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pro vyhledávání: '"551"'
Autor:
Marshall M. Siegel, Mark Stahl, Kerry Kelleher, Ron Kriz, Robert M. Czerwinski, Ann Aulabaugh, Paul Wu, Laura Lin
Publikováno v:
Biochemistry. 48(9)
Bruton's tyrosine kinase (Btk) plays a central role in signal transduction pathways regulating survival, activation, proliferation, and differentiation of B-lineage lymphoid cells. A number of cell signaling studies clearly show that Btk is activated
Publikováno v:
Biochemistry. 51(46)
The protein kinase PKR is a key factor in innate immunity.1 In the presence of long stretches of A-form dsRNA, PKR is activated to undergo autophosphorylation.2,3 Once activated, PKR phosphorylates translation initiation factor eIF-2α, which blocks