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pro vyhledávání: ''
Autor:
Minna Ampuja, Anne Kallioniemi, Alejandra Rodriguez-Martinez, Maaria Palmroth, Tommi Rantapero, Emma-Leena Alarmo, Matti Nykter
Publikováno v:
BMC Genomics
Background Bone morphogenetic protein 4 (BMP4) plays an important role in cancer pathogenesis. In breast cancer, it reduces proliferation and increases migration in a cell line-dependent manner. To characterize the transcriptional mediators of these
Autor:
Cindy Körner, Heike Wilhelm, Janine Jung, Angelika Wörner, Ewald Münstermann, Stefan Wiemann, Nese Erdem, Omar Salem
Publikováno v:
BMC Genomics
Background miRNAs are small noncoding RNA molecules that play an important role in post-transcriptional regulation of gene expression. Length and/or sequence variants of the same miRNA are termed isomiRs. While most isomiRs are functionally redundant
Autor:
Lotfi Chouchane, Erchin Serpedin, Chifeng Ma, Yi Chen, Yufei Huang, Yusheng Feng, Salah Gehani, Mario Flore, Issam Al-Bozom, Konduru S Sastry
Publikováno v:
BMC Genomics
Background We considered the prediction of cancer classes (e.g. subtypes) using patient gene expression profiles that contain both systematic and condition-specific biases when compared with the training reference dataset. The conventional normalizat
Autor:
Jayavelu, Naresh Doni, Bar, Nadav
Publikováno v:
BMC Genomics
Background MicroRNAs (miRNAs) are small non-coding RNAs that regulate genes at the post-transcriptional level in spatiotemporal manner. Several miRNAs are identified as prognostic and diagnostic markers in many human cancers. Estimation of the tempor
Autor:
Huanming Yang, Ramneek Gupta, José M.A. Moreira, Nils Brünner, Mathilde Borg Houlberg Thomsen, Yong Hou, Lars Bolund, Xiuqing Zhang, Henrik J. Ditzel, Anne-Sofie Schrohl, Rikke Linnemann Nielsen, Xun Xu, Jun Wang, Dongbing Liu, Stine Ninel Hansen, Jan Stenvang, Natasja Ehlers, Shida Zhu, Guangbiao Wang
Publikováno v:
BMC Genomics
Hansen, S N, Ehlers, N S, Zhu, S, Thomsen, M B H, Nielsen, R L, Liu, D, Wang, G, Hou, Y, Zhang, X, Xu, X, Bolund, L, Yang, H, Wang, J, Moreira, J, Ditzel, H J, Brünner, N, Schrohl, A-S, Stenvang, J & Gupta, R 2016, ' The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells ', BMC Genomics, vol. 17, 442 . https://doi.org/10.1186/s12864-016-2749-4
Hansen, S N, Ehlers, N S, Zhu, S, Thomsen, M B H, Nielsen, R L, Liu, D, Wang, G, Hou, Y, Zhang, X, Xu, X, Bolund, L, Yang, H, Wang, J, Moreira, J, Ditzel, H J, Brünner, N, Rasmussen, A-S S, Stenvang, J & Gupta, R 2016, ' The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells ', B M C Genomics, vol. 17, 442 . https://doi.org/10.1186/s12864-016-2749-4
Hansen, S N, Ehlers, N S, Zhu, S, Thomsen, M B H, Nielsen, R L, Liu, D, Wang, G, Hou, Y, Zhang, X, Xu, X, Bolund, L, Yang, H, Wang, J, Moreira, J, Ditzel, H J, Brünner, N, Schrohl, A-S, Stenvang, J & Gupta, R 2016, ' The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells ', B M C Genomics, vol. 17, no. 1, pp. 442 . https://doi.org/10.1186/s12864-016-2749-4
Hansen, S N, Ehlers, N S, Zhu, S, Thomsen, M B H, Nielsen, R L, Liu, D, Wang, G, Hou, Y, Zhang, X, Xu, X, Bolund, L, Yang, H, Wang, J, Moreira, J, Ditzel, H J, Brünner, N, Schrohl, A-S, Stenvang, J & Gupta, R 2016, ' The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells ', BMC Genomics, vol. 17, 442 . https://doi.org/10.1186/s12864-016-2749-4
