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Publikováno v:
Biochem Biophys Res Commun
Serine proteases are fundamental components of biology, including innate immunity, which is systematically orchestrated in an orderly, balanced fashion in the healthy host. Such serine proteases are found in two well-recognized pathways of an innate
Autor:
Aditya K. Padhi, Timir Tripathi
Publikováno v:
Biochemical and Biophysical Research Communications
Several existing drugs are currently being tested worldwide to treat COVID-19 patients. Recent data indicate that SARS-CoV-2 is rapidly evolving into more transmissible variants. It is therefore highly possible that SARS-CoV-2 can accumulate adaptive
Autor:
Zhixiong Zhang, Shaoxue Zeng, Yuxi Wang, Chengyong Wu, Wen Shuai, Qingjie Xiao, Ting Xue, Ting Zhang, Bo Sun
Publikováno v:
Biochemical and Biophysical Research Communications. 534:330-336
Microtubule is a key component of cytoskeleton and has been considered as an important target for the treatment of cancer. In particular, the tubulin taxane-site inhibitors such as taxol analogs and epothilones have achieved great success in clinical
Publikováno v:
Biochemical and Biophysical Research Communications. 532:265-270
Methotrexate (MTX) has been widely used for the treatment of many types of autoimmune diseases, such as rheumatoid arthritis, psoriasis and dermatomyositis. However, its pharmacological mechanism is still unclear completely. In this study, we found t
Publikováno v:
Biochem Biophys Res Commun
Propofol is a clinically important intravenous anesthetic. We previously reported that it directly inhibited 5-lipoxygenase (5-LOX), a key enzyme for leukotriene biosynthesis. Because the hydroxyl group in propofol (propofol 1-hydroxyl) is critical f
Autor:
Lewis Byrom, Jeff Jerman, Egle Gaurilcikaite, Alistair Mathie, Paul D. Wright, David McCoull, Jonathan M. Large, Barbara W. Hadrys, Yvonne Walsh, Emma L. Veale
Publikováno v:
Biochemical and Biophysical Research Communications. 520:35-40
TREK2 (KCNK10, K2P10.1) is a two-pore domain potassium (K2P) channel and a potential target for the treatment of pain. Like the majority of the K2P superfamily, there is currently a lack of useful pharmacological tools to study TREK2. Here we present
Autor:
Toru Nyunoya, Rajan T. Reddy
Publikováno v:
Biochem Biophys Res Commun
Cigarette smoke (CS) contains many toxins that collectively harm nearly every organ in the body, and smoking is a key risk factor for many chronic diseases. Aside from its toxic actions, CS may alter expression of the drug- and steroid-binding pregna
Autor:
Kenji Maeda, Satoru Kohgo, Shin-ichiro Hattori, Noriko Tamura, Hiroaki Mitsuya, Kouki Matsuda, Yoshiaki Yasutake
Publikováno v:
Biochemical and Biophysical Research Communications. 509:943-948
Nucleoside analogue reverse transcriptase (RT) inhibitors (NRTIs) are major antiviral agents against hepatitis B virus (HBV) and human immunodeficiency virus type-1 (HIV-1). However, the notorious insoluble property of HBV RT has prevented atomic-res
Autor:
Yuri M. Poluektov, Irina Yu. Petrushanko, Olga D. Lopina, E. A. Dergousova, Alexander A. Makarov, Vladimir A. Mitkevich
Publikováno v:
Biochemical and Biophysical Research Communications. 510:86-90
The functioning of the N, K-ATPase depends on the redox status of cells and its activity is inhibited by oxidative stress and hypoxia. We previously found that redox sensitivity of the Na,K-ATPase is mediated by glutathionylation of the α-subunit. A
Publikováno v:
Biochemical and Biophysical Research Communications. 503:2833-2840
Atherosclerosis is a chronic inflammatory disease involved in endothelial dysfunction. Pyroptosis is a pro-inflammatory form of cell death and plays pivotal roles in atherosclerosis. MicroRNAs (miRNAs) are implicated in atherosclerosis, however the m