Zobrazeno 241 - 250
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Autor:
Juan Francisco Morales, Marian Klose, Yannick Hoffert, Jagdeep T. Podichetty, Jackson Burton, Stephan Schmidt, Klaus Romero, Inish O'Doherty, Frank Martin, Martha Campbell‐Thompson, Michael J. Haller, Mark A. Atkinson, Sarah Kim
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1309-1316 (2024)
Abstract Clinical trials seeking to delay or prevent the onset of type 1 diabetes (T1D) face a series of pragmatic challenges. Despite more than 100 years since the discovery of insulin, teplizumab remains the only FDA‐approved therapy to delay pro
Externí odkaz:
https://doaj.org/article/8b4ca31b57414e94973b9675f895a590
Autor:
Alzahra Hamdan, Andrew C. Hooker, Xiaomei Chen, Andreas Traschütz, Rebecca Schüle, ARCA Study Group, EVIDENCE‐RND consortium, Matthis Synofzik, Mats O. Karlsson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1327-1340 (2024)
Abstract The Scale for the Assessment and Rating of Ataxia (SARA) is widely used for assessing the severity and progression of genetic cerebellar ataxias. SARA is now considered a primary end point in several ataxia treatment trials, but its underlyi
Externí odkaz:
https://doaj.org/article/ca2491fc5edd4d2f979817cba54b2637
Autor:
Idris Bachali Losada, Nadia Terranova
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1289-1296 (2024)
Abstract The advent of machine learning has led to innovative approaches in dealing with clinical data. Among these, Neural Ordinary Differential Equations (Neural ODEs), hybrid models merging mechanistic with deep learning models have shown promise
Externí odkaz:
https://doaj.org/article/22561565e7b14bf18a30d7093f17b8bf
Autor:
Raunak Dutta, Aparna Mohan, Jacqueline Buros‐Novik, Gregory Goldmacher, Omobolaji O. Akala, Brian Topp
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1317-1326 (2024)
Abstract Phase Ib trials are common in oncology development but often are not powered for statistical significance. Go/no‐go decisions are largely driven by observed trends in response data. We applied a bootstrapping method to systematically compa
Externí odkaz:
https://doaj.org/article/7906cbcfdc6248e39282ae02750e4a99
Autor:
Arya Pourzanjani, Saurabh Modi, Jamie Connarn, Xinwen Zhang, Vijay Upreti, Chih‐Wei Lin, Khamir Mehta
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1341-1353 (2024)
Abstract Tumor growth inhibition (TGI) modeling attempts to describe the time course changes in tumor size for patients undergoing cancer therapy. TGI models present several advantages over traditional exposure–response models that are based explic
Externí odkaz:
https://doaj.org/article/ce861a043ff0426aa096c733c442f501
Autor:
Conor J. O'Hanlon, Nick Holford, Brian J. Anderson, Mark Greaves, Lee Blackburn, Malcolm D. Tingle, Jacqueline A. Hannam
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1409-1421 (2024)
Abstract Cardiopulmonary bypass (CPB) can alter pharmacokinetic (PK) parameters and the drug may adsorb to the CPB device, altering exposure. Cefazolin is a beta‐lactam antibiotic used for antimicrobial prophylaxis during cardiac surgery supported
Externí odkaz:
https://doaj.org/article/63766ef6483f42269ec7f7107a9503ee
Autor:
E. Niclas Jonsson, Joakim Nyberg
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1297-1308 (2024)
Abstract The full random‐effects model (FREM) is an innovative and relatively novel covariate modeling technique. It differs from other covariate modeling approaches in that it treats covariates as observations and captures their impact on model pa
Externí odkaz:
https://doaj.org/article/cde62fc5c2f84b00a885b4ff89bbc993
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1285-1288 (2024)
Externí odkaz:
https://doaj.org/article/938fdc3706934544ad8786a9d5cb6cab
Autor:
Qiangqiang Liu, Yanqing Cai, Ziyu Mao, Wenze Chen, Bin Chen, Wenzhen Chen, Chencheng Zhang, Yong Lu, Jiwen Xu, Dake He
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 8, Pp 1999-2007 (2024)
Abstract Objective Radiofrequency thermocoagulation (RFTC) has emerged as an effective and safe treatment method for patients with refractory focal epilepsy, when stereo‐electroencephalography (SEEG) is implanted. Although real‐world research res
Externí odkaz:
https://doaj.org/article/31ecd5c683674d049b0c39ae74bc4693
Autor:
Tandis Parvizi, Raphael Wurm, Theresa König, Sara Silvaieh, Patrick Altmann, Sigrid Klotz, Guenther Regelsberger, Tatjana Traub‐Weidinger, Ellen Gelpi, Elisabeth Stögmann
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 8, Pp 1988-1998 (2024)
Abstract Objective In light of clinical trials and disease‐modifying therapies, an early identification of patients at‐risk of developing Alzheimer's disease (AD) is crucial. Blood‐based biomarkers have shown promising results regarding the in
Externí odkaz:
https://doaj.org/article/d24c719dee2e426b8a38d5dd3e56c01e