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Autor:
Jianxin Yang, Yuxiao Tang, Chuyang Ye, Hui Shen, Mengyu Cai, Fengfeng Mo, Hongxia Li, Yinyin Zhang, Hongtao Lu, Xin Xu
Publikováno v:
Behavioural brain research. 418
Background Chronic stress is one of the most important causes of depression, accompanied by neuroinflammation and hippocampal injuries. Long-term elevation of glucocorticoid leads to activation of NF-κB and inhibition of GPR39/CREB/BDNF pathway, whi
Role of the cAMP-PKA-CREB-BDNF pathway in abnormal behaviours of serotonin transporter knockout mice
Publikováno v:
Behavioural brain research. 419
Serotonin transporter gene-linked polymorphic region polymorphisms are associated with anxiety, neuroticism, affective disorders and vulnerability to stressful life events; however, the relevant physiological mechanisms are not well understood. Serot
Publikováno v:
Behavioural brain research. 417
In previous research, we found that chronic-intermittent ethanol administration (CIEA), a model of binge drinking, impaired emotional memory in mice, and this impairment was counteracted by the anti-inflammatory drug indomethacin. In the present stud
Publikováno v:
Behavioural brain research. 417
Background The link between maternal immune activation (MIA) and the risk of developing schizophrenia (SCZ) later in life has been of major focus in recent years. This link could be bridged by activated inflammatory pathways and excessive cytokine re
Publikováno v:
Behavioural brain research. 416
Hypobaric Hypoxia (HH) is known to cause oxidative stress in the brain that leads to spatial memory deficit and neurodegeneration . For decades therapeutic hypothermia is used to treat global and focal ischemia in preserving brain functions that prov
Publikováno v:
Behav Brain Res
Cotinine is the major metabolite of nicotine and has recently been shown to be self-administered intravenously by rats. However, mechanisms underlying cotinine self-administration remained unknown. Mesolimbic dopamine system projecting from the ventr
Autor:
Angela Maria Casaril, Darling de Andrade Lourenço, Micaela Domingues, Beatriz Vieira, Lucielli Savegnago, Suely Ribeiro Bampi, Paloma Taborda Birmann, César Augusto Brüning, Tiago Collares, Mariana Souza Sonego, Luiz H. Dapper, Fabiana Kömmling Seixas, Eder J. Lenardão
Publikováno v:
Behavioural Brain Research. 366:96-107
In the last decades, selenium-containing compounds have received increasing attention due to their various biological and pharmacological properties. In the present study, we investigated the effects of 3-[(4-methoxyphenyl) selanyl]-2-phenylimidazo[1
Autor:
Cristian Gerónimo-Olvera, Lucía Quevedo-Corona, Mireya Alcaraz-Zubeldia, Francisca Pérez-Severiano, Juan Carlos Martínez-Lazcano, Alicia Sánchez-Mendoza, M. Alejandra Hernández-Melesio, Camilo Ríos, María E. Jiménez-Capdeville, Martha E. Santoyo-Pérez
Publikováno v:
Behavioural Brain Research. 366:108-117
Nitric oxide (NO) plays a leading role in learning and memory processes. Previously, we showed its ability to modify the deleterious effect of immunotoxin 192 IgG-saporin (192-IgG-SAP) in the cholinergic system. The aim of this study was to analyze t
Publikováno v:
Behavioural Brain Research. 367:128-142
Estrogens receptors (ER) are involved in several sociosexual behaviors and fear responses. In particular, the ERα is important for sexual behaviors, whereas ERβ modulates anxiolytic responses. Using shRNA directed either against the ERα or the ER
Autor:
Yanli Zhang, Fengrui Cao, Qing Liu, Shansong Yi, Jianmei Ma, Xiaohan Yang, Xinsheng Li, Fenghua Xu, Kai Fan, Gang Liu, Xinnan Zhao, Guoyang Xu
Publikováno v:
Behavioural Brain Research. 364:494-502
The immuno-inflammatory activation triggered by various stresses play an important role in pathophysiology of depression. The immune responses display differential pathological characters in different stresses. However, comparative data and analysis