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Autor:
Karolina Akinosoglou, Nikolaos Tsokos, Georgios‐Stefanos Soumelas, Thomas Tsaganos, Ioulia K. Tseti, Evangelos J. Giamarellos-Bourboulis, Nikolaos Tziolos, Athina Pyrpasopoulou, Styliani Sympardi, Marina Koupetori, Asterios Karagiannis, Charalambos Gogos
Publikováno v:
British Journal of Clinical Pharmacology
Aim No randomized study has been conducted to investigate the use of intravenous paracetamol (acetaminophen, APAP) for the management of fever due to infection. The present study evaluated a new ready-made infusion of paracetamol. Methods Eighty pati
Autor:
Golnaz Vaseghi, Ismail Laher, Hajar Naji Esfahani, Ahmad Ghasemi, Alireza Abed, Laleh Shariati, Shaghayegh Haghjooy Javanmard, Alireza Amouheidari
Publikováno v:
Br J Clin Pharmacol
Aims Breast cancer is the most frequently occurring cancer in women. Lumpectomy followed by radiotherapy is suggested to be as effective as a total mastectomy. Radiation-induced dermatitis often occurs as a result of breast radiotherapy. Recent studi
Autor:
Jin Tack Kim, Joon Sung Lee, Jaewon Oh, Jin Han Kang, Keun Young Lee, Dae-Chul Jeong, Jong-Seo Yoon, Young Yull Koh, Hyun Seung Lee
Publikováno v:
British Journal of Clinical Pharmacology. 66:854-860
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The analgesic and anti-inflammatory efficacy of dexibuprofen compared with ibuprofen in adults with osteoarthritis, rheumatoid arthritis and dental pain. WHAT THIS STUDY ADDS • Dexibuprofen is as effecti
Publikováno v:
British Journal of Clinical Pharmacology. 62:538-545
Aim To assess residual psychomotor and cognitive effects of a modified-release formulation of zolpidem (zolpidem-MR), developed to provide sustained hypnotic efficacy during the whole night, compared with placebo and flurazepam. Methods Twenty-four h
Autor:
Todd DeVries, Arline Nakanishi, Andrea Wang, Ralph Zitnik, Christopher Banfield, Ivan Nestorov
Publikováno v:
British Journal of Clinical Pharmacology. 62:435-445
Aims To present the results of the pharmacokinetic analysis of the concentration–time profiles of etanercept, a soluble receptor tumour necrosis factor (TNF) antagonist, in more than 1300 subjects with psoriasis. Methods Pharmacokinetic samples wer
Publikováno v:
British Journal of Clinical Pharmacology. 60:24-31
Aims To compare the onset and duration of action of the new antihistamine levocetirizine with that of the second-generation antihistamine fexofenadine using the Vienna Challenge Chamber (VCC). The latter is an environment where subjects can be expose
Autor:
Robert Conti, Stéphane Mouly, Saïd El Meski, Guy Simoneau, Alain Gaudric, Yves Tillet, Irène Jarrin, Isabelle Mahé, Jacqueline Otéro, Jean-François Bergmann, Catherine Tavera
Publikováno v:
British Journal of Clinical Pharmacology. 59:220-226
Background Cataract surgery requires prolonged anaesthesia, concomitant with permanent hydration and lubrication of the cornea, in order to provide a clear view of the operation area. Aims The primary objective of the study was to assess several form
Autor:
Hans Lennernäs, M Holmberg, Bo Lennernäs, Christer Nyström, Thomas Hedner, Susanne Bredenberg
Publikováno v:
British Journal of Clinical Pharmacology. 59:249-253
It is estimated that two-thirds of cancer patients will at some point during their illness experience breakthrough pain. In this study, the pharmacokinetics of a novel sublingual dosage form of fentanyl developed for breakthrough pain was evaluated.E
Autor:
Alain Li Wan Po
Publikováno v:
British Journal of Clinical Pharmacology. 63:268-270
An important question to ask about any drug is whether increasing the dose improves the effect. When licensing a new drug, regulatory authorities require manufacturers to provide data to support proposed dosage regimens. However, premarketing studies
Publikováno v:
British Journal of Clinical Pharmacology. 42:307-311
1. Shivering is frequent during the post-anaesthetic recovery period, and there is no clear consensus about the best strategy for its treatment. We tested the efficacy of two commonly used analgesic drugs, pethidine and metamizol. 2. A randomized, do