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Publikováno v:
Biochemical and Biophysical Research Communications. 561:7-13
Doxorubicin (DOX) is a broad-spectrum antineoplastic drug; however, its serious cardiotoxic side effects in inflammatory responses limit its use in clinical applications. Dopamine D1 receptor (DRD1), a G protein-coupled receptor, is crucial for the d
Autor:
Weng-Onn Lui, Robin Fröbom, Erik Berglund, Catharina Larsson, Robert Bränström, Inga Lena Nilsson, Craig A. Aspinwall
Publikováno v:
Biochemical and Biophysical Research Communications. 557:14-19
The ATP-regulated K+ channel (KATP) plays an essential role in the control of many physiological processes, and contains a ATP-binding site. Tyrosine kinase inhibitors (TKI) are commonly used drugs, that primarily target ATP-binding sites in tyrosine
Autor:
Vijay Kumar, Danish Idrees
Publikováno v:
Biochemical and Biophysical Research Communications
The post-infection of COVID-19 includes a myriad of neurologic symptoms including neurodegeneration. Protein aggregation in brain can be considered as one of the important reasons behind the neurodegeneration. SARS-CoV-2 Spike S1 protein receptor bin
Autor:
John G. Kingma, Ismail Laher
Publikováno v:
Biochemical and Biophysical Research Communications. 540:56-60
Sex dependent differences in coronary artery vasoregulation may be due to variations in responses to endogenous vasoactive compounds including endothelin (ET-1) and nitric oxide (NO).Septal coronary arteries (200 μm) from healthy, sexually mature ma
Publikováno v:
Biochemical and Biophysical Research Communications. 530:644-650
Melatonin has been implicated in the regulation of bone metabolism; however, the molecular mechanisms underlying its involvement in fracture healing are still obscure. We previously developed an in vivo fracture healing model using the scale of a dou
Autor:
Vidita A. Vaidya, Antara A. Banerjee
Publikováno v:
Biochemical and Biophysical Research Communications. 531:609-614
The 5-HT2A receptor is a target for hallucinogenic and non-hallucinogenic ligands that evoke unique behavioral, electrophysiological and molecular consequences. Here, we explored the differential effects of distinct 5-HT2A receptor ligands on signali
Publikováno v:
Biochemical and Biophysical Research Communications. 530:181-188
Desensitization of G protein-coupled receptors (GPCRs) represents a gradual attenuation of receptor responsiveness by continuous or repeated exposure to agonists. The most widely accepted molecular mechanism responsible for desensitization is that of
Publikováno v:
Biochemical and Biophysical Research Communications. 529:283-288
Our previous reports demonstrated that the novel peroxisome proliferator-activated receptors α and γ (PPARα/γ) dual agonist propane-2-sulfonic acid octadec-9-enyl-amide (N15) alleviates cognitive ability in the chronic phase of ischemic stroke. H
Autor:
Kento Ogawa, Hiroyuki Koyama, Daisuke Aotani, Kenro Imaeda, Hiromi Kataoka, Tomohiro Tanaka, Takashi Yagi, Hideomi Ohguchi, Katsushi Takeda, Tingting Guo
Publikováno v:
Biochemical and Biophysical Research Communications. 524:385-391
Pemafibrate, a selective peroxisome proliferator-activated receptor (PPAR) α modulator, is a new drug that specifically modulates PPARα conformation and co-activator recruitment, thereby lowers plasma triglycerides with less off-target effects. Cla
Publikováno v:
Biochemical and Biophysical Research Communications. 523:887-893
pH-sensitive polyethylene glycol-conjugated urokinase nanogels (PEG-UK) is a new form of urokinase (UK) nanogels that could release UK at certain pH values. In our former study, we demonstrated that the pH value in the infarcted brain significantly d