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Publikováno v:
Biochemical and Biophysical Research Communications. 573:42-47
Cisplatin is an approved cancer therapeutic drug used to treat many solid tumors but its accumulation in the kidney, which causes nephrotoxicity, limits its clinical use. Therefore, investigators seek new alternatives to cisplatin that may be more ef
Publikováno v:
Biochemical and Biophysical Research Communications. 572:27-34
Postoperative delirium (POD), a syndrome of confusion and inattention, frequently occurs after anesthesia and surgery. The prefrontal cortex (PFC) plays key roles in executive functions and cognitive controls. However, the neuropathogenesis of POD in
Publikováno v:
Biochemical and Biophysical Research Communications. 571:74-80
Transient global cerebral ischemia (tGCI) is a cerebrovascular disorder characterized by a brief decline in blood flow, neurological deficits, and is often predictive of stroke. Theobromine (TBR) is consumed worldwide in chocolates, tea, and cocoa pr
Publikováno v:
Biochemical and Biophysical Research Communications. 567:79-85
circRNAs have been suggested to modulate NSCLC tumorigenesis and drug resistance. Whether circSNX6 affects NSCLC remains unclear. In this study, we aim to investigate the role of circSNX6 in drug resistance of NSCLC exposed to cisplatin. RT-qPCR meth
Publikováno v:
Biochemical and biophysical research communications. 560:1-6
Cancer immunotherapy, especially treatment with monoclonal antibodies (mAbs) that block programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) signaling, has attracted attention as a new therapeutic option for cancer. However, only a l
Publikováno v:
Biochemical and Biophysical Research Communications. 553:119-125
Excessive activation of inflammation in chondrocyte has been considered to be a major reason cause of cellular death and degeneration in osteoarthritis (OA) development. The NLRP3 inflammasome-mediated pyroptosis pathway is closely related to inflamm
Publikováno v:
Biochemical and Biophysical Research Communications. 554:151-157
It has been suggested that the intelligence quotient of children born to pregnant women taking 1000 mg or more of valproic acid per day is lower than that of children born to pregnant women taking other antiepileptic drugs. However, the mechanism whe
Autor:
S. G. Gaidin, A. I. Sergeev, Valery P. Zinchenko, Artem M. Kosenkov, I. Yu. Teplov, Miroslav N. Nenov
Publikováno v:
Biochemical and Biophysical Research Communications. 553:99-106
Spontaneous burst firing is a hallmark attributed to the neuronal network activity. It is known to be accompanied by intracellular calcium [Са2+]i oscillations within the bursting neurons. Studying mechanisms underlying regulation of burst firing i
Publikováno v:
Biochemical and Biophysical Research Communications. 550:77-83
Osteosarcoma (OS) is the most common type of bone tumor that seriously affects limb function and induces great pain in patients. Lung metastasis and chemotherapy resistance are two key issues leading to the poor prognosis of OS patients, therefore ne
Publikováno v:
Biochemical and Biophysical Research Communications. 547:36-43
Pain is a major complication of cancer and significantly affects the quality of life. Cerebrospinal fluid-contacting nucleus (CSF-CN) has been reported to be involved in the development of neuropathic pain and inflammatory pain. However, whether CSF-