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Autor:
Stepan Gambaryan, Valentina Shpakova, Alexandra Kharazova, Natalia Rukoyatkina, Igor Mindukshev, Alina Bogoutdinova
Publikováno v:
Biochemical and Biophysical Research Communications. 586:20-26
Curcumin is a natural polyphenol derived from the turmeric plant (Curcuma longa) which exhibits numerous beneficial effects on different cell types. Inhibition of platelet activation by curcumin is well known, however molecular mechanisms of its acti
Autor:
Ruyi Xue, Shengxian Li, Ji-Cheng Li, Lai-Xi Wang, W.W. Zhang, Youping Li, T.Y. Mi, X.L. Yin, Yueming Zhang, Hai-Tao Wang, Xu Shen, Yan Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 586:121-128
Postoperative fatigue (POF) is the most common and long-lasting complication after surgery, which brings heavy burden to individuals and society. Recently, hastening postoperative recovery receives increasing attention, but unfortunately, the mechani
Autor:
Akira Yamauchi, Keisuke Kitakaze, Shuichiro Okamoto, Kei Miyano, Hitomi Kato, Mizuho Kajikawa, Momoe Itsumi, Chikage Kawai, Futoshi Kuribayashi
Publikováno v:
Biochemical and Biophysical Research Communications. 587:78-84
An interaction between acute myeloid leukemia (AML) cells and endothelial cells in the bone marrow seems to play a critical role in chemosensitivity on leukemia treatment. The endothelial niche reportedly enhances the paracrine action of the soluble
Autor:
Li Li, Glenda C. Gobe, David A. Vesey, Christudas Morais, Rajagopalan Prasanna, Evan P. Owens, Hossam Kamli
Publikováno v:
Biochemical and Biophysical Research Communications. 586:42-48
Sunitinib is one of the first-line multi-tyrosine kinase inhibitors for metastatic renal cell carcinoma, and resistance to sunitinib continues to be a limiting factor for the successful treatment. As interleukin-6 (IL-6) is overexpressed in sunitinib
Publikováno v:
Biochemical and Biophysical Research Communications. 585:68-74
Aim To examine the effect of diacerein on vascular dysfunction in type 2 diabetic rats and elucidate the mechanism of diacerein. Methods In a rat model, type 2 diabetes was induced by high-fat diet and streptozotocin. Vascular function was assessed i
Autor:
Johanna Zerbib, Daniel Aberdam, Edward Pichinuk, Elie Frank, Léa Zennaro, Keren Oved, Orly Dorot, Lauriane N. Roux, Dominique Bremond-Gignac
Publikováno v:
Biochemical and Biophysical Research Communications. 582:100-104
Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function. Most of the patients suffer from aniridia-relat
Autor:
Junyi Zheng, Lei Wu, Per Olof Berggren, Yuqi Liu, Xiaoting Chen, Nanwei Tong, Juan Li, Zhenghao Wang, Ye Zhou, Xiaofeng Zheng, Ge Peng
Publikováno v:
Biochemical and Biophysical Research Communications. 581:110-117
Type 2 diabetes (T2D) is a multifactorial and polygenetic disease, although its exact etiology remains poorly understood. The objective of this study was to identify key biomarkers and potential molecular mechanisms in the development of T2D. Human R
Autor:
Atsushi Hoshino, Shunta Taminishi, Yoshito Minami, Satoaki Matoba, Ryota Urata, Tomohiro Hino, Takashi Nakagawa, Yohei Fushimura, Eri Iwai-Kanai, Satoru Furukawa
Publikováno v:
Biochemical and Biophysical Research Communications. 585:191-195
Impairment of pancreatic β cells is a principal driver of the development of diabetes. Restoring normal insulin release from the β cells depends on the ATP produced by the intracellular mitochondria. In maintaining mitochondrial function, the tumor
Publikováno v:
Biochemical and Biophysical Research Communications. 577:158-164
Sorafenib is a tyrosine kinase inhibitor that shows anti-tumour effects against various cancers including gastric cancer (GC). However, the clinical application of sorafenib is often hampered by drug resistance. Sirtuins 6 (SIRT6) is a member of the
Autor:
Gabrielle Walsh, Wenshuo Zhou, Alexei Medvedev, Barbara K. Felber, Sanjai Kumar, Jasper Perry-Anderson, Victoria Majam, Konstantin Virnik, Ira Berkower
Publikováno v:
Biochem Biophys Res Commun
There is an urgent need for a malaria vaccine that can prevent severe disease in young children and adults. Despite earlier work showing an immunological mechanism for preventing infection and reducing disease severity, there is currently no reliable