Zobrazeno 1 - 10
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Autor:
Tina Binesh Marvasti, Faisal J. Alibhai, Shu-Hong Li, Maral Ouzounian, Robert J. Cusimano, Ren-Ke Li, Terrence M. Yau, Jun Wu, Anne Fu, Lukasz Wlodarek, Richard D. Weisel
Publikováno v:
Aging Cell
Ventricular remodeling following myocardial infarction (MI) is a major cause of heart failure, a condition prevalent in older individuals. Following MI, immune cells are mobilized to the myocardium from peripheral lymphoid organs and play an active r
Autor:
Christian Peters, Jérôme Epsztein, Luis G. Aguayo, Rakez Kayed, Denisse Bascuñán, Urmi Sengupta, Peter James Morgan, Nicolas O Riffo-Lepe, Caroline Filippi, Braulio Muñoz, María Paz Espinoza, Romain Bourboulou, Eduardo J Fernández-Pérez
Publikováno v:
Aging Cell
Aging Cell, Wiley Open Access, 2021, ⟨10.1111/acel.13455⟩
Aging Cell, Wiley Open Access, 2021, ⟨10.1111/acel.13455⟩
Intracellular amyloid beta oligomer (iAβo) accumulation and neuronal hyperexcitability are two crucial events at early stages of Alzheimer's disease (AD). However, to date, no mechanism linking iAβo with an increase in neuronal excitability has bee
Publikováno v:
Aging Cell
Although it is known that aging affects neural stem progenitor cell (NSPC) biology in fundamental ways, the underlying dynamics of this process are not fully understood. Our previous work identified a specific critical period (CP) of decline in NSPC
Autor:
Yanli Ding, Andrew Donati, Yuyang Sun, Goutam Ghosh Choudhury, Markus Bitzer, Hak Joo Lee, Kumar Sharma, Christopher L. O’Connor, Muniswamy Madesh, Denis Feliers, Yi Chen, Brij B. Singh, Balakuntalam S. Kasinath, Corinna N. Ross, Wenjun Ju, Adam B. Salmon, Yuji Ikeno
Publikováno v:
Aging Cell
The mechanism of kidney injury in aging are not well understood. In order to identify hitherto unknown pathways of aging‐related kidney injury, we performed RNA‐Seq on kidney extracts of young and aged mice. Expression of chloride (Cl) channel ac
Autor:
Rei Wen Liu, Matthew P. Su, Azusa Kamikouchi, Shih-Peng Chan, Po-Lin Chen, Horng-Dar Wang, Tai Ting Lee, Elena Ziviani, Chun-Hong Chen, Hsueh Fen Juan, Jian Chiuan Li, Jinn Moon Yang, Sophia von Stockum, Yu-Chen Tsai, Yi Wen Chang
Publikováno v:
Aging Cell
Increased levels of dysfunctional mitochondria within skeletal muscle are correlated with numerous age‐related physiopathological conditions. Improving our understanding of the links between mitochondrial function and muscle proteostasis, and the r
Publikováno v:
Aging Cell
Oogenesis is one of the first processes to fail during aging. In women, most oocytes cannot successfully complete meiotic divisions already during the fourth decade of life. Studies of the nematode Caenorhabditis elegans have uncovered conserved gene
Autor:
Yingying Zhao, Yicai Qin, Wei Yu, Zhiqiang Yan, Rongyang Dai, Liangguo Xie, Jinzhong Lin, Dejian Zhou, Xinhua Lin, Qian Qi, Chao Shen, Juan Xing, Yun Qi
Publikováno v:
Aging Cell
Charcot‐Marie‐Tooth disease is the most common inherited peripheral neuropathy. Dominant mutations in the glycyl‐tRNA synthetase (GARS) gene cause peripheral nerve degeneration and lead to CMT disease type 2D. The underlying mechanisms of mutat
Autor:
Wentao Wang, Jingjing You, Jinbo Chen, Haijing Yan, Bin Liu, Linshan Sun, Zhicheng Xu, Fengjiao Sun, Changyun Qiu, Xueli Fan, Dan Wang, Dunjiang Liu, Jiangong Wang
Publikováno v:
Aging Cell
A substantial percentage of late‐life depression patients also have an cognitive impairment, which severely affects the life quality, while the co‐occurring mechanisms are still unclear. Physical exercise can ameliorate both depressive behaviors
Autor:
Patricia Fitzgerald-Bocarsly, Hannah K. Dewald, Utz Herbig, Lisa Gittens-Williams, Themistoklis Vasilopoulos, Ricardo Iván Martínez-Zamudio
Publikováno v:
Aging Cell
Aging leads to a progressive functional decline of the immune system, rendering the elderly increasingly susceptible to disease and infection. The degree to which immune cell senescence contributes to this decline remains unclear, however, since mark
Publikováno v:
Aging Cell
medRxiv
medRxiv
Biological age measures outperform chronological age in predicting various aging outcomes, yet little is known regarding genetic predisposition. We performed genome‐wide association scans of two age‐adjusted biological age measures (PhenoAgeAccel