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Publikováno v:
Biochemical and Biophysical Research Communications. 529:57-63
Mucin-type O-glycosylation (hereafter referred to as O-GalNAc glycosylation) is one of the most abundant glycosylation on proteins. It is initiated by the members of polypeptide N-acetyl-α-galactosaminyltransferases (ppGalNAc-Ts) family. The ppGalNA
Publikováno v:
Biochem Biophys Res Commun
Propofol is a clinically important intravenous anesthetic. We previously reported that it directly inhibited 5-lipoxygenase (5-LOX), a key enzyme for leukotriene biosynthesis. Because the hydroxyl group in propofol (propofol 1-hydroxyl) is critical f
Autor:
Enrique Rudiño-Piñera, Claudia Rodríguez-Almazán, Jesús Silva-Sánchez, Víctor Cifuentes-Castro
Publikováno v:
Biochemical and Biophysical Research Communications. 522:545-551
β-lactamases are the main molecules responsible for giving bacterial resistance against β-lactam antibiotics. The study of β-lactamases has allowed the development of antibiotics capable of inhibiting these enzymes. In this context, extended spect
Autor:
Brett D. Noerager, J.E. Blalock, Tomasz Szul, Matthew T. Hardison, Xin Xu, Preston E. Bratcher, Liliana Viera, Kristopher R. Genschmer, Derek W Russell, M. Abdul Roda, Amit Gaggar
Publikováno v:
Biochem Biophys Res Commun
Neutrophil influx and activation contributes to organ damage in several major lung diseases. This inflammatory influx is initiated and propagated by both classical chemokines such as interleukin-8 and by downstream mediators such as the collagen frag
Autor:
Guang Yang, Ying Yuan, Lina Zhao, Yu Geng, Haolin Yun, Xiaodong Zhang, Yufei Wang, Hong-feng Yuan
Publikováno v:
Biochemical and biophysical research communications. 560
Aspirin can efficiently inhibit the glycolysis and proliferation of cancer cells, however, the underlying mechanism is poorly understood. Here, we report that aspirin attenuates the glycolysis and proliferation of hepatoma cells through modulating th
Publikováno v:
Biochemical and Biophysical Research Communications. 512:314-318
Plasmin is a potent serin protease involved in a variety of biological functions, such as fibrinolysis and tissue remodeling. On performing an in vitro control assay to measure the activity of endogenous plasmin in cell lysates, a stimulatory effect
Autor:
Yuri M. Poluektov, Irina Yu. Petrushanko, Olga D. Lopina, E. A. Dergousova, Alexander A. Makarov, Vladimir A. Mitkevich
Publikováno v:
Biochemical and Biophysical Research Communications. 510:86-90
The functioning of the N, K-ATPase depends on the redox status of cells and its activity is inhibited by oxidative stress and hypoxia. We previously found that redox sensitivity of the Na,K-ATPase is mediated by glutathionylation of the α-subunit. A
Publikováno v:
Biochemical and Biophysical Research Communications. 509:249-254
Epigenetic modifiers such as decitabine (DAC), a DNA methyltransferase inhibitor, have the potential benefit of combination therapy with conventional anti-cancer drugs. This study was aimed to clarify whether DAC at the low concentration without cyto
Autor:
Razieh Yazdanparast, Nona Boostan
Publikováno v:
Biochemical and Biophysical Research Communications. 506:891-894
Background Gamma aminobutyric acid (GABA), an inhibitory neurotransmitter, is produced via decarboxylation of l -glutamate through the glutamic acid decarboxylase (GAD) enzyme. The synchronic action of GABA-transaminase (GABA-T) and succinic semialde
Autor:
Ayu Masyita, Takayuki Kuraishi, Rangga Meidianto Asri, Firzan Nainu, Aki Hori, Emil Salim, Yusnita Rifai, Risfah Yulianty, Mochammad Hatta
Publikováno v:
Biochemical and biophysical research communications. 547
Excessive melanin formation has been linked to various skin disorders such as hyperpigmentation and skin cancer. Tyrosinase is the most prominent target for inhibitors of melanin production. In this study, we investigated whether arbutin and its prod