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Publikováno v:
British Journal of Clinical Pharmacology. 88:1279-1287
Background: Propofol may result in hypotension, bradycardia, and loss of protective reflexes, especially in elderly patients, while esketamine, a N-methyl-D-aspartate receptor antagonists, has analgesic, anaesthetic and sympathomimetic properties and
Autor:
Dylan W. de Lange, Maaike A. Sikma, Laura Hondebrink, Claudine C. Hunault, Saskia J. Rietjens
Publikováno v:
British Journal of Clinical Pharmacology. 88:1288-1297
Context Pregabalin poisoning is mostly benign, although coma and convulsions occasionally occur. Aim To determine the dose-toxicity relationship of pregabalin. Methods Dose-toxicity data of isolated pregabalin poisonings were collected from (1) a pro
Publikováno v:
British Journal of Clinical Pharmacology. 88:1369-1372
Human leukocyte antigens (HLA) have been linked to adverse drug reactions. Generally, HLA association is phenotype specific and is related to either liver or skin injury. HLA-A*13:01 has been linked to dapsone-induced severe cutaneous drug reactions
Autor:
Kanyarat Khaeso, Oranuch Pattanacheewapull, Nontaya Nakkam, Niwat Saksit, Usanee Khunarkornsiri, Pansu Chumworathayi, Wichittra Tassaneeyakul, Parinya Konyoung, Somsak Tiamkao, Warayuwadee Amornpinyo, Teekayu P. Jorns
Publikováno v:
British Journal of Clinical Pharmacology. 88:773-786
AIMS Carbamazepine (CBZ) is one of the most common causative drugs of severe cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reactions with eosinophilia and systemic symptom
Autor:
Asad E. Patanwala, Sujita W. Narayan, Shruti Goradia, Andrew J. McLachlan, Arwa Abu Sardaneh, Jonathan Penm
Publikováno v:
British Journal of Clinical Pharmacology. 88:303-310
Aims The aim of this study was to determine the conversion dose ratio between continuous infusion metaraminol and norepinephrine in critically ill patients with shock. Methods A retrospective cohort study was conducted in adult patients with shock ad
Autor:
Yue Guan, Qun Li Song
Publikováno v:
British Journal of Clinical Pharmacology. 88:1925-1929
Acute pancreatitis refers to pancreatic enzyme activation caused by a variety of aetiologies, and mainly characterized by local inflammation of the pancreas, with or without diseases of other organ function changes. The main clinical features are abd
Autor:
Nurit Brandriss, David Stepensky, Revital Sheinberg, Natalie Dinavitser, Rimona Keidar, Matitiahu Berkovitch, Maya Berlin, Ayelet Livne, Elkana Kohn, Adina Bar-Chaim
Publikováno v:
British Journal of Clinical Pharmacology. 88:199-205
Aims In breastfeeding women, anti-epileptic therapy can lead to infant toxicities, even with newer anti-epileptic drugs such as levetiracetam. This study assessed levetiracetam breastmilk excretion and its correlation with the maternal oral dose and
Publikováno v:
British Journal of Clinical Pharmacology. 88:166-177
Aims The aims of this work were to build a semi-mechanistic tumor growth inhibition (TGI) model for metastatic colorectal cancer (mCRC) patients receiving either cetuximab+chemotherapy or chemotherapy alone and to identify early predictors of overall
Autor:
Adi Braun, Maya Berlin, Itai Gueta, Noa Markovits, Elkana Kohn, Dana Barchel, Ronen Loebstein, Matitiahu Berkovitch, Adi Gilan
Publikováno v:
British Journal of Clinical Pharmacology. 87:3910-3915
AIMS Papaverine is indicated for abdominal pain of various aetiologies. However, data on maternal and foetal safety following gestational exposure are lacking. The aim was to examine whether first trimester exposure to papaverine is associated with i
Autor:
Mei Zhang, Bo Ban, Bin Du, Xiao-Fu Cao, Xue Li, Fan Yang, Yanhong Zhang, Yuan Xu, Xi-Ting Liu, Qiu-Ping Zhang, Yue Zhou, Zhuo-Xiang Sun, Wei Zhao, Qianqian Zhao, Min Kan
Publikováno v:
British Journal of Clinical Pharmacology. 87:3599-3607
Objective Recently, letrozole has been used off-label in short pubertal boys. The experience on letrozole effectiveness and safety has been primary obtained from Caucasian children. A simple extrapolation of the data to Chinese pediatric populations