Zobrazeno 1 - 10
of 51
pro vyhledávání: '"35"'
Publikováno v:
Cancer Research. 80:P5-04
Though CTLA4 expression was reported in various tumor types, expression of CTLA4 is not well known in breast cancers, especially HER2-positive breast cancers. TILs level has significant role in treatment response and prognosis in HER2-positive breast
Autor:
Sheldon Feldman, Matthew Maurer, S Refice, Bret Taback, Kevin Kalinsky, Dawn L. Hershman, Katherine D. Crew, Hanina Hibshoosh, Eileen P. Connolly, Tian Zheng
Publikováno v:
Cancer Research. 75:P6-12
Background: Laboratory and population studies demonstrate that metformin offers a beneficial breast cancer (BC) effect. In vitro, metformin has been shown to induce cycle cycle arrest. In a pre-surgical metformin trial of overweight/obese, multi-ethn
Autor:
Kevin Kalinsky, DL Hershman, MM Maurer, B Taback, Katherine D. Crew, Sheldon Feldman, Hanina Hibshoosh, S Refice, Tian Zheng, Tao Su
Publikováno v:
Cancer Research. 73:P4-15
Background: Laboratory and population studies demonstrate that metformin offers a beneficial breast cancer (BC) effect through reduction of serum insulin levels and changes in cellular protein synthesis and growth, such as AMPK pathway signaling. In
Autor:
Yoonhee Choi, Sung Sook Lee, Soo Young Chung, Yoo Sang Yoon, Ha Young Lee, Jae Hyun Kim, Bong-Gun Seo, Kyung A Kwon, Hee Sam Na
Publikováno v:
Cancer Research. 77:4664-4664
Purposes Lung squamous cell carcinoma (SQCC) is the second-largest histological subtype of non-small cell lung cancer, but relatively few biomarkers are available compared to adenocarcinoma. Recently, chemokines and their receptors have been suggeste
Autor:
Shibu Thomas, Ryan P. McMullin, Daniel Sondheim, Gormley Michael, Deborah Ricci, Corey Eva, Lisha G. Brown, Holly M. Nguyen, Yashoda Rajpurohit, Himanshu Gupta
Publikováno v:
Cancer Research. 76:3074-3074
Results from clinical and preclinical investigations suggest potential survival benefits from more aggressive early treatment of some patients. Our objective was to evaluate in vivo the efficacy of adding docetaxel (DOC) or ARN509, alone or in combin
Autor:
Florian Bochen, Matthias Wagner, Mariz Kasoha, Barbara Linxweiler, Erich-Franz Solomayer, Merle Doerk, Maximilian Linxweiler, Z Takacs, MP Radosa, Julia Caroline Radosa, Rainer M. Bohle
Publikováno v:
Cancer Research. 80:P1-10
Background Chromosome 3q26 amplifications have been shown to represent a frequent alteration in various cancer entities including breast cancer. SEC62 - a 3q26 encoded gene - was identified as a potential oncogene and tumor-driver-gene for the pathog
Publikováno v:
Cancer Research. 73:B23-B23
Introduction: Tumor associated macrophages (TAMs) play a pivotal role in tumoriogenesis of human cancers, including advanced thyroid cancers. A recent study demonstrated that the increased density of TAMs was positively associated with lymph node (LN
Autor:
Yacine Bareche, Janina Kulka, L Pusztai, D. Larsimont, C Desmedt, Laurence Buisseret, Christos Sotiriou, K Willard-Gallo, Soizic Garaud, Christos Hatzis, Borbála Székely, Roberto Salgado, G. Van den Eynden, Marcell A Szász
Publikováno v:
Cancer Research. 79:PD5-10
Introduction While immune infiltrates have already been extensively characterized in primary tumors (P), data on breast cancer metastases (M) remains limited. To this end we quantified and qualified the immune cells in a unique cohort of multiple mat
Autor:
Ji-Youn Han, Mireille Cantarini, Nisha Kurian, Aleksandra Markovets, Ryan J. Hartmaier, Pasi A. Jänne, Byoung Chul Cho
Publikováno v:
Cancer Research. 81:CT127-CT127
Background/Purpose Following disease progression on osimertinib, a third generation (3G), irreversible, oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI), ≤22% of patients (pts) with EGFR mutation positive (EGFRm) non-small
Autor:
Diane L. Rossi, Thomas M. Cardillo, Ken Chang, DM Goldenberg, EA Rossi, Robert M. Sharkey, Ali Mostafa, Rongxiu Li
Publikováno v:
Cancer Research. 77:P6-14
Bispecific antibodies (bsAbs) for redirecting T cells to cancers have shown promise in both pre-clinical and clinical studies. However, clinical success has been minimal for solid cancers to-date. Previously, we reported highly effective T-cell redir