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Autor:
Hakop Gevorkyan, Laura Rosen, Fahimeh Mamashli, Polyna Khudyakov, Wei Yin, Arthur A. Simen, Derek L. Buhl, Dmitri Volfson, Ferenc Martenyi
Publikováno v:
British Journal of Clinical Pharmacology. 88:600-612
Aims TAK-071 is a muscarinic M1 receptor positive allosteric modulator designed to have low cooperativity with acetylcholine. This was a first-in-human study to evaluate the safety, pharmacokinetics, and pharmacodynamics of TAK-071. Methods TAK-071 w
Autor:
Kirsti Tiihonen, Arthur C. Ouwehand, Mika Scheinin, Marita Kailajärvi, Sanna M. Mäkelä, Sofia D. Forssten, Ville L. Langen
Publikováno v:
British Journal of Clinical Pharmacology. 87:4625-4635
AIMS Use of nonsteroidal anti-inflammatory drugs (NSAIDs) can cause damage to the gastric and duodenal mucosa. Some probiotics have proven useful in ameliorating the harmful side-effects of NSAIDs. Our aim was to evaluate whether oral administration
Autor:
Karl-Heinz Liesenfeld, John Mondick, William Knebel, Jia Kang, Rena J. Eudy-Byrne, Girish Jayadeva
Publikováno v:
British Journal of Clinical Pharmacology
Aims Adalimumab-adbm is a monoclonal antibody developed as a biosimilar to adalimumab (Humira, AbbVie Inc.). The key objectives of this study were using a population pharmacokinetic (PPK) approach to assess pharmacokinetic (PK) similarity between ada
Autor:
Anca Boldea, Stefanie Schier-Mumzhiu, Anne Bellon, Ahad Sabet, Sven D. Koch, Celine Schelcher, Maria Velinova, Roumen Nakov, Sreekanth Gattu, Daniel Dickerson, Andrej Skerjanec, Charles Tomek, Steven Schussler, Jessie Wang, Terry O'Reilly, Ly Ngo, Gordon P. Otto, Miryana Dobreva
Publikováno v:
British Journal of Clinical Pharmacology
Aims Recombinant PEGylated human granulocyte colony-stimulating factor (pegfilgrastim) is indicated for the reduction of chemotherapy-induced neutropenia and prevention of febrile neutropenia. Biosimilar pegfilgrastim is expected to reduce the financ
Publikováno v:
British journal of clinical pharmacology. 88(3)
Aims The pharmacokinetic (PK) similarity between MB02, a proposed bevacizumab biosimilar, and reference bevacizumab approved from the USA (US-bevacizumab) and European Union (EU-bevacizumab) was evaluated. Safety and immunogenicity were also assessed
Autor:
Paulo Paixão, Cristina M. Kuroda, Maiara Camotti Montanha, Caroline Ferraz Simões, Lucas Eduardo Savóia de Oliveira, Elza Kimura, Nelson Nardo Junior, Sandra Regina Bin Silva, Andréa Diniz, Josmar Mazucheli, Sérgio Seiji Yamada, Conrado de Souza Alcantara, Thiago Ferreira dos Santos Magon, Daoud Nasser
Publikováno v:
Br J Clin Pharmacol
Aims To evaluate the relative bioavailability of oral amoxicillin (AMX) tablets in comparison to AMX suspension in Roux-en-Y gastric bypass bariatric subjects. Methods A randomized, double-blind, cross-over study was performed on the bioavailability
Autor:
Athiwat Hutchaleelaha, Timothy Mant, Elizabeth Allen, Donna Oksenberg, Josh Lehrer-Graiwer, Mira Patel, Carla Washington, Daniel D. Gretler, Vincent Siu
Publikováno v:
British Journal of Clinical Pharmacology
Aims Voxelotor (previously GBT440) is a haemoglobin (Hb) modulator that increases Hb-oxygen affinity, thereby reducing Hb polymerization and sickling of red blood cells (RBCs), being developed as a once-daily oral drug to treat sickle cell disease (S
Autor:
Reinhard Schinzel, S Friedrich, Agnes Bosch, Nicole Winzer, Christian Ott, Roland E. Schmieder, Frank Tegtmeier
Publikováno v:
Br J Clin Pharmacol
AIMS: Reduced nitric oxide (NO) availability may adversely affect renal perfusion and glomerular filtration. The aim of the present study was to characterize in detail the pharmacological effects of VAS203, an inhibitor of NO synthase, on renal haemo
Autor:
Valentina Mongelli, Annalisa Piccinno, Massimo Corradi, Frans van den Berg, Dave Singh, Brian Leaker, Brian J. Lipworth, Sara Collarini, Sunny Jabbal, Sonia Biondaro, Luigi Santoro
Publikováno v:
British Journal of Clinical Pharmacology
Singh, D, van den Berg, F, Leaker, B, Corradi, M, Jabbal, S, Collarini, S, Mongelli, V, Santoro, L, Piccinno, A, Biondaro, S & Lipworth, B 2019, ' Comparison of the effect of beclometasone/formoterol in asthma patients after methacholine-induced bronchoconstriction : A noninferiority study using metered dose vs. dry powder inhaler ', British Journal of Clinical Pharmacology . https://doi.org/10.1111/bcp.13847
Singh, D, van den Berg, F, Leaker, B, Corradi, M, Jabbal, S, Collarini, S, Mongelli, V, Santoro, L, Piccinno, A, Biondaro, S & Lipworth, B 2019, ' Comparison of the effect of beclometasone/formoterol in asthma patients after methacholine-induced bronchoconstriction : A noninferiority study using metered dose vs. dry powder inhaler ', British Journal of Clinical Pharmacology . https://doi.org/10.1111/bcp.13847
Aims: To demonstrate the noninferiority of extrafine beclomethasone/formoterol fumarate (BDP/FF) dry powder inhaler (DPI) vs. extrafine BDP/FF pressurized metered dose inhaler (pMDI; Foster® 100/6 μg NEXThaler and pMDI, respectively) in the onset o
Publikováno v:
British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology, 85(2), 442-453. Wiley
British Journal of Clinical Pharmacology, 85(2), 442-453. Wiley
AIMS: The present study assessed the acute effects of methadone and buprenorphine on actual on-road driving performance and neurocognitive function.METHODS: Methadone (5 and 10 mg per oral) and buprenorphine (0.2 and 0.4 mg sublingual) were administe