasia. To clarify the role of pks + E col
Autor:
Danhua Wang, Jinku Zhang, Bobo Li, Dezhi Cheng, Minke Shi, Weiran Wang, Tonghui Ma, Sizhen Wang, Dongxiao Lv
Publikováno v:
Cancer Science
Fusion of RET with different partner genes has been detected in papillary thyroid, lung, colorectal, pancreatic, and breast cancer. Approval of selpercatinib for treatment of lung and thyroid cancer with RET gene mutations or fusions calls for studie
Autor:
Masahiko Mori, Takayuki Nagasawa, Takayuki Enomoto, Toru Sugiyama, Yuki Inokuchi, Satoru Nagase, Shoji Kamiura, Tetsuro Oishi, Shinichi Komiyama, Tadahiro Shoji, Masakazu Abe, Nobuhiro Takeshima, Aikou Okamoto
Publikováno v:
Cancer Science
We investigated the efficacy and safety of further bevacizumab therapy in patients with platinum‐resistant ovarian cancer whose disease had progressed after bevacizumab plus chemotherapy. In this multicenter, open‐label, phase II trial (JGOG3023)
Autor:
Takuto Nakashima, Dai Maruyama, Ryo Kamei, Kana Miyazaki, Kensei Tobinai, Hideki Tsujimura, Makoto Yoshimitsu, Noriko Fukuhara, Satoshi Osaga, Shinsuke Iida, Kunihiro Tsukasaki, Aya Sakabe, Hirokazu Nagai, Norifumi Tsukamoto, Masaki Ri, Ken-ichi Miyamoto, Masahiro Tohkin
Publikováno v:
Cancer Science
Bortezomib (Btz) shows robust efficacy in patients with multiple myeloma (MM); however, some patients experience suboptimal responses and show specific toxicities. Therefore, we attempted to identify specific HLA alleles associated with Btz‐related
Autor:
E Sun Paik, Eun Jin Heo, Jeong-Won Lee, Jong-Won Kim, Chel Hun Choi, Byoung-Gie Kim, Jae Hoon Kim, Jae Weon Kim, Sang Yoon Park, Yong-Man Kim
Publikováno v:
Cancer Science
This study was performed to investigate the prevalence, clinical characteristics, and treatment response according to BRCA1 and BRCA2 (BRCA) mutations in Korean patients with epithelial ovarian cancer (EOC). Two‐hundred and ninety‐eight Korean wo