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of 426
pro vyhledávání: ''
Autor:
Josef Vormoor, Gareth J. Veal, Tobias Menne, Daniel Slade, Joshua Savage, Geoff Shenton, Pamela Kearns, Britta Vormoor, Sarah J. Johnson, Julie Irving, Ruth Plummer, Lucinda Billingham
Publikováno v:
BMJ Open. 12:e059872
IntroductionEvent free survival rates at 15 years for paediatric patients with relapsed/refractory acute lymphoblastic leukaemia (ALL) are 30-50%, with 5-year survival for adult patients only 20%. A large proportion of patients with newly diagnosed a
Autor:
Bertrand Drugeon, Olivier Mimoz, Karim Asehnoune, Antoine Roquilly, Sigismond Lasocki, Olivier Desebbe, Pierre Bouzat, Bruno Vielle, Thibault Loupec, Elsa Parot-Schinkel, Marc Danguy des Déserts, Maria Lahlou-Casulli, Vincent Collange, Alexis Duchalais, Delphine Garrigue, Benjamin Mounet, Franck Hamard, Jean-Stéphane David, Maxime Leger, Emmanuel Rineau, Guillaume Bouhours, Adeline Lebail, Emmanuel Samson, Xavier Capdevilla, Fabien Swisser, Marc Danguy Des Deserts, Sébastien Parent, Gaetan Gavazzi, Benjamin Bijok
Publikováno v:
BMJ Open
BMJ Open, Vol 11, Iss 1 (2021)
BMJ Open, Vol 11, Iss 1 (2021)
IntroductionBlood transfusion and anaemia are frequent and are associated with poor outcomes in patients with hip fracture (HF). We hypothesised that preoperative intravenous iron and tranexamic acid (TXA) may reduce the transfusion rate in these pat
Publikováno v:
BMJ Open, Vol 11, Iss 12 (2021)
BMJ Open
BMJ Open
ObjectiveTo assess the efficacy and safety of bevacizumab (BEV) in patients with glioma.DesignSystematic review and meta-analysis.ParticipantsAdults aged 18 years and above, whose histology was confirmed to be malignant glioma.Primary and secondary o
Publikováno v:
BMJ Open
BMJ Open, Vol 11, Iss 11 (2021)
BMJ Open, Vol 11, Iss 11 (2021)
IntroductionAbnormal coagulation function aggravates the prognosis of patients with traumatic brain injury (TBI). It was reported that the antifibrinolytic drug tranexamic acid (TXA) could reduce intracranial haemorrhage and mortality in non-operativ
Autor:
Adam M. Leventhal, Steven Sussman, Lourdes Baezconde-Garbanati, Leah Meza, Jennifer B. Unger, Artur Galimov, Jimi Huh
Publikováno v:
BMJ Open, Vol 11, Iss 10 (2021)
BMJ open, vol 11, iss 10
BMJ Open
BMJ open, vol 11, iss 10
BMJ Open
ObjectivesIn February 2020, the US Food and Drug Administration issued a guidance restricting the sales and distribution of cartridge-based e-cigarettes with flavours other than tobacco and menthol. Disposable devices were exempt from this guidance.
Autor:
Manisha Nair, Shakuntala Chhabra, Saswati Sanyal Choudhury, Dipika Deka, Gitanjali Deka, Swapna D Kakoty, Pramod Kumar, Pranabika Mahanta, Robin Medhi, Anjali Rani, Seeresha Rao, Indrani Roy, Carolin Solomi V, Ratna Kanta Talukdar, Farzana Zahir, Nimmi Kansal, Anil Arora, Charles Opondo, Jane Armitage, Michael Laffan, Simon Stanworth, Maria Quigley, Colin Baigent, Marian Knight, Jennifer J Kurinczuk
Publikováno v:
BMJ Open, Vol 11, Iss 10 (2021)
BMJ Open
BMJ Open
ObjectivesTo investigate the association between coagulation parameters and severity of anaemia (moderate anaemia: haemoglobin (Hb) 7–9.9 g/dL and severe anaemia: Hb DesignA prospective cohort study of pregnant women recruited in the third trimeste
Autor:
Zhengdong Fang, Guangwei Yang, Zhenjie Liu, Wan Zhang, Li Yin, Zhenyu Shi, Linjun Wang, Jianing Yue, Libin Zhang, Yuefeng Zhu, Bin Gao, Miaomiao Li, Lubin Li, Xueying Ke, Zheng Gu, Wei Han
Publikováno v:
BMJ Open, Vol 11, Iss 10 (2021)
BMJ Open
BMJ Open
IntroductionInferior vena cava (IVC) filters are commonly used in patients with venous thromboembolism to prevent fatal pulmonary embolism, but the thrombosis risk increases after filter placement. Warfarin is a widely anticoagulant, but long-term mo
Autor:
Jianguo Li, Yongyu Mei, Lina Wu, Xuejun Li, Liang Peng, Zhihua Liu, Luping Lin, Jing Yuan, Shu Zhu
Publikováno v:
BMJ Open, Vol 11, Iss 10 (2021)
BMJ Open
BMJ Open
IntroductionCombination antiviral therapy of nucleos(t)ide analogue (NA) and pegylated interferon alpha (peg-IFN alpha) decrease hepatitis B virus (HBV) surface antigen (HBsAg) levels to achieve functional cure and improve long-term prognosis in chro
Autor:
Jennie Hsiu Mien Yang, Ashish Marwaha, Wai-Yee Cheung, Hayley A Hutchings, Kymberley Carter, Rachel Stenson, Colin M. Dayan, Gareth Dunseath, Jane Bowen-Morris, Danijela Tatovic, Mohammad Alhadj Ali, Greg Fegan, Stephen D. Luzio, Amy Brown, Stephen Hiles, Gail Holland, Susie Marques-Jones, Timothy Tree, Nadim Bashir, John Gregory
Publikováno v:
BMJ Open
BMJ Open, Vol 11, Iss 10 (2021)
BMJ Open, Vol 11, Iss 10 (2021)
IntroductionMost individuals newly diagnosed with type 1 diabetes (T1D) have 10%–20% of beta-cell function remaining at the time of diagnosis. Preservation of residual beta-cell function at diagnosis may improve glycaemic control and reduce longer-
Autor:
Dongsheng Chen, Yi Gong, Lichao Hou, Ran Zhang, Xiao-Zhi Wu, Fei Yang, Yongyong Yang, Min Li, Haiyan Xue, Guo-Zhong Chen, Huanghui Wu, Ruizhe Liao
Publikováno v:
BMJ Open, Vol 11, Iss 10 (2021)
BMJ Open
BMJ Open
IntroductionPatients with obstructive sleep apnoea (OSA) are more sensitive to postanaesthesia respiratory depression. Whether different anaesthetic regimens (intravenous-based or inhalational-based general anaesthesia) affect the postanaesthesia res