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Autor:
Rishi Batra, Trevor Meisinger, Zhibo Liu, Wanfen Xiong, B. Timothy Baxter, Matthew Fitzgerald
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Marfan syndrome (MFS) is a heritable disorder of connective tissue, caused by mutations in fibrillin-1 gene. Pulmonary emphysema is one of the most common manifestations in MFS. However, the pathogenesis and molecular mechanism of pulmonary emphysema
Autor:
Michael V. McConnell, Mitsuaki Isobe, Joshua M. Spin, Hisanori Kosuge, Yadon Arad, Toshinobu Saito
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Background: Oxidative stress plays a key role in the development of atherosclerosis. N-acetylcysteine (NAC) has the potential to reduce oxidative stress and inflammation, but has a short half-life and low oral bioavailability. We studied a sustained-