Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ya-Hsuan Chang"'
Autor:
Ya-Hsuan Chang, Lucille M. Yanckello, George E. Chlipala, Stefan J. Green, Chetan Aware, Amelia Runge, Xin Xing, Anna Chen, Kathryn Wenger, Abeoseh Flemister, Caixia Wan, Ai-Ling Lin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Gut dysbiosis has been identified as a crucial factor of Alzheimer's disease (AD) development for apolipoprotein E4 (APOE4) carriers. Inulin has shown the potential to mitigate dysbiosis. However, it remains unclear whether the dietary respo
Externí odkaz:
https://doaj.org/article/17627065e65e4ee9836fbd65ec622a26
Publikováno v:
Journal of the Formosan Medical Association, Vol 122, Iss 9, Pp 955-960 (2023)
Osimertinib (OSI), a third-generation tyrosine kinase inhibitor (TKI), efficiently benefits lung adenocarcinoma (LUAD) patients with epidermal growth factor receptor (EGFR) mutations. However, combined OSI and immune checkpoint inhibitor in EGFR-muta
Externí odkaz:
https://doaj.org/article/e2852984bde84d8abd26af763a22011f
Autor:
Chih-Hsiang Yu, Ya-Hsuan Chang, Der-Shiun Wang, Shiann-Tarng Jou, Chien-Yu Lin, Kai-Hsin Lin, Meng-Yao Lu, Kang-Hsi Wu, Chao-Neng Cheng, Hsiu-Hao Chang, Shu-Wei Chou, Min-Yu Su, Yu-Ling Ni, Pei-Yuan Xu, Dong-Tsamn Lin, Shu-Wha Lin, Hsuan-Yu Chen, Yung-Li Yang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, especially in t
Externí odkaz:
https://doaj.org/article/006b5d5127924372928e47fbf52676d1
Autor:
Tong‐Hong Wang, Kuo‐Yen Huang, Chin‐Chuan Chen, Ya‐Hsuan Chang, Hsuan‐Yu Chen, Chuen Hsueh, Yi‐Tsen Liu, Shuenn‐Chen Yang, Pan‐Chyr Yang, Chi‐Yuan Chen
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 6, Pp n/a-n/a (2023)
Abstract Particulate matter 2.5 (PM2.5) is a risk factor for lung cancer. In this study, we investigated the molecular mechanisms of PM2.5 exposure on lung cancer progression. We found that short‐term exposure to PM2.5 for 24 h activated the EGFR p
Externí odkaz:
https://doaj.org/article/5e9ebe0cfc3745a7aea86a1c3a1d3ea3
Autor:
Tyler C. Hammond, Elizabeth Powell, Stefan J. Green, George Chlipala, Jacqueline Frank, Andrew T. Yackzan, Lucille M. Yanckello, Ya-Hsuan Chang, Xin Xing, Sally Heil, Joe E. Springer, Keith Pennypacker, Arnold Stromberg, Lumy Sawaki, Ai-Ling Lin
Publikováno v:
Frontiers in Rehabilitation Sciences, Vol 3 (2022)
Accumulating evidence suggests that gut microbes modulate brain plasticity via the bidirectional gut-brain axis and play a role in stroke rehabilitation. However, the microbial species alterations associated with stroke and their correlation with fun
Externí odkaz:
https://doaj.org/article/30c3c7ac5c8b409981a594f053ed8b01
Autor:
Ya-Hsuan Chang, Chih-Hsiang Yu, Shiann-Tarng Jou, Chien-Yu Lin, Kai-Hsin Lin, Meng-Yao Lu, Kang-Hsi Wu, Hsiu-Hao Chang, Dong-Tsamn Lin, Shu-Wha Lin, Hsuan-Yu Chen, Yung-Li Yang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is caused by the accumulation of multiple genetic alterations. To determine the frequency of common genetic mutations and possible prognostic markers in childhood T-ALL, we performed targeted seque
Externí odkaz:
https://doaj.org/article/d6c4e6d2f9484ac082b1174d324876c5
Autor:
Chih-Hao Chang, Arthur Chun-Chieh Shih, Ya-Hsuan Chang, Hsuan‐Yu Chen, Ying-Ting Chao, Yi-Chiung Hsu
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundImmune checkpoint blockade therapy represents an extraordinary advance in lung cancer treatment. It is important to determine the expression of immune checkpoint genes, such as programmed cell death 1 (PD1) and programmed cell death-ligand
Externí odkaz:
https://doaj.org/article/ab7f4b2a36e3433a952411dccc8d8677
Autor:
Yi‐Chiung Hsu, Ya‐Hsuan Chang, Gee‐Chen Chang, Bing‐Ching Ho, Shin‐Sheng Yuan, Yu‐Cheng Li, Jhih‐Wun Zeng, Sung‐Liang Yu, Ker‐Chau Li, Pan‐Chyr Yang, Hsuan‐Yu Chen
Publikováno v:
Cancer Medicine, Vol 8, Iss 5, Pp 2179-2187 (2019)
Abstract Lung cancer is the leading cause of cancer death worldwide and cancer relapse accounts for the majority of cancer mortality. The mechanism is still unknown, especially in hereditary lung cancer without known actionable mutations. To identify
Externí odkaz:
https://doaj.org/article/dea9fc3e6a404ff7a50d41402858c0ca
Autor:
Chia-Sing Lu, Ching-Wen Lin, Ya-Hsuan Chang, Hsuan-Yu Chen, Wei-Chia Chung, Wei-Yun Lai, Chao-Chi Ho, Tong-Hong Wang, Chi-Yuan Chen, Chen-Lin Yeh, Sean Wu, Shu-Ping Wang, Pan-Chyr Yang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The immune checkpoint blockade (ICB) targeting programmed cell death-1 (PD-1) and its ligand (PD-L1) has been proved beneficial for numerous types of cancers, including non-small-cell lung cancer (NSCLC). However, a significant number of p
Externí odkaz:
https://doaj.org/article/0dfe9936eb494d85b30885d230a8aa46
Autor:
Ching-Wen Lin, Lu-Kai Wang, Shu-Ping Wang, Yih-Leong Chang, Yi-Ying Wu, Hsuan-Yu Chen, Tzu-Hung Hsiao, Wei-Yun Lai, Hsuan-Hsuan Lu, Ya-Hsuan Chang, Shuenn-Chen Yang, Ming-Wei Lin, Chi-Yuan Chen, Tse-Ming Hong, Pan-Chyr Yang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Hypoxia and epithelial-to-mesenchymal transition promotes cancer metastasis. Here the authors show that Daxx inhibits hypoxia-induced lung cancer metastasis by attenuating Slug-mediated transcriptional repression of epithelial-like markers that in tu
Externí odkaz:
https://doaj.org/article/7aa2a547a6274b01b109ab20da77c6cb