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pro vyhledávání: '"398"'
Autor:
Robin Joyce, Rebecca Karp, David Avigan, Ayad Hamdan, Erik J. Uhlmann, Jon E. Arnason, Myrna Nahas, Jacalyn Rosenblatt
Publikováno v:
Blood. 126:5453-5453
Introduction Pure red cell aplasia (PRCA) is a severe consequence of major and bi-directional ABO-mismatched allogeneic stem cell transplantation (allo-SCT), likely the result of persistent isoagglutinin-producing host plasma cells that have escaped
Autor:
Juan M. Peralta, Diane M. Warren, Stephen T. Warren, Tom E. Howard, Sandra G. Porter, John Blangero, Juan Carlos Souto, Todd M. Smith, Alfonso Buil, Karl Fernstrom, Jordi Fontcuberta, Manana Khachidze, Kevin R. Viel, Deepa K. Machiah, Laura Almasy, José Manuel Soria, W. Dana Flanders
Publikováno v:
Blood. 109:3713-3724
Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quantitative trait that is strongly correlated with thrombosis risk. Polymorphisms within only 1 gene, the ABO blood-group locus, have been unequivocally demonstrated to cont
Autor:
Nadeem A. Vellore, Michael W. Deininger, Brian J. Druker, Matthew S. Zabriskie, O’Hare Thomas, Christopher A. Eide
Publikováno v:
Blood. 126:1565-1565
ABL001 (Fig. 1) is a first-in-class allosteric inhibitor of BCR-ABL1 that occupies the vestigial myristoyl pocket, inducing an autoinhibited kinase conformation (Sellers, et al. Proceedings of the 106th Annual Meeting of the AACR; 2015 Apr 18-22; Phi
Publikováno v:
Blood. 122:372-372
Anthracylcine based regimens (i.e. cyclophosphamide, doxorubicin/epirubincin, vincristine and prednisone [CHOP/CEOP]) are standard chemotherapy in DLBCL and FL. On the other hand, the risk of anthracycline-induced cardiac toxicity (5%-26%) influences
Autor:
Thomas LaFramboise, Yasunobu Nagata, Masashi Sanada, Tsuyoshi Nakamaki, Kenichi Yoshida, Kathryn M Guinta, Yogen Saunthararajah, Lee-Yung Shih, Seishi Ogawa, Yuichi Shiraishi, Yusuke Sato, Jaroslaw P. Maciejewski, Bartlomiej P Przychodzen, Inés Gómez-Seguí, Satoru Miyano, Holleh D Husseinzadeh, Shuichi Miyawaki, Aiko Sato-Otsubo, Shigeru Chiba, Brittney Dienes, Chantana Polprasert, Hideki Makishima, Naoko Hosono, Mikkael A. Sekeres, Wolf-Karsten Hofmann, Swapna Thota, Matthew Ruffalo, Hiroko Tanaka, Kenichi Chiba
Publikováno v:
Blood. 122:518-518
Chromosomal aberrations and somatic mutations constitute key elements of the pathogenesis of myelodysplastic syndromes (MDS), a clonal hematologic malignancy characterized by cytopenias, a dysplastic bone marrow and propensity to clonal evolution. Ne
Autor:
Alexandra Poljak, Lothar Kanz, Stefan Wirths, Jonas S. Heitmann, Stefanie Bugl, Anjana Rao, Melanie Märklin, Bettina S, Hans-Georg Kopp, Martin Müller
Publikováno v:
Blood. 120:862-862
Abstract 862 NFAT is a family of highly phosphorylated proteins residing in the cytoplasm of resting cells. Upon dephosphorylation by calcineurin, NFAT proteins translocate to the nucleus where they orchestrate developmental and activation programs i
Non-MTC IGH-CCND1 Breakpoints in Mantle Cell Lymphoma Are Associated with CpG Sites and AID Hotspots
Autor:
Albert G. Tsai, Timothy C. Greiner, Harvey A. Greisman, Hye Son Yi, Zhengfei Lu, Michael R. Lieber
Publikováno v:
Blood. 118:398-398
Abstract 398 Most t(11;14)(q13;q32) breakpoints in mantle cell lymphoma (MCL) are scattered across a large genomic region centromeric to the CCND1 gene on chromosome 11q13. However, few t(11;14) breakpoints outside the major translocation cluster (MT