Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Takeharu Kunieda"'
Autor:
Yuki Takahashi, Naoya Oishi, Yukihiro Yamao, Takeharu Kunieda, Takayuki Kikuchi, Hidenao Fukuyama, Susumu Miyamoto, Yoshiki Arakawa
Publikováno v:
Brain and Behavior, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Introduction Meningiomas are the most common primary central nervous system tumors. Predicting the grade and proliferative activity of meningiomas would influence therapeutic strategies. We aimed to apply the multiple parameters from preoper
Externí odkaz:
https://doaj.org/article/677348d7bd7046ec999fb7257492d49e
Autor:
Akihiro Inoue, Takanori Ohnishi, Masahiro Nishikawa, Yoshihiro Ohtsuka, Kosuke Kusakabe, Hajime Yano, Junya Tanaka, Takeharu Kunieda
Publikováno v:
Cancers, Vol 15, Iss 19, p 4898 (2023)
High invasiveness is a characteristic of glioblastoma (GBM), making radical resection almost impossible, and thus, resulting in a tumor with inevitable recurrence. GBM recurrence may be caused by glioma stem-like cells (GSCs) that survive many kinds
Externí odkaz:
https://doaj.org/article/2f9c94b08f5645af84e78cb3155f3ef8
Autor:
Akihiro Inoue, Takanori Ohnishi, Masahiro Nishikawa, Hideaki Watanabe, Kosuke Kusakabe, Mashio Taniwaki, Hajime Yano, Yoshihiro Ohtsuka, Shirabe Matsumoto, Satoshi Suehiro, Daisuke Yamashita, Seiji Shigekawa, Hisaaki Takahashi, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2369 (2023)
Recurrent glioblastoma multiforme (GBM) is largely attributed to peritumoral infiltration of tumor cells. As higher CD44 expression in the tumor periphery correlates with higher risk of GBM invasion, the present study analyzed the relationship betwee
Externí odkaz:
https://doaj.org/article/44706f2a476847e3abcc2f9a4dfed5f5
Autor:
Masaya Togo, Riki Matsumoto, Kiyohide Usami, Katsuya Kobayashi, Hirofumi Takeyama, Takuro Nakae, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Masao Matsuhashi, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
Publikováno v:
NeuroImage, Vol 263, Iss , Pp 119639- (2022)
The medial parietal cortices are components of the default mode network (DMN), which are active in the resting state. The medial parietal cortices include the precuneus and the dorsal posterior cingulate cortex (dPCC). Few studies have mentioned diff
Externí odkaz:
https://doaj.org/article/3213dffa6df444ce9f3c28bbccca82d9
Autor:
Saya Ozaki, Akihiro Umakoshi, Hajime Yano, Shota Ohsumi, Yutaro Sumida, Erika Hayase, Eika Usa, Afsana Islam, Mohammed E. Choudhury, Yusuke Nishi, Daisuke Yamashita, Yoshihiro Ohtsuka, Masahiro Nishikawa, Akihiro Inoue, Satoshi Suehiro, Jun Kuwabara, Hideaki Watanabe, Yasutsugu Takada, Yuji Watanabe, Ichiro Nakano, Takeharu Kunieda, Junya Tanaka
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 8, Pp 754-765 (2021)
The abilities to invade surrounding tissues and metastasize to distant organs are the most outstanding features that distinguish malignant from benign tumors. However, the mechanisms preventing the invasion and metastasis of benign tumor cells remain
Externí odkaz:
https://doaj.org/article/b56b30c37d804d6299ad8d65387f3147
Autor:
Shirabe Matsumoto, Mohammed E. Choudhury, Haruna Takeda, Arisa Sato, Nanako Kihara, Kanta Mikami, Akihiro Inoue, Hajime Yano, Hideaki Watanabe, Yoshiaki Kumon, Takeharu Kunieda, Junya Tanaka
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Ischemic stroke is a leading cause of mortality and permanent disability. Chronic stroke lesions increase gradually due to the secondary neuroinflammation that occurs following acute ischemic neuronal degeneration. In this study, the ameliorating eff
Externí odkaz:
https://doaj.org/article/4ecd7bcc070346809c94f2c50fc1e634
Autor:
Masahiro Nishikawa, Akihiro Inoue, Takanori Ohnishi, Hajime Yano, Yonehiro Kanemura, Shohei Kohno, Shiro Ohue, Saya Ozaki, Shirabe Matsumoto, Satoshi Suehiro, Yawara Nakamura, Seiji Shigekawa, Hideaki Watanabe, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda
Publikováno v:
Cancer Medicine, Vol 10, Iss 6, Pp 2013-2025 (2021)
Abstract Antiangiogenic therapy with bevacizumab (Bev), a monoclonal antibody targeting vascular endothelial growth factor (VEGF), is a common treatment for recurrent glioblastoma (GBM), but its survival benefit is limited. Resistance to Bev is thoug
Externí odkaz:
https://doaj.org/article/c9c9b0ba3246479ab1c5326b3e7cd505
Autor:
Mohammed E. Choudhury, Saya Ozaki, Noriyuki Miyaue, Taisei Matsuura, Kanta Mikami, Afsana Islam, Madoka Kubo, Rina Ando, Hajime Yano, Takeharu Kunieda, Masahiro Nagai, Junya Tanaka
Publikováno v:
Brain Sciences, Vol 13, Iss 1, p 55 (2022)
Activated microglia potentially cause neurodegeneration in Parkinson’s disease (PD). Matrix metalloproteinase (MMP)-9 plays a crucial role in the pathogenesis of PD, but the modulator of microglial release of MMP-9 remains obscure. Given the modula
Externí odkaz:
https://doaj.org/article/39b91d4a0d7b4387b7e6242fa12d6833
Autor:
Timothy T Rogers, Christopher R Cox, Qihong Lu, Akihiro Shimotake, Takayuki Kikuchi, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda, Riki Matsumoto, Matthew A Lambon Ralph
Publikováno v:
eLife, Vol 10 (2021)
How does the human brain encode semantic information about objects? This paper reconciles two seemingly contradictory views. The first proposes that local neural populations independently encode semantic features; the second, that semantic representa
Externí odkaz:
https://doaj.org/article/0e9ecb72e967480abc494904f3b3b7a8
Publikováno v:
Cancers, Vol 14, Iss 19, p 4890 (2022)
CLICs are the dimorphic protein present in both soluble and membrane fractions. As an integral membrane protein, CLICs potentially possess ion channel activity. However, it is not fully clarified what kinds of roles CLICs play in physiological and pa
Externí odkaz:
https://doaj.org/article/0da6ff26f9564dd580f09e1c1a3aa467