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Publikováno v:
Biochemical and Biophysical Research Communications. 495:382-387
The NOD-like receptor family, pyrin domain–containing protein 3 (NLRP3) inflammasome plays an important role in the development of atherosclerosis. The activated NLRP3 inflammasome has been reported to promote macrophage foam cell formation, but no
Publikováno v:
Biochemical and Biophysical Research Communications. 495:1317-1321
The induction of hypoxia inducible factor (HIF) and autophagy are important cellular responses to hypoxia. The production of erythropoietin (EPO) regulated by HIF is increased by hypoxia and participates in cell protection in various organs and tissu
Publikováno v:
Biochemical and Biophysical Research Communications. 494:728-735
Myocardial ischemia-reperfusion (I/R) injury always occur during the recovery of myocardial blood supply with high morbidity and mortality. Although, various therapeutic schedules were applied in clinic, there are real problems that have to be resolv
Autor:
Lingjian Yang, Xiaohui Zheng, Liujiao Bian, Yuxin An, Xiaokang Gao, Haiyang Gao, Xinfeng Zhao, Sha Liao, Qian Li
Publikováno v:
Biochemical and Biophysical Research Communications. 494:634-640
The β2 adrenergic receptor (β2-AR) is a prototypical family A G protein-coupled receptor (GPCR) and an excellent model system for studying the mechanism of GPCR activation. Purified β2-AR was immobilized on macroporous silica gel to obtain liquid
Autor:
Asuka Inoue, Yuko Otani, Keita Satoh, Junken Aoki, Yuji Shinjo, Kuniyuki Kano, Kumiko Makide, Fumiya Fukami, Tomohiko Ohwada
Publikováno v:
Biochemical and Biophysical Research Communications. 494:332-338
Lysophosphatidylserine (LysoPS) has been shown to have lipid mediator-like actions to induce mast cell degranulation and suppress T lymphocyte proliferation. Recently, three G protein-coupled receptors (GPCRs), LPS1/GPR34, LPS2/P2Y10, and LPS3/GPR174
Publikováno v:
Biochemical and Biophysical Research Communications. 493:451-454
GPR12 is a constitutively active, Gs protein-coupled receptor that currently has no confirmed endogenous ligands. GPR12 may be involved in physiological processes such as maintenance of oocyte meiotic arrest and brain development, as well as patholog
Publikováno v:
Biochemical and Biophysical Research Communications. 490:55-61
To date the molecular mechanism of cardiac hypertrophy has not been completely elucidated. Since oxidized low-density lipoprotein (ox-LDL) is considered a risk marker for early ventricular remodeling, we speculated that ox-LDL may be related to cardi
Autor:
Benjamin Y, Klein, Hadassah, Tamir, Robert J, Ludwig, Sara B, Glickstein, Martha G, Welch, M, Anwar
Publikováno v:
Biochemical and Biophysical Research Communications. 487:47-53
Little is known about the role of oxytocin (OT) in colostrum during early gut colonization. We previously showed that transient OT receptor (OTR) expression on newborn rat enterocytes coincides with the milk-suckling period, and that OT activates end
Autor:
Xiaoyang Hu, Qian Liu, Teng Zhang, Jingzhen Zhu, Qingqing Wang, Xingyou Dong, Longkun Li, Chao Wu, Zhenxing Yang
Publikováno v:
Biochemical and Biophysical Research Communications. 485:535-541
EP3 is a receptor for prostaglandin E2 (PGE2), and although its effect on bladder excitability has attracted considerable attention, the underlying mechanism remains unclear. To investigate whether the hyperpolarization-activated cyclic nucleotide-ga
Publikováno v:
Biochemical and Biophysical Research Communications. 483:1166-1177
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to be a promising therapeutic target for several neurodegenerative disorders, which includes Parkinson disease, Alzheimer's disease, Huntington disease and Amyot