Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Rudolph L. Leibel"'
Autor:
Na Zhu, Charles A. LeDuc, Ilene Fennoy, Blandine Laferrère, Claudia A. Doege, Yufeng Shen, Wendy K. Chung, Rudolph L. Leibel
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-6 (2023)
Abstract Bassoon (BSN) is a component of a hetero-dimeric presynaptic cytomatrix protein that orchestrates neurotransmitter release with Piccolo (PCLO) from glutamatergic neurons throughout the brain. Heterozygous missense variants in BSN have previo
Externí odkaz:
https://doaj.org/article/6543f71e19a84a35b2f1e186100612b8
Autor:
Yuwei Zhang, Lina Sui, Qian Du, Leena Haataja, Yishu Yin, Ryan Viola, Shuangyi Xu, Christian Ulrik Nielsson, Rudolph L. Leibel, Fabrizio Barbetti, Peter Arvan, Dieter Egli
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101879- (2024)
Objective: Heterozygous coding sequence mutations of the INS gene are a cause of permanent neonatal diabetes (PNDM), requiring insulin therapy similar to T1D. While the negative effects on insulin processing and secretion are known, how dominant insu
Externí odkaz:
https://doaj.org/article/8fce543b22c7434f8a6ea4fc5678ee55
Autor:
Bryan J. González, Haoquan Zhao, Jacqueline Niu, Damian J. Williams, Jaeyop Lee, Chris N. Goulbourne, Yuan Xing, Yong Wang, Jose Oberholzer, Maria H. Blumenkrantz, Xiaojuan Chen, Charles A. LeDuc, Wendy K. Chung, Henry M. Colecraft, Jesper Gromada, Yufeng Shen, Robin S. Goland, Rudolph L. Leibel, Dieter Egli
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
hPSCs model of Maturity Onset Diabetes of the Young caused by mutations in the transcription factor HNF1A (HNF1A-MODY), regulates the expression of genes required for the formation of dense-core insulin granules and calcium-dependent insulin secretio
Externí odkaz:
https://doaj.org/article/aaec8b98bed94ed097cfc4ed5a54e814
Autor:
Yun-Kyoung Lee, Wen Du, Yaohui Nie, Bryan Diaz, Nishat Sultana, Takumi Kitamoto, Rudolph L. Leibel, Domenico Accili, Sandro Belvedere
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101618- (2022)
Objectives: Insulin treatment remains the sole effective intervention for Type 1 Diabetes. Here, we investigated the therapeutic potential of converting intestinal epithelial cells to insulin-producing, glucose-responsive β-like cells by targeted in
Externí odkaz:
https://doaj.org/article/5b916d96958240c9a77147b77b3d5577
Autor:
Takumi Kitamoto, Yun-Kyoung Lee, Nishat Sultana, Hitoshi Watanabe, Wendy M. McKimpson, Wen Du, Jason Fan, Bryan Diaz, Hua V. Lin, Rudolph L. Leibel, Sandro Belvedere, Domenico Accili
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101624- (2022)
Objective: Lifelong insulin replacement remains the mainstay of type 1 diabetes treatment. Genetic FoxO1 ablation promotes enteroendocrine cell (EECs) conversion into glucose-responsive β-like cells. Here, we tested whether chemical FoxO1 inhibitors
Externí odkaz:
https://doaj.org/article/df93c47e5c174cc68dabf3af76c69142
Autor:
Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, Sumei Lu, Rick Rausch, James A. Pippin, Maria Caterina De Rosa, Alisha Basak, Jonathan P. Bradfield, Reza K. Hammond, Keith Boehm, Robert I. Berkowitz, Chiara Lasconi, Chun Su, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F. A. Grant
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Understanding the genetic regulation of hypothalamic function could yield insights into disease pathogenesis, but its inaccessibility has made this challenging. Here the authors present a high-resolution chromatin atlas of a hypothalamic-like neuron
Externí odkaz:
https://doaj.org/article/87b561b18c73423d8f4af95c3968229a
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
We have recently shown that physiological delay can induce a novel form of sustained temporal chaos we call delay-induced uncertainty (DIU) (Karamched et al. (Chaos, 2021, 31, 023142)). This paper assesses the impact of DIU on the ability of the gluc
Externí odkaz:
https://doaj.org/article/47c71ef13d7441b3b0831784fd6c6ae8
Autor:
Chiara Lasconi, Matthew C. Pahl, Diana L. Cousminer, Claudia A. Doege, Alessandra Chesi, Kenyaita M. Hodge, Michelle E. Leonard, Sumei Lu, Matthew E. Johnson, Chun Su, Reza K. Hammond, James A. Pippin, Natalie A. Terry, Louis R. Ghanem, Rudolph L. Leibel, Andrew D. Wells, Struan F.A. Grant
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 667-682 (2021)
Background & Aims: Inflammatory bowel disease (IBD) is a polygenic disorder characterized principally by dysregulated inflammation impacting the gastrointestinal tract. However, there also is increasing evidence for a clinical association with stress
Externí odkaz:
https://doaj.org/article/5ea732da22e64125aa7a08b992a12fda
Autor:
Claudia Lugo‐Candelas, Yajing Pang, Seonjoo Lee, Jiook Cha, Susie Hong, Lisa Ranzenhofer, Rachel Korn, Haley Davis, Hailey McInerny, Janet Schebendach, Wendy K. Chung, Rudolph L. Leibel, B. Timothy Walsh, Jonathan Posner, Michael Rosenbaum, Laurel Mayer
Publikováno v:
Obesity Science & Practice, Vol 6, Iss 4, Pp 409-424 (2020)
Summary Objective Noncoding alleles of the fat mass and obesity‐associated (FTO) gene have been associated with obesity risk, yet the underlying mechanisms remain unknown. Risk allele carriers show alterations in brain structure and function, but p
Externí odkaz:
https://doaj.org/article/32d56b801d8e44ee90cbe58ab5504a20
Autor:
Maria Caterina De Rosa, Hannah J. Glover, George Stratigopoulos, Charles A. LeDuc, Qi Su, Yufeng Shen, Mark W. Sleeman, Wendy K. Chung, Rudolph L. Leibel, Judith Y. Altarejos, Claudia A. Doege
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Energy balance is controlled by interconnected brain regions in the hypothalamus, brainstem, cortex, and limbic system. Gene expression signatures of these regions can help elucidate the pathophysiology underlying obesity. RNA sequencing was conducte
Externí odkaz:
https://doaj.org/article/ee350ea6a47341e992a1ee06fdf5670e