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Autor:
Sonam Bhatia, Melissa Kramer, Suzanne Russo, Payal Naik, Gayatri Arun, Kyle Brophy, Peter Andrews, Cheng Fan, Charles M. Perou, Jonathan Preall, Taehoon Ha, Dennis Plenker, David A. Tuveson, Arvind Rishi, J Erby Wilkinson, W. Richard McCombie, Karen Kostroff, David L. Spector
Publikováno v:
Cancer Res
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with poor patient outcomes, highlighting the unmet clinical need for targeted therapies and better model systems. Here, we developed and comprehensively characterized a diver
Autor:
J. Qiu, Umesh Bhanot, John T. Poirier, Yingqian Zhan, Elisa de Stanchina, Viola Allaj, Hirokazu Taniguchi, Fathema Uddin, Travis J. Hollmann, Jordana Ray-Kirton, Metamia Ciampricotti, Andrew Chow, Marina Asher, Richard Koche, Álvaro Quintanal-Villalonga, Jacklynn V. Egger, Yuan Hao, Joseph M. Chan, Shweta S Chavan, Charles M. Rudin, Michael H.A. Roehrl, Triparna Sen, Michael Offin, Irina Linkov, Nisargbhai S. Shah, P. Manoj
Publikováno v:
Cancer Res
Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early metastasis and extreme lethality. The backbone of SCLC treatment over the past several decades has been platinum-based doublet chemotherapy, with the recent addition of
Autor:
Yinzhong Shang, Linlin Yan, Mingming Wu, Yong Zhu, Tao Zhu, Hui Yuan, Xiao Zhang, Zhengsheng Wu, Qianying Guo, Peter E. Lobie, Xin Ma
Publikováno v:
Cancer Research. 82:391-405
Estrogen receptor alpha (ERα) plays a vital role in the development of normal breast tissue and in breast cancer. By cross-analyzing The Cancer Genome Atlas (TCGA) database, ERα-regulated long noncoding RNA 1 (ERLC1) was identified as a long noncod
Autor:
Emanuela Ercolano, Bora Agit, Emmanuel Atangana Maze, David A Hilton, Sylwia Ammoun, Shona Reeves, Robert D Belshaw, Kathreena M Kurian, C. Oliver Hanemann, David Parkinson, Liyam Laraba
Publikováno v:
Cancer Research. 82:235-247
Deficiency of the tumor suppressor Merlin causes development of schwannoma, meningioma, and ependymoma tumors, which can occur spontaneously or in the hereditary disease neurofibromatosis type 2 (NF2). Merlin mutations are also relevant in a variety
Publikováno v:
Cancer Research. 82:320-333
Basal-like breast cancer is the most aggressive breast cancer subtype with the worst prognosis. Despite its high recurrence rate, chemotherapy is the only treatment for basal-like breast cancer, which lacks expression of hormone receptors. In contras
Autor:
Man Xu, Tyler Teceno, Pasi A. Jänne, Anika E. Adeni, Paul Kirschmeier, Timothy Lopez, Jens Köhler, Emily S. Chambers, Brittaney A Leeper, Mari Kuraguchi, Elena Ivanova, Arrien A. Bertram, Cloud P. Paweletz, Yoshinobu Shiose, Yutong Zhao, C. Yu, Yasuki Kamai, Luke J. Taus, Kenneth H. Ngo, Qing Zeng, Prafulla C. Gokhale, Heidi M. Haikala, Yang Qiu, Pinar O. Eser
Publikováno v:
Cancer Research. 82:130-141
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) are the standard-of-care treatment for EGFR-mutant non–small cell lung cancers (NSCLC). However, most patients develop acquired drug resistance to EGFR TKIs. HER3 is a unique
Autor:
Katarzyna Zawieracz, Mark A. Eckert, Janna Heide, Mengjie Chen, Ernst Lengyel, Lei Huang, Ahmed Ashour Ahmed, Melissa Javellana, David Chapel, Elizabeth Stock, Sarah Ashley, S. Diane Yamada, Melanie Weigert, Ricardo R. Lastra
Publikováno v:
Cancer Res
The growing use of neoadjuvant chemotherapy to treat advanced stage high-grade serous ovarian cancer (HGSOC) creates an opportunity to better understand chemotherapy-induced mutational and gene expression changes. Here we performed a cohort study inc
Autor:
Amber S. Moody, Juan D. Rojas, Paul A. Dayton, Nikhila Sultanpuram, Ellie McCabe, Hossein Sendi, Liantao Li, Jiajie Zhang, Mengying Hu, Leaf Huang, Jie Wang, Mostafa Yazdimamaghani, Andrew Wang, Amanda Graboski
Publikováno v:
Cancer Res
Liver metastasis is a leading cause of cancer morbidity and mortality. Thus, there has been strong interest in the development of therapeutics that can effectively prevent liver metastasis. One potential strategy is to utilize molecules that have bro
Publikováno v:
Cancer Res
Neoadjuvant immunotherapy, given before surgical resection, is a promising approach to develop systemic antitumor immunity for the treatment of high-risk resectable disease. Here, using syngeneic and orthotopic mouse models of triple-negative breast
Autor:
Becky K. C. Chan, Stephanie Ma, Hoi Yee Chu, Koon Ho Wong, Cindy S.W. Tong, Gigi C. G. Choi, Maggie S. H. Cheung, Tin Lok Wong, Yuanhua Huang, Feng Xu, John H. C. Fong, Alan S.L. Wong, Lakhansing Pardeshi, Man Tong, Kylie Hin-Man Mak
Publikováno v:
Cancer Research. 81:6219-6232
Systematic testing of existing drugs and their combinations is an attractive strategy to exploit approved drugs for repurposing and identifying the best actionable treatment options. To expedite the search among many possible drug combinations, we de