Zobrazeno 1 - 10
of 252
pro vyhledávání: ''
Autor:
Kamal Chamoun, Elias Jabbour, Guillermo Garcia-Manero, Musa Yilmaz, Gautam Borthakur, Marina Konopleva, Nitin Jain, Courtney D. DiNardo, Kiran Naqvi, Farhad Ravandi, Tapan M. Kadia, Fleur M. Aung, Xuemei Wang, Hagop M. Kantarjian, Jorge E. Cortes, Naval Daver
Publikováno v:
Cancer. 125:3219-3224
BACKGROUND The combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has proven to be the most effective therapy for patients with acute promyelocytic leukemia (APL). The majority of the morbidity and mortality from APL therapy occ
Autor:
Gautam Borthakur, William Plunkett, Farhad Ravandi, Tapan M. Kadia, Barry D. Anderson, Naval Daver, Jane Waukau, Guillermo Garcia-Manero, Elias Jabbour, Monica Kwari, Kenzo Iizuka, Cheng Jin, Hagop M. Kantarjian, Courtney D. DiNardo, Chun Zhang, Nitin Jain
Publikováno v:
Cancer. 125:1665-1673
Background DFP-10917, a deoxycytidine nucleoside analogue, has a unique mechanism of action resulting in leukemic cell death when administered for prolonged periods at low doses. The current phase 1/2 study investigated the safety, maximum tolerated
Autor:
Michael K. Bamat, Thomas R. King, Thomas H. Cartwright, Bassel F. El-Rayes, Reid von Borstel, Wen Wee Ma, Marwan Fakih, James Posey, Muhammad Wasif Saif
Publikováno v:
Cancer. 123:345-356
BACKGROUND Increased susceptibility to 5-fluorouracil (5-FU)/capecitabine can lead to rapidly occurring toxicity caused by impaired clearance, dihydropyrimidine dehydrogenase deficiency, and other genetic variations in the enzymes that metabolize 5-F
Autor:
Maxine de la Cruz, Joseph Arthur, Marieberta Vidal, Akhila Reddy, Sriram Yennurajalingam, Eduardo Bruera, Janet L. Williams, Carolyn Holmes, Kimmie Tallie, Supakarn Tayjasanant, Eden Mae Rodriguez, Ali Haider, Angelique Wong, Rony Dev, Jimin Wu, Suresh K. Reddy, Jessica Waletich, Diane Liu, Yvonne Heung
Publikováno v:
Cancer. 122:149-156
BACKGROUND Transdermal fentanyl (TDF) is 1 of the most common opioids prescribed to patients with cancer. However, the accurate opioid rotation ratio (ORR) from other opioids to TDF is unknown, and various currently used methods result in wide variat
Autor:
Stephen T. Sonis, Fiona Cilli, Kenneth S. Hu, Barbara A. Murphy, Michael T. Brennan, A. Dimitrios Colevas, Sewanti Limaye, Robert I. Haddad
Publikováno v:
Cancer. 119:4268-4276
BACKGROUND Oral mucositis (OM) is a significant toxicity of induction chemotherapy for locally advanced head and neck cancer (LAHNC). The safety and tolerability of AG013, an oral rinse containing recombinant Lactococcus lactis secreting mucosal prot
Autor:
Kalpna Gupta, Scott A. Jackson, Derek Vang, Chap T. Le, Dylan M. Zylla, Bruce R. Lindgren, Pankaj Gupta, Brett L. Gourley, Michael A. Kuskowski, Sonja Boatman
Publikováno v:
Cancer. 119:4103-4110
BACKGROUND Preclinical studies show that opioids stimulate angiogenesis and tumor progression through the mu opioid receptor (MOR). Although MOR is overexpressed in several human malignancies, the effect of chronic opioid requirement on cancer progre
Autor:
Manila Gaddh, Elliott F. Winton, Martha Arellano, Hanna Jean Khoury, Shannon Gleason, Leonard T. Heffner, Ana G. Antun, Morgan L. McLemore, Jacques Galipeau, Leon Bernal-Mizrachi, Fuad El Rassi, Amelia Langston
Publikováno v:
Cancer. 119:3784-3787
Background Despite prophylactic platelet transfusions, bleeding remains a significant problem in thrombocytopenic patients. Methods The antifibrinolytic agent epsilon aminocaproic acid (EACA) was administered to 44 chronically (median duration, 273 d
Autor:
Roser Velasco, Marta Campagnolo, Andreas A. Argyriou, Haralabos P. Kalofonos, Cristina Santos, Marina Cazzaniga, Sara Lonardi, Paola Alberti, Salvatore Terrazzino, Guido Cavaletti, Armando A. Genazzani, Aikaterini Angelopoulou, Jordi Bruna, Aikaterini Psaromyalou, Anna G. Antonacopoulou, Diego Cortinovis, Chiara Briani
Publikováno v:
Cancer. 119:3570-3577
BACKGROUND The current prospective, multicenter study sought to identify single nucleotide polymorphisms of voltage-gated sodium channels (SCNAs) genes that might confer susceptibility to an increased incidence and severity of oxaliplatin-induced per
Autor:
Anthony M Christensen, Deborah A. Ward, John C. Panetta, Scott C. Howard, Mary V. Relling, Jennifer L. Pauley, Alejandro R Molinelli, James M. Hoffman, Alberto S. Pappo, Clinton F. Stewart, Kristine R. Crews, Ching-Hon Pui
Publikováno v:
Cancer. 118:4321-4330
BACKGROUND: High-dose methotrexate (HDMTX)-induced acute kidney injury is a rare but life-threatening complication. The methotrexate rescue agent glucarpidase rapidly hydrolyzes methotrexate to inactive metabolites. The authors retrospectively review
Publikováno v:
Cancer. 117:5377-5382
BACKGROUND: A behavioral phenotype that characterizes nicotine dependence, the time to first cigarette after waking, is hypothesized to increase the risk of head and neck cancer. METHODS: A case-control study of histologically confirmed head and neck