Hansen, S N, Ehlers, N S, Zhu, S, Thomsen, M B H, Nielsen, R L, Liu, D, Wang, G, Hou, Y, Zhang, X, Xu, X, Bolund, L, Yang, H, Wang, J, Moreira, J, Ditzel, H J, Brünner, N, Rasmussen, A-S S, Stenvang, J & Gupta, R 2016, ' The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells ', B M C Genomics, vol. 17, 442 . https://doi.org/10.1186/s12864-016-2749-4
Hansen, S N, Ehlers, N S, Zhu, S, Thomsen, M B H, Nielsen, R L, Liu, D, Wang, G, Hou, Y, Zhang, X, Xu, X, Bolund, L, Yang, H, Wang, J, Moreira, J, Ditzel, H J, Brünner, N, Schrohl, A-S, Stenvang, J & Gupta, R 2016, ' The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells ', B M C Genomics, vol. 17, no. 1, pp. 442 . https://doi.org/10.1186/s12864-016-2749-4
Background: Resistance to taxane-based therapy in breast cancer patients is a major clinical problem that may be addressed through insight of the genomic alterations leading to taxane resistance in breast cancer cells. In the current study we used wh
Publikováno v:
BMC Genomics
Background We had previously identified Ctr9, the key scaffold subunit of the human RNA polymerase II (RNAPII) associated factor complex (PAFc), as a key factor regulating a massive ERα target gene expression and ERα-positive breast cancer growth.
Autor:
Jhih Rong Lin, Zhengdong D. Zhang, Ying Cai, Cristina Montagna, Kelly O'Brien, Quanwei Zhang, Rubén Nogales-Cadenas, Wen Zhang
Publikováno v:
BMC Genomics
Background Malignant breast cancer with complex molecular mechanisms of progression and metastasis remains a leading cause of death in women. To improve diagnosis and drug development, it is critical to identify panels of genes and molecular pathways
Autor:
John R. Mackey, Preethi Krishnan, Sambasivarao Damaraju, Kathryn Graham, Ashok Narasimhan, Olga Kovalchuk, Bo Wang, Dongping Li, Richard Berendt, Sunita Ghosh
Publikováno v:
BMC Genomics
Background Prognostication of Breast Cancer (BC) relies largely on traditional clinical factors and biomarkers such as hormone or growth factor receptors. Due to their suboptimal specificities, it is challenging to accurately identify the subset of p
Autor:
Andrew Tutt, Cheryl Gillett, Brian Burford, David Dornan, Anita Grigoriadis, Pierfrancesco Marra, Sarah E Pinder, Patrycja Gazinska, Lars Holmberg, Grazyna Fedorowicz, Anca Mera, Emanuele de Rinaldis, Zora Modrusan
Publikováno v:
BMC Genomics
BACKGROUND: This study focuses on the analysis of miRNAs expression data in a cohort of 181 well characterised breast cancer samples composed primarily of triple-negative (ER/PR/HER2-negative) tumours with associated genome-wide DNA and mRNA data, ex
Autor:
Francesca M. Buffa, David R. Mole, Ashwag Albukhari, Carme Camps, Syed Haider, Spyros Oikonomopoulos, Ioannis Ragousis, Peter J. Ratcliffe, Johannes Schödel, Hani Choudhry, Adrian L. Harris, Daniela Moralli
Publikováno v:
BMC Genomics
Transcriptional responses to hypoxia are central to the pathogenesis of many types of cancer. Today, pan-genome analyses of hypoxia have focused on protein-coding genes, however, the role of non-coding RNAs, in particular long non-coding RNAs (lncRNA