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Publikováno v:
Brain Research. 1719:30-39
Schizophrenia is known to be a complex and disabling psychiatric disorder. Dopamine receptor antagonists have a significant therapeutic effect in improving the positive symptoms that are associated with the illness. Therefore, dopamine receptor antag
Autor:
Marta Tkacz, Joanna Listos, Patrycja Kupnicka, Sylwia Talarek, Dariusz Chlubek, Irena Baranowska-Bosiacka, Katarzyna Barczak, Maciej Tarnowski, Izabela Gutowska, Emilia Metryka
Publikováno v:
Brain Research. 1719:49-56
Morphine is one of the most potent analgesics used in medicine and it's long-term use is associated with the risk of the state of dependence. The cessation of chronic morphine administration leads to withdrawal signs which are associated with neurotr
Autor:
Paola Lenzi, Rosangela Ferese, Francesca Biagioni, Michele Madonna, Fiona Limanaqi, Francesco Fornai, Stefano Gambardella
Publikováno v:
Brain Research. 1719:157-175
Methamphetamine (Meth) produces a variety of epigenetic effects in the brain, which are seminal to establish long-lasting alterations in neuronal activity. However, most epigenetic changes were described by measuring the rough amount of either histon
Publikováno v:
Brain Research. 1718:137-147
It is known that angiotensin II (AII) is sensed by subfornical organ (SFO) to induce drinking behaviors and autonomic changes. AII at picomolar concentrations have been shown to induce Ca2+ oscillations and increase in the amplitude and frequency of
Publikováno v:
Brain Research. 1718:46-52
Objective The activation of renin angiotensin system is involved in multiple pathological processes. Growing evidence reveal that Angiotensin II (Ang II) contributes to the pathogenesis of Alzheimer disease (AD). However, the underlying mechanisms ar
Autor:
Zhiguo He, Patrick Mismetti, Xavier Delavenne, Clémentine Puech, Nathalie Perek, Valérie Forest
Publikováno v:
Brain Research
Brain Research, Elsevier, 2019, 1719, pp.57-63. ⟨10.1016/j.brainres.2019.05.024⟩
Brain Research, 2019, 1719, pp.57-63. ⟨10.1016/j.brainres.2019.05.024⟩
Brain Research, Elsevier, 2019, 1719, pp.57-63. ⟨10.1016/j.brainres.2019.05.024⟩
Brain Research, 2019, 1719, pp.57-63. ⟨10.1016/j.brainres.2019.05.024⟩
Anticoagulant therapy presents iatrogenic effects such as intracerebral hemorrhage (ICH). The latest anticoagulants on the market, direct oral anticoagulants (DOACs) such as apixaban, dabigatran and rivaroxaban, are reported to cause less ICH than ot
Publikováno v:
Brain Research. 1719:176-182
The ventral tegmental area (VTA) is a key brain region, involved in the dependency on nicotine. Studies have shown that orexin and cannabinoids are likely to play an important role in nicotine dependency. In this study, the effect of orexin receptor-
Autor:
Maria Rosaria Melis, Fabrizio Sanna, Cristina Cocco, Laura Angioni, Maria Pina Sorighe, Antonio Argiolas, Jessica Bratzu
Publikováno v:
Brain research. 1773
Saporin conjugated to oxytocin (OXY-SAP) destroys neurons expressing oxytocinergic receptors. When injected unilaterally in the substantia nigra of male rats, OXY-SAP causes a dose-dependent decrease up to 55 % in nigral Tyrosine Hydroxylase (TH)-imm
Autor:
Kevin Chen, Wen-Ming Hsu, Abigail T. Shih, Frank Hong, Jean C. Shih, Boris Tabakoff, Yi-Bu Chen, Tamara Palagashvili
Publikováno v:
Brain Res
Monoamine oxidase B (MAO B) oxidizes trace amine phenylethylamine (PEA), and neurotransmitters serotonin and dopamine in the brain. We reported previously that PEA levels increased significantly in all brain regions, but serotonin and dopamine levels
Publikováno v:
Brain research. 1771
Anti-epileptic drugs (AEDs) are the mainstay of epilepsy treatment but these may be a potential risk factor for behavioral disturbances particularly depression which requires treatment. In this study, the effect of antidepressant sertraline (SRT) in