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Publikováno v:
BMC Clinical Pathology
Background Knowledge is limited regarding the association between stem cells in histologically benign breast tissue and risk factors for breast cancer, and hence we addressed this issue in the present study. Recently, we assessed the histology of ben
Autor:
Helen Gogas, Vassiliki Kotoula, Flora Stavridi, Christos Papadimitriou, George Pentheroudakis, Anastasia G Eleftheraki, George Fountzilas, Ioannis Kostopoulos, Triantafyllia Koletsa, Angelos Koutras, Anna Batistatou, Mattheos Bobos, Irene Konstantopoulou, Dimitrios Pectasides, Ioannis Efstratiou, Dimosthenis Skarlos
Publikováno v:
BMC Clinical Pathology
Background alphaB-crystallin is a small heat shock protein that has recently been characterized as an oncoprotein correlating with the basal core phenotype and with negative prognostic factors in breast carcinomas. The purpose of this study was to ev
Autor:
Carina Strand, Markus Ringnér, Mårten Fernö, Göran Jönsson, Ingrid Hedenfalk, Sara Brommesson, Per-Uno Malmström, Dorthe Grabau
Publikováno v:
BMC Clinical Pathology, Vol 8, Iss 1, p 6 (2008)
BMC Clinical Pathology
BMC Clinical Pathology
Background Today, no objective criteria exist to differentiate between individual primary tumors and intra- or intermammary dissemination respectively, in patients diagnosed with two or more synchronous breast cancers. To elucidate whether these tumo
Publikováno v:
BMC Clinical Pathology
BMC Clinical Pathology, Vol 12, Iss 1, p 3 (2012)
BMC Clinical Pathology, Vol 12, Iss 1, p 3 (2012)
Background Chromogenic in situ hybridization (CISH) is fast becoming a well established technique for easy and sensitive determination of HER2 gene status in breast cancer. However, for the chromogenic method to achieve status as a safe and reliable
Autor:
Peter H. Watson, A. J. Dawson, Norman M. Pettigrew, Andreea Nistor, Yvonne Myal, Karim Tabiti
Publikováno v:
BMC Clinical Pathology, Vol 6, Iss 1, p 2 (2006)
BMC Clinical Pathology
BMC Clinical Pathology
Background The clinical benefit of determining the status of HER-2/neu amplification in breast cancer patients is well accepted. Although immunohistochemistry (IHC) is the most frequently used method to assess the over-expression of HER-2 protein, fl
Autor:
Johan Lundin, Liisa Sailas, Tiina Lehtimäki, Mikael Lundin, Vesa Kataja, Kaija Holli, Heikki Joensuu, Juho Konsti, Jorma Isola, Taina Turpeenniemi-Hujanen, Harri Sihto
Publikováno v:
BMC Clinical Pathology
BMC Clinical Pathology, Vol 11, Iss 1, p 3 (2011)
BMC Clinical Pathology, Vol 11, Iss 1, p 3 (2011)
Background The aim of the study was to develop a virtual microscopy enabled method for assessment of Ki-67 expression and to study the prognostic value of the automated analysis in a comprehensive series of patients with breast cancer. Methods Using
Autor:
Brian Z. Ring, Rodney A. Beck, Douglas T. Ross, David G. Hicks, Robert S. Seitz, Shuyuan Yeh, Xi Wang, Kirsten Woolf
Publikováno v:
BMC Clinical Pathology
Background The role of vitamin E in breast cancer prevention and treatment has been widely investigated, and the different tocopherols that comprise this nutrient have been shown to have divergent associations with cancer outcome. Our previous studie