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Autor:
Rami I. Aqeilan, Maria Sundvall, Marius Sudol, Johan Lundin, Anna Korhonen, Heikki Joensuu, Jorma Isola, Eugenio Gaudio, Valentina Donati, Carlo M. Croce, Klaus Elenius, Milena S. Nicoloso
Publikováno v:
Cancer Research. 67:9330-9336
WWOX, WW domain-containing oxidoreductase, is a tumor suppressor that is altered in many human cancers, including breast cancer. Wwox interacts with the ErbB4 receptor, reduces nuclear translocation of the cleaved intracellular domain of ErbB4, and i
Autor:
Jianjun Liu, Fergus J. Couch, Sofia Khan, Andrew Collins, Diana Eccles, Sue Gerty, William J. Tapper, Sajjad Rafiq, Carl Blomqvist, Ioannis Politopoulos, Heli Nevanlinna
Publikováno v:
Cancer research. 73(6)
Genome-Wide Association Studies (GWAS) have begun to investigate associations between inherited genetic variations and breast cancer prognosis. Here, we report our findings from a GWAS conducted in 536 patients with early-onset breast cancer aged 40