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Autor:
Jennie Hsiu Mien Yang, Ashish Marwaha, Wai-Yee Cheung, Hayley A Hutchings, Kymberley Carter, Rachel Stenson, Colin M. Dayan, Gareth Dunseath, Jane Bowen-Morris, Danijela Tatovic, Mohammad Alhadj Ali, Greg Fegan, Stephen D. Luzio, Amy Brown, Stephen Hiles, Gail Holland, Susie Marques-Jones, Timothy Tree, Nadim Bashir, John Gregory
Publikováno v:
BMJ Open
BMJ Open, Vol 11, Iss 10 (2021)
BMJ Open, Vol 11, Iss 10 (2021)
IntroductionMost individuals newly diagnosed with type 1 diabetes (T1D) have 10%–20% of beta-cell function remaining at the time of diagnosis. Preservation of residual beta-cell function at diagnosis may improve glycaemic control and reduce longer-
Publikováno v:
BMJ Open, Vol 11, Iss 8 (2021)
BMJ Open
BMJ Open
ObjectivesThe aims of this study were to describe the following: (1) the time to change of therapy in patients with type 2 diabetes who had initiated metformin monotherapy as first-line treatment and (2) the sequence in which subsequent therapeutic r
Publikováno v:
BMJ Open, Vol 10, Iss 10 (2020)
IntroductionInfants born late preterm (34+0 to 36+6 weeks’ gestational age) have frequent episodes of intermittent hypoxaemia compared with term infants. Caffeine citrate reduces apnoea and intermittent hypoxaemia and improves long-term neurodevelo
Autor:
Amadou Tapily, Djibrilla Issiaka, Serge Yerbanga, Opokua Ofori-Anyinam, Frederic Sompougdou, Paul Milligan, Alassane Dicko, Daniel Chandramohan, Almahamoudou Mahamar, Modibo Diarra, Ismaila Thera, Halidou Tinto, Matthew Cairns, Irene Kuepfer, Koualy Sanogo, Jean-Bosco Ouédraogo, Brian Greenwood, Issaka Sagara, Issaka Zongo
Publikováno v:
BMJ Open, Vol 10, Iss 9 (2020)
BMJ Open
BMJ Open
IntroductionSeasonal malaria chemoprevention (SMC), with sulphadoxine–pyrimethamine plus amodiaquine (SP+AQ) is effective but does not provide complete protection against clinical malaria. The RTS,S/AS01Emalaria vaccine provides a high level of pro
Autor:
Silvia Josefina Venero-Fernández, Ramón Suárez-Medina, Andrew W. Fogarty, Zunilda Verdecia-Pérez, John Britton, Carmona Cristina, Maria Betancourt-López, Barbara Corona-Tamayo, Maria Loinaz-Gonzalez, Nieves Sardinas-Baez, Vilma Alvarez-Valdés
Publikováno v:
BMJ Open
ObjectivesAsthma has not been extensively studied in low-income and middle-income countries, where risk factors and access to treatment may differ from more affluent countries. We aimed to identify the prevalence of asthma and local risk factors in H
Autor:
Siew M. Fong, Heidi C. Smith-Vaughan, Anna Marie Nathan, Catherine A. Byrnes, Robert S. Ware, Anne B. Chang, Peter S. Morris, Jessie de Bruyne, Gabrielle B. McCallum, Noorazlina Saari, Tsin W. Yeo, Bilawara Lee, Nachal Nachiappan, Paul J. Torzillo, Keith Grimwood, Mong How Ooi, John W. Upham
Publikováno v:
BMJ Open
IntroductionEarly childhood pneumonia is a common problem globally with long-term complications that include bronchiectasis and chronic obstructive pulmonary disease. It is biologically plausible that these long-term effects may be minimised in young
Publikováno v:
BMJ Open
Objectives Whether warfarin-treated patients with non-valvular atrial fibrillation (NVAF) who exhibit good control will experience deterioration in control over time is uncertain. We designed this study to examine the time in therapeutic range (TTR)
Autor:
Charles Shey Wiysonge, Marie Kobela, Marcellin Nimpa Mengouo, Frangy Baonga, Valantine Ngum Ndze
Publikováno v:
BMJ Open
Objective The aim of this study was to estimate the proportion of rubella disease in a measles case-based surveillance in Cameroon prior to rubella vaccine introduction into the national immunisation programme. Design This was a cross-sectional study
Autor:
Marianne Aadal, Eirik Skogvoll, Andreas Austgulen Westin, Olav Spigset, Malin Brekke, Espen Molden
Publikováno v:
BMJ Open
Objectives Pregnancy may cause changes in drug disposition, dose requirements and clinical response. For lithium, changes in disposition during pregnancy have so far been explored in a single-dose study on 4 participants only. The aim of this study w
Autor:
Olawale Salami, Ariadna Nebot Giralt, Janice Lee, Marc Lallemant, Isaac K. Nyamongo, Onyango Ouma, Christiana Nöstlinger, Bruno Marchal
Publikováno v:
BMJ Open
Background Improving access to paediatric HIV treatment requires both large-scale treatment programmes and medication that is adapted to infants and children9s needs. The WHO recommends lopinavir/ritonavir as first-line antiretroviral therapy for all