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Publikováno v:
Biochemical and biophysical research communications. 560:1-6
Cancer immunotherapy, especially treatment with monoclonal antibodies (mAbs) that block programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) signaling, has attracted attention as a new therapeutic option for cancer. However, only a l
Autor:
Masakazu Shinohara, Makoto Imamori, Wataru Ogawa, Tetsuya Hosooka, Yusei Hosokawa, Kei Yoshino, Chikako Aoki
Publikováno v:
Biochemical and Biophysical Research Communications. 557:62-68
Clinical and animal studies have suggested a possible beneficial effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH). Although SGLT2 inhibitors have bee
Autor:
Chikako Nishigori, Ikuko Yano, Tsutomu Nakagawa, Takeshi Hirano, Toshinori Bito, Takahiro Ishida, Kazuhiro Yamamoto, Hiroaki Shichiri, Midori Hirai, Maya Tokura, Atsushi Uda
Publikováno v:
Biochemical and Biophysical Research Communications. 485(2):227-233
Hand-foot skin reaction (HFSR) is a common side effect of multiple tyrosine kinase inhibitors (mTKIs). HFSR can necessitate dose reductions or interruption of therapy owing to its negative effect on the quality of life. Therefore, effective use of mT
Autor:
Jeong-Hwan Yoon, Masahiko Kuroda, Keiji Miyazawa, Eunjin Bae, Tatsuo Ohira, Mitsuyasu Kato, Mizuko Mamura, Yojiro Makino, Norihiko Ikeda
Publikováno v:
Biochemical and biophysical research communications. 484(2):269-277
Cancer-associated inflammation develops resistance to the epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancers (NSCLCs) harboring oncogenic EGFR mutations. Stat3-mediated interleukin (IL)-6 signalin
Publikováno v:
Biochemical and Biophysical Research Communications. 477(3):515-519
Patients with pancreatic ductal adenocarcinoma (PDAC) commonly require chemotherapy because they frequently develop metastatic disease or locally advanced tumors. Gemcitabine, an analogue of cytosine arabinoside, is commonly used for PDAC treatment.
Autor:
Yuichi Kitai, Kanako Okabe, Osamu Ikeda, Misa Nakasuji, Ryuta Muromoto, Shigeyuki Kon, Sumihito Togi, Kenji Oritani, Tadashi Matsuda
Publikováno v:
Biochemical and biophysical research communications. 463(3):395-400
Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA), which interacts with cellular proteins, plays a central role in modification of viral and/or cellular gene expression. Here, we show that LANA associate
Autor:
Yuki Tanaka, Takeshi Niki, Shizuma Ishikawa, Hiroyoshi Ariga, Kazuko Takahashi-Niki, Sanae M.M. Iguchi-Ariga
Publikováno v:
Biochemical and Biophysical Research Communications. 421(4):813-818
Loss-of-functional mutation in the DJ-1 gene causes a subset of familial Parkinson’s disease. The mechanism underlying DJ-1-related selective vulnerability in the dopaminergic pathway is, however, not known. Dopamine is synthesized by two enzymes a
Autor:
Juanita H. J. Vernooy, Jane A. Haydock, Emiel F.M. Wouters, Geja J. Hageman, Astrid Haegens, Karen Brauers, Liesbeth Geraets, Aalt Bast
Publikováno v:
Biochemical and Biophysical Research Communications, 382(3), 598-603. Elsevier
In the present study, the anti-inflammatory effects of the flavonoids flavone, fisetin and tricetin were evaluated in a mouse model of LPS-induced acute pulmonary inflammation. The flavonoid fisetin significantly reduced lung myeloperoxidase-levels a
Autor:
Emiel F.M. Wouters, Anika A. M. Vaarhorst, Liesbeth Geraets, Harald J.J. Moonen, Aalt Bast, Geja J. Hageman
Publikováno v:
Biochemical and Biophysical Research Communications, 338(4), 1805-1810. Elsevier
Oxidative DNA damage, as occurs during exacerbations in chronic obstructive pulmonary disease (COPD), highly activates the nuclear enzyme poly(ADP-ribose)polymerase-1 (PARP-1). This can lead to cellular depletion of its substrate NAD(+), resulting in
Autor:
Yukio Kato, Takeshi Hashimoto, Tomoko Sugiura, Kazumi Masuda, Hisashi Takakura, Yasuro Furuichi, Yoshiteru Hanai
Publikováno v:
Biochemical and Biophysical Research Communications. 418(4):774-749
Highlights: Black-Right-Pointing-Pointer Muscle contraction augmented carnitine uptake into rat hindlimb muscles. Black-Right-Pointing-Pointer An increase in carnitine uptake was due to an intrinsic clearance, not blood flow. Black-Right-Pointing-Poi