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Autor:
Hiroki Kato, Masataka Horiuchi, Takashi Fujita, Mitsutoshi Yoneyama, Koji Onomoto, Kiyohiro Takahasi
Publikováno v:
Biochemical and Biophysical Research Communications. 517:662-669
Upon viral infection, retinoic acid-inducible gene-I (RIG-I)-like receptors detect viral foreign RNAs and transmit anti-viral signals via direct interaction with the downstream mitochondrial adaptor molecule, interferon (IFN)-β promoter stimulator-1
Autor:
Fusako Miyamoto, Takeshi Naito, Hua Qian, Kumi Kawaji, Toshio Hattori, Eiichi Kodama, Nobutaka Fujii, Shinya Oishi, Kazumi Kajiwara, Kentaro Watanabe, Masao Matsuoka, Xiaoguang Li
Publikováno v:
Biochemical and Biophysical Research Communications. 424:257-261
The lack of small animal models for the evaluation of anti-human immunodeficiency virus type 1 (HIV-1) agents hampers drug development. Here, we describe the establishment of a simple and rapid evaluation system in a rat model without animal infectio
Publikováno v:
Biochemical and biophysical research communications. 462(4)
Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors (GPCRs) that are activated by the agonists acetylcholine and muscarine and blocked by several antagonists, among them atropine. In mammals five mAChRs (m1-m5) exist of which
Autor:
Tae-ho Jang, Eijaz Ahmed Bhat, Eun Kyung Seo, Chang Min Kim, Jae Young Choi, Hyun Ho Park, Jun Hyuck Lee
Publikováno v:
Biochemical and biophysical research communications. 460(4)
Inflammatory caspases, such as caspase-1, which is critical for the innate immune response, are activated upon the formation of a molecular complex called the inflammasome. The inflammasome is composed of three proteins, the Nod-like receptor (NLRP,
Autor:
Aruna Asipu, Asipu Sivaprasadarao, Christopher J. Partridge, Lindsey A. Mair, Malcolm Hunter, Andrew Smith
Publikováno v:
Biochemical and Biophysical Research Communications. 348:1123-1131
ATP-sensitive potassium (KATP) channels play a central role in glucose-stimulated insulin secretion (GSIS) by pancreatic beta-cells. Activity of these channels is determined by their open probability (Po) and the number of channels present in a cell.
Autor:
Wei Wang, Yu Qiu, Kyu Young Song, Cheol Kyu Hwang, Chun Sung Kim, Horace H. Loh, Li Na Wei, Ping-Yee Law, Hack Sun Choi
Publikováno v:
Biochemical and Biophysical Research Communications. 343:1132-1140
The pharmacological actions of morphine and morphine-like drugs, such as heroin, mediate primarily through the mu-opioid receptor (MOR). It has been proposed that the functional diversity of MOR may be related to alternative splicing of the MOR gene.
Autor:
Yoshikazu Koyama, Hidekazu Nakabayashi, Shinzo Nishi, Hong Mei Li, Norman C.W. Wong, Masaharu Sakai
Publikováno v:
Biochemical and Biophysical Research Communications. 287:160-172
Glucocorticoids inhibit rodent alpha-fetoprotein (AFP) gene activity but stimulate expression of the human homologue. Like human, activity of the AFP promoter from other primates was stimulated by the synthetic glucocorticoid dexamethasone (Dex) in v
Publikováno v:
Biochemical and Biophysical Research Communications. 275:77-83
Proteinase-activated receptors (PARs) are activated by proteolytic removal of a short amino terminal peptide, thus exposing a new amino terminus that functions as a tethered ligand that activates the receptor. With the aim to identify and study poten
Autor:
Masaaki Mori, Yukio Shimomura, Tsutomu Kurokawa, Yasuhiro Sumino, Yoshihiro Ishibashi, Haruo Onda, Michiko Abe, Masahiko Fujino, Tsukasa Sugo, Osamu Nishimura
Publikováno v:
Biochemical and Biophysical Research Communications. 261:622-626
Melanin-concentrating hormone (MCH), which is an orexigenic peptide, was isolated and identified as the endogenous ligand of the SLC-1 receptor. We established a CHO cell line expressing the rat SLC-1 receptor to search for its endogenous ligand. The
Publikováno v:
Biochemical and Biophysical Research Communications. 235:201-204
In the T47D human breast cancer cell line, Taxol was found to compete for ethylketocyclazocine opioid binding (IC503.3 pM). In contrast, no interaction of the drug with [3H]diprenorphine binding occurred. Binding was multiphasic, in the absence of co