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Autor:
Jean-Luc Parent, Mannix Auger-Messier, Hugo Giguère, Julien Malette, Jade Degrandmaison, Guylain Boulay, Jonathan Berthiaume, Maude Frappier
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:1249-1259
Intact store-operated calcium entry (SOCE) mechanisms ensure the maintenance of Ca2+ homeostasis in cardiomyocytes while their dysregulation promotes the development of cardiomyopathies. To better understand this calcium handling process in cardiomyo
Autor:
Ettore Novellino, Valeria La Pietra, Rebecca Piccarducci, Sabrina Taliani, Federico Da Settimo, Deborah Pietrobono, Claudia Martini, Maria Letizia Trincavelli, Elisabetta Barresi, Simona Daniele, Luciana Marinelli, Chiara Giacomelli
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:737-749
The osteoblast generation from Mesenchymal stem cells (MSCs) is tightly coordinated by transcriptional networks and signalling pathways that control gene expression and protein stability of osteogenic “master transcription factors”. Among these p
Autor:
Maria Anele Romeo, Rossella Benedetti, Maria Saveria Gilardini Montani, Mara Cirone, Andrea Arena, Aurelia Gaeta
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1869:119168
The induction of DNA damage together with the interference with DNA repair represents a promising strategy in cancer treatment. Here we show that the PARP-1/2/3 inhibitor AZD2461 in combination with the CHK1 inhibitor UCN-01 altered the DNA damage re
Autor:
Julia Sirés-Campos, María Castejón-Griñán, Celia Jiménez-Cervantes, Concepción Olivares, Cecilia Herraiz, Marta Abrisqueta, José C. García-Borrón
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:76-94
Signaling from the melanocortin 1 receptor (MC1R), a Gs protein-coupled receptor (GPCR) crucial for melanocyte proliferation and differentiation, is regulated by cytosolic β-arrestins (ARRBs). MC1R signaling is also negatively modulated by the E3-ub
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:48-56
Posttranscriptional regulation process plays important roles in renal disease pathogenesis. AU-rich element RNA-binding protein (AUF1) interacts with and destabilizes mRNAs containing AU-rich elements (AREs) in their 3'UTR. The current study demonstr
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:158-171
Overexpression of γ-tubulin leads to the formation of filaments, but nothing is known about such filaments with regard to possible presence in cells, structure and probable dynamics. Here, we used mammalian cell lines to investigate the ability of
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:25-33
Epithelial ovarian cancer (EOC) frequently metastasises to the omentum, a process that requires pro-angiogenic activation of human omental microvascular endothelial cells (HOMECs) by tumour-secreted factors. We have previously shown that ovarian canc
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:12-24
The exposure and release of TF is regulated by post-translational modifications of its cytoplasmic domain. Here, the potential of Pin1 to interact with the cytoplasmic domain of TF, and the outcome on TF function was examined. MDA-MB-231 and transfec
Autor:
Shen Yue, Tianyuan Li, Steven Y. Cheng, Chen Liu, Ziyu Zhang, Yixing Yao, Nan Jin, Yue Wang, Tingting Yu, Hao Yin, Xin Yang, Yu Wang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1868:119124
Autophagy is a highly conservative self-digestion process to maintain intracellular homeostasis and to ensure the survival of cells under stress. Activation of Sonic Hedgehog (Shh) signaling depends on the normal endocytic degradation of pathway rece
Autor:
Marek Chadalski, Patryk Janus, Natalia Vydra, Anna Paszek, Michalina Gramatyka, Agnieszka Toma-Jonik, Wieslawa Widlak, Monika Pietrowska, Katarzyna Mrowiec
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1868:119086
The mouse 3110001I22Rik gene located in the first intron of Bfar is considered as a Bfar variant coding for the BFARv3 protein. However, it differs from other BFAR isoforms and resembles periphilin 1 (PPHLN1) due to its two (Lge1 and serine-rich) con