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Publikováno v:
Biochemical and Biophysical Research Communications. 262:76-79
Hepatocyte growth factor (HGF), a potent mitogen, is released into plasma at increased levels following injury to certain tissues, including the liver. Early increases in plasma HGF are not due to a release from the injured liver, but rather from dis
Heterogeneity of Binding Sites and Bioeffects of Raloxifene on the Human Leukemic Cell Line FLG 29.1
Autor:
U. Frediani, Valentina Martineti, Maria Luisa Brandi, Susanna Benvenuti, Sandra Zecchi, Lucia Formigli, Francesca Gori, Gianna Fiorelli
Publikováno v:
Biochemical and Biophysical Research Communications. 240:573-579
The benzothiophene divarative raloxifene is known to mimic estrogen in human bone remodeling. To investigate the "in vitro" properties of raloxifene on osteoclast precursors, the human leukemic cell line FLG 29.1, which differentiates toward the oste
Publikováno v:
Biochemical and Biophysical Research Communications. 214:1121-1129
In this study a protein expression system was used to synthesize recombinant human serum albumin containing a mutation that has been shown to result in familial dysalbuminemic hyperthyroxinemia. Equilibrium dialysis was used to measure the binding of
Publikováno v:
Biochemical and Biophysical Research Communications. 304:755-757
Epinephrine is known to be rapidly oxidized during sepsis. Ischemia and acidosis, which often accompany sepsis, are associated with the release of weakly bound cupric ions from plasma proteins. We investigated whether copper promotes oxidation of epi
Autor:
N.J. Goulding, P.M. Guyre
Publikováno v:
Biochemical and Biophysical Research Communications. 192:351-358
The anti-inflammatory protein lipocortin 1 has been proposed as a mediator of some of the anti-inflammatory actions of glucocorticoid hormones. In view of reported glucocorticoid effects on leukocyte Fc gamma receptors, the effect of short-term lipoc
Autor:
Virinder K. Moudgil, Madhavi Gunda
Publikováno v:
Biochemical and Biophysical Research Communications. 174:1239-1247
We have examined the influence of sulfhydryl (SH)-group modifying agents on the interaction of the rat liver glucocorticoid receptor (GR) with its known agonist triamcinolone acetonide (TA) and the newly synthesized antagonist mifepristone (RU486). I
Publikováno v:
Biochemical and Biophysical Research Communications. 174:181-188
Thrombin has been shown to cause in vitro bone resorption and to stimulate osteoblastic cell proliferation, phosphoinositide turnover and cytosolic calcium levels. In the present study, the role of the active site of thrombin in its action on osteobl
Publikováno v:
Biochemical and biophysical research communications. 289(5)
The mechanism underlying increased AVP synthesis and release in glucocorticoid deficiency is not known. Therefore, the present study was undertaken to investigate whether the mechanism was at the level of AVP gene transcription. The AVP gene promoter
Autor:
Anna Palumbo, Marco d'Ischia
Publikováno v:
Biochemical and biophysical research communications. 282(3)
Two established antithyroid drugs, 6-propyl-2-thiouracil and 6-methyl-2-thiouracil, as well as S-methylthiouracil, are shown to be competitive inhibitors of nitric oxide synthase (NOS) (K(I) values ranging from 14 to 60 microM), with moderate selecti
Publikováno v:
Biochemical and biophysical research communications. 237(2)
Maintenance of rats on a vitamin A-deficient diet resulting in undetectable levels of plasma retinol and significant reductions in relative testes weight compared to age-matched controls leads to the loss of liver membrane-bound low affinity glucocor