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Autor:
Eunjoo Kim, Susan K. Mathai, Ian T. Stancil, Xiaoqian Ma, Ashley Hernandez-Gutierrez, Jessica N. Becerra, Emilette Marrero-Torres, Corinne E. Hennessy, Kristina Hatakka, Eric P. Wartchow, Alani Estrella, Jonathan P. Huber, Jonathan H. Cardwell, Ellen L. Burnham, Yingze Zhang, Christopher M. Evans, Eszter K. Vladar, David A. Schwartz, Evgenia Dobrinskikh, Ivana V. Yang
Publikováno v:
American journal of respiratory cell and molecular biology. 67(2)
We previously identified a novel molecular subtype of idiopathic pulmonary fibrosis (IPF) defined by increased expression of cilium-associated genes, airway mucin gene
Publikováno v:
Am J Respir Cell Mol Biol
The U.S. Food and Drug Administration–approved proteasomal inhibitor bortezomib (BTZ) has attracted interest for its potential antifibrotic actions. However, neither its in vivo efficacy in lung fibrosis nor its dependence on proteasome inhibition
Autor:
Ru-Jeng Teng, Girija G. Konduri, Ujala Rana, Adeleye J. Afolayan, Abdul K. Parchur, Megha Sharma, Chintamani Joshi, Amit Joshi, Teresa Michalkiewicz
Publikováno v:
Am J Respir Cell Mol Biol
Impaired angiogenesis function in pulmonary artery endothelial cells (PAEC) contributes to persistent pulmonary hypertension of the newborn (PPHN). Decreased nitric oxide (NO) amounts in PPHN lead to impaired mitochondrial biogenesis and angiogenesis
Autor:
Cécile Macquin, Philippe Georgel, Hamid Merdji, Mohamad Kassem, Seiamak Bahram, Kei Kurihara, Aurore De Cauwer, Alicia Sibony, Julie Helms, Chérine Abou Fayçal, Raphaël Clere-Jehl, Laetitia Minniti, Ferhat Meziani
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Septic shock and disseminated intravascular coagulation (DIC) are known to be characterized by an endothelial cell dysfunction. The molecular mechanisms underlying this relationship are, however, poorly understood. In this work, we aimed to investiga
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Pulmonary fibrosis is a progressive and fatal lung disease characterized by activation of lung fibroblasts and excessive deposition of collagen matrix. We show here that the concentrations of kindlin-2 and its binding partner PYCR1, a key enzyme for
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global pandemic. In addition to the acute pulmonary symptoms of coronavirus disease (COVID-19) (the disease associated with SARS-CoV-2 infection), pulmonary and distal
Autor:
Ji Min Li, Wen Hsin Chang, Ssu-Wei Hsu, Shenwen Gu, David C. Yang, Ching-Hsien Chen, Szu Jung Chen
Publikováno v:
Am J Respir Cell Mol Biol
Tobacco smoking is a well-known risk factor for both fibrogenesis and fibrotic progression; however, the mechanisms behind these processes remain enigmatic. RTKs (receptor tyrosine kinases) have recently been reported to drive profibrotic phenotypes
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
TOLLIP (Toll-interacting protein) is an intracellular adaptor protein with diverse actions throughout the body. In a context- and cell type–specific manner, TOLLIP can function as an inhibitor of inflammation and endoplasmic-reticulum stress, an ac
Autor:
Guoqing Qian, Ann Jeffers, Shuzi Owens, Prashant Chauhan, Mitsuo Ikebe, Wenyi Qin, Torry A. Tucker, Steven Idell, Satoshi Komatsu, Xia Guo
Publikováno v:
Am J Respir Cell Mol Biol
Pleural organization may occur after empyema or complicated parapneumonic effusion and can result in restrictive lung disease with pleural fibrosis (PF). Pleural mesothelial cells (PMCs) may contribute to PF through acquisition of a profibrotic pheno
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Right ventricular (RV) function is the predominant determinant of survival in patients with pulmonary arterial hypertension (PAH). In preclinical models, pharmacological activation of BMP (bone morphogenetic protein) signaling with FK506 (tacrolimus)