Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Smith, David A."'
Autor:
Alessandra Gaiba, David J. Spalding, Antoinette Naylor, Emma Louise Blaney, Vincent Bordas, Robert W. Ward, Richard L. Elliott, Smith David Glynn, Philip M. Green, Andrew K. Takle, Neil Stuart Garton, Jason Witherington
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(21)
A series of pyridone-N-benzyl-propanoic acids have been optimised to afford potent orally bioavailable VLA-4 antagonists.
Autor:
Brian Peter Slingsby, Andrew K. Takle, Alessandra Gaiba, Jason Witherington, Antoinette Naylor, Vincent Bordas, Anthony D. Rawlings, Smith David Glynn, Robert W. Ward
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(18)
A series of 6-heteroaryl-pyrazolo[3,4-b]pyridines has been optimised to afford potent inhibitors of Glycogen Synthase Kinase-3 (GSK-3). These analogues display excellent selectivity over the closely related Cyclin Dependant Kinase-2 (CDK-2).
Autor:
Brian Bolognese, Pearl Louis-Flamberg, Andrew Faller, Mark McCord, Lisa Marshall, Smith David Glynn, Ruth J. Mayer, Stuart Bailey, Derek Richard Buckle, Sally Jackson
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(1)
A series of hydroxamic acids related to the non-selective matrix metalloprotease inhibitor Batimastat is described, which inhibits the proteolytic cleavage of the low affinity IgE receptor from cell membrane preparations. Limited SAR studies suggest
Autor:
Sally Jackson, Lisa Marshall, Ruth J. Mayer, Andrew Faller, B. Bolognese, Stuart Bailey, Pearl Louis-Flamberg, Mark McCord, Smith David Glynn, Derek R. Buckle
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(1)
A series of hydroxamic acids related to the non-selective matrix metalloproteinase inhibitor Batimastat has been prepared, some members of which are potent inhibitors of the processing of the low affinity IgE receptor (CD 23). Increased activity is o