Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Verena Sailer"'
Aggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiation
Autor:
Lina Merkens, Verena Sailer, Davor Lessel, Ella Janzen, Sarah Greimeier, Jutta Kirfel, Sven Perner, Klaus Pantel, Stefan Werner, Gunhild von Amsberg
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-20 (2022)
Abstract Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against androgen synthesis or AR activation is broadly used and continual
Externí odkaz:
https://doaj.org/article/af616c4e41df4e3faad5f2ada80aa9e5
Autor:
Amelie von Bernuth, Julika Ribbat-Idel, Luise Klapper, Tobias Jagomast, Dirk Rades, Anke Leichtle, Ralph Pries, Karl-Ludwig Bruchhage, Sven Perner, Anne Offermann, Verena Sailer, Christian Idel
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5140 (2023)
Patients with head and neck squamous cell carcinoma (HNSCC) continue to have a rather poor prognosis. Treatment-related comorbidities have negative impacts on their quality of life. TRIM21 is a cytosolic E3 ubiquitin ligase that was initially describ
Externí odkaz:
https://doaj.org/article/d53dda13074743db9b9dc6e14bf6e46b
Autor:
Jacqueline Fontugne, Peter Y. Cai, Hussein Alnajar, Bhavneet Bhinder, Kyung Park, Huihui Ye, Shaham Beg, Verena Sailer, Javed Siddiqui, Mirjam Blattner-Johnson, Jaclyn A. Croyle, Zohal Noorzad, Carla Calagua, Theresa Y. MacDonald, Ulrika Axcrona, Mari Bogaard, Karol Axcrona, Douglas S. Scherr, Martin G. Sanda, Bjarne Johannessen, Arul M. Chinnaiyan, Olivier Elemento, Rolf I. Skotheim, Mark A. Rubin, Christopher E. Barbieri, Juan Miguel Mosquera
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
BACKGROUND Prostate cancer is multifocal with distinct molecular subtypes. The utility of genomic subtyping has been challenged due to inter- and intrafocal heterogeneity. We sought to characterize the subtype-defining molecular alterations of primar
Externí odkaz:
https://doaj.org/article/c79b0c37b3564a8a9e8aad713f06f212
Autor:
Verena Sailer, Ulrike Sailer, Emma Grace Bawden, Romina Zarbl, Constanze Wiek, Timo J. Vogt, Joern Dietrich, Sophia Loick, Ingela Grünwald, Marieta Toma, Carsten Golletz, Andreas Gerstner, Glen Kristiansen, Friedrich Bootz, Kathrin Scheckenbach, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 341-352 (2019)
Background: The immune checkpoint, indoleamine 2,3-dioxygenase 1, is under investigation as target of novel immunotherapies for cancers, including head and neck squamous cell carcinomas (HNSCC). The aim of our study was to analyze DNA methylation of
Externí odkaz:
https://doaj.org/article/19f13459f3a443e282ec3bbaa5759ff0
Autor:
Christiane Kuempers, Tobias Jagomast, Rosemarie Krupar, Finn-Ole Paulsen, Carsten Heidel, Julika Ribbat-Idel, Christian Idel, Bruno Märkl, Martin Anlauf, Sabina Berezowska, Markus Tiemann, Hans Bösmüller, Falko Fend, Barbara Kalsdorf, Sabine Bohnet, Eva Dreyer, Verena Sailer, Jutta Kirfel, Sven Perner
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Rovalpituzumab tesirine (Rova-T), an antibody-drug conjugate directed against Delta-like protein 3 (DLL3), is under development for patients with small cell lung cancer (SCLC). DLL3 is expressed on the majority of SCLC samples. Because SCLC is rarely
Externí odkaz:
https://doaj.org/article/2f2a6251c4574098908108fee406f2a3
Autor:
Alireza Saraji, Kang Duan, Christian Watermann, Katharina Hempel, Marie C. Roesch, Rosemarie Krupar, Janine Stegmann-Frehse, Danny Jonigk, Mark Philipp Kuehnel, Wolfram Klapper, Axel S. Merseburger, Jutta Kirfel, Sven Perner, Anne Offermann, Verena Sailer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13029 (2022)
Bone metastatic (BM) prostate cancer (PCa) belongs to the most lethal form of PCa, and therapeutic options are limited. Molecular profiling of metastases contributes to the understanding of mechanisms defining the bone metastatic niche. Our aim was t
Externí odkaz:
https://doaj.org/article/5722d2c076dd4b6783f6361a94770381
Autor:
Anna-Lena Lemster, Elisabeth Sievers, Helen Pasternack, Pamela Lazar-Karsten, Niklas Klümper, Verena Sailer, Anne Offermann, Johannes Brägelmann, Sven Perner, Jutta Kirfel
Publikováno v:
Cancers, Vol 14, Iss 8, p 1894 (2022)
Prostate cancer (PCa) poses a major public health problem in men. Metastatic PCa is incurable, and ultimately threatens the life of many patients. Mutations in tumor suppressor genes and oncogenes are important for PCa progression, whereas the role o
Externí odkaz:
https://doaj.org/article/b6199af1803c4b2386a3dff6799ee988
Autor:
Alireza Saraji, Anne Offermann, Janine Stegmann-Frehse, Katharina Hempel, Duan Kang, Rosemarie Krupar, Christian Watermann, Danny Jonigk, Mark Philipp Kühnel, Jutta Kirfel, Sven Perner, Verena Sailer
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257416 (2021)
With the advance of precision medicine, the availability of tumor tissue for molecular analysis has become a limiting factor. This is particularly the case for bone metastases which are frequently occurring in cancer types such as prostate cancer. Du
Externí odkaz:
https://doaj.org/article/1e828c583f6242608f0c9b44085808a4
Autor:
Loredana Puca, Rohan Bareja, Davide Prandi, Reid Shaw, Matteo Benelli, Wouter R. Karthaus, Judy Hess, Michael Sigouros, Adam Donoghue, Myriam Kossai, Dong Gao, Joanna Cyrta, Verena Sailer, Aram Vosoughi, Chantal Pauli, Yelena Churakova, Cynthia Cheung, Lesa Dayal Deonarine, Terra J. McNary, Rachele Rosati, Scott T. Tagawa, David M. Nanus, Juan Miguel Mosquera, Charles L. Sawyers, Yu Chen, Giorgio Inghirami, Rema A. Rao, Carla Grandori, Olivier Elemento, Andrea Sboner, Francesca Demichelis, Mark A. Rubin, Himisha Beltran
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
There are few available models to study neuroendocrine prostate cancer. Here they develop and characterize patient derived organoids from metastatic lesions, use these models to show the role of EZH2 in driving neuroendocrine phenotype, and perform h
Externí odkaz:
https://doaj.org/article/6298c3191ca44642a1ee5adc286008a4
Autor:
Marie Christine Hupe, Christian Philippi, Doris Roth, Christiane Kümpers, Julika Ribbat-Idel, Finn Becker, Vincent Joerg, Stefan Duensing, Verena Helena Lubczyk, Jutta Kirfel, Verena Sailer, Rainer Kuefer, Axel Stuart Merseburger, Sven Perner, Anne Offermann
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Background: Stratifying prostate cancer (PCa) patients into risk groups at time of initial diagnosis enabling a risk-adapted disease management is still a major clinical challenge. Existing studies evaluating the prognostic potential of PSMA (prostat
Externí odkaz:
https://doaj.org/article/801aceec93424ec09fe9709e7a826e2f