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Publikováno v:
Brain Research. 1624:78-85
3-O-demethylswertipunicoside (3-ODS) has been reported to protect dopaminergic neurons against neurotoxicity induced by 1-methyl-4-phenylpyridinium (MPP(+)) in PC12 cells. Here, we investigate the neuroprotective effects in vivo and antioxidant activ
Autor:
Andrew M. J. Young, Ishan Gupta
Publikováno v:
Brain research. 1687
The non-competitive glutamate antagonist, phencyclidine is used in rodents to model behavioural deficits see in schizophrenia. Importantly, these deficits endure long after the cessation of short-term chronic treatment (sub-chronic), indicating that
Publikováno v:
Brain Research. 1608:40-50
Recent studies have shown that Onecut (Oc) transcription factors may be involved in the early development of midbrain dopaminergic neurons (mdDA). The expression profile of Oc factors matches that of Lmx1a, an important intrinsic transcription factor
Publikováno v:
Brain Research. 1554:12-20
Extracellular acidosis is a common feature in pain-generating pathological conditions. Acid-sensing ion channels (ASICs), pH sensors, are distributed in peripheral sensory neurons and participate in nociception. Morphine exerts potent analgesic effec
Publikováno v:
Brain Research. 1553:24-30
General anesthetics are hypothesized to cause unconsciousness by interrupting communication pathways within the cerebral cortex. A correlate of this has been demonstrated in mouse neocortical slices, where anesthetics disrupt the spread of population
Autor:
V. Visockis, Anne King
Publikováno v:
Brain Research. 1513:9-16
There is strong evidence that M-currents modulate peripheral sensory afferent excitability and that altered M-current efficacy may underpin aspects of pain-induced nociceptor sensitization. Less clear is the role of the M-current in regulating centra
Publikováno v:
Brain Research. 1483:89-95
Peroxisome proliferator-activated receptor delta (PPARδ) is ubiquitously expressed in the vasculature, including cerebral circulation. The role of PPARδ in metabolism of tetrahydrobiopterin (BH4) has not been studied in the cerebral microvasculatur
Publikováno v:
Brain Research. 1426:18-29
Applying emetine, a protein synthesis inhibitor, at 20–40 μM for 90–120 min prior to LTP induction in hippocampal slices from young rats (2–3 weeks) and washing it out afterwards revealed a slowly developing potentiation that reached maximum a
Autor:
Christian Pifl, Michael Freidl, Michael L. Berger, Franz Gabor, Johannes Winkler, Winfried Neuhaus, Phillip Szkokan, Christian R. Noe, Michael Wirth
Publikováno v:
Brain Research. 1394:49-61
Changes of the functionality of the blood-brain barrier (BBB) have been reported in the context of several brain related diseases such as multiple sclerosis, epilepsy, Alzheimer's disease and stroke. Several publications indicated the presence and fu
Publikováno v:
Brain Research. 1349:48-55
Studies have demonstrated defects of DA and 5HT neurotransmission in dietary fat induced obese animals. In the present study, we used a perfusion system to assay the release of DA and 5HT from striatal slices preloaded with [(3)H]-DA or [(3)H]-5HT. T