Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mitsuhiko Ikura"'
Autor:
Teklab Gebregiworgis, Jonathan Yui-Lai Chan, Douglas A. Kuntz, Gilbert G. Privé, Christopher B. Marshall, Mitsuhiko Ikura
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151414- (2024)
The RAS isoforms (KRAS, HRAS and NRAS) have distinct cancer type-specific profiles. NRAS mutations are the second most prevalent RAS mutations in skin and hematological malignancies. Although RAS proteins were considered undruggable for decades, isof
Externí odkaz:
https://doaj.org/article/3a8df14dd4c348f6b90cd509a98b511e
Autor:
Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L. Udaskin, Ahmet Mentes, Richard Huang, Betty P. K. Poon, Wenguang He, Ivette Valencia-Sama, Claire M. Robinson, Melissa Huestis, Jinmin Miao, Jen Jen Yeh, Zhong-Yin Zhang, Meredith S. Irwin, Jeffrey E. Lee, Ming-Sound Tsao, Brian Raught, Christopher B. Marshall, Michael Ohh, Mitsuhiko Ikura
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
SHP2 promotes RAS-driven MAPK signalling, but it is unclear why cancer cells with distinct KRAS mutations exhibit differential sensitivity to SHP2 inhibition. Here the authors show that KRAS Q61H is decoupled from SHP2- mediated upstream regulation,
Externí odkaz:
https://doaj.org/article/adc5eaa39af340409424aef1fcf1144b
Autor:
Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Nikolina Radulovich, Betty P. K. Poon, Jonathan St-Germain, Jonathan D. Cook, Ivette Valencia-Sama, Benjamin M. M. Grant, Silvia Gabriela Herrera, Jinmin Miao, Brian Raught, Meredith S. Irwin, Jeffrey E. Lee, Jen Jen Yeh, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura, Michael Ohh
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Deregulation of the RAS GTPase cycle due to mutations in RAS genes is commonly associated with cancer development. Here authors use NMR and mass spectrometry to shows that KRAS phosphorylation via Src alters the conformation of switch I and II region
Externí odkaz:
https://doaj.org/article/811fdf81e7164853822f6750cc8b6260
Autor:
Noboru Ishiyama, Ritu Sarpal, Megan N. Wood, Samantha K. Barrick, Tadateru Nishikawa, Hanako Hayashi, Anna B. Kobb, Annette S. Flozak, Alex Yemelyanov, Rodrigo Fernandez-Gonzalez, Shigenobu Yonemura, Deborah E. Leckband, Cara J. Gottardi, Ulrich Tepass, Mitsuhiko Ikura
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Cell-cell adhesion mediated by catenin-cadherin complexes plays a critical role in translating the mechanical forces into physiological responses. Here the authors define a mechanism of force-dependent cadherin-actin linkage dynamically regulated thr
Externí odkaz:
https://doaj.org/article/811fe916ab7f4aa8a28b241ddb5f61db
Autor:
Minoru Inoue, Ryota Nakashima, Masahiro Enomoto, Yuhki Koike, Xiao Zhao, Kenneth Yip, Shao Hui Huang, John N. Waldron, Mitsuhiko Ikura, Fei-Fei Liu, Scott V. Bratman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Neutrophil extracellular traps (NETs) are known to promote metastasis in mouse models. Here the authors show plasma redox imbalance caused by albumin oxidation to induce inflammation-independent NETosis and lung metastasis, and albumin oxidation and
Externí odkaz:
https://doaj.org/article/22fe89aefc79448c91736fa156901f56
Autor:
Qingci Zhao, Ryu Fujimiya, Satoshi Kubo, Christopher B. Marshall, Mitsuhiko Ikura, Ichio Shimada, Noritaka Nishida
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108074- (2020)
Summary: The small guanosine triphosphatase (GTPase) RAS serves as a molecular switch in signal transduction, and its mutation and aberrant activation are implicated in tumorigenesis. Here, we perform real-time, in-cell nuclear magnetic resonance (NM
Externí odkaz:
https://doaj.org/article/3d6fd00452384208b42d869f9e334cbc
Autor:
Matthew J. Smith, Elizabeth Ottoni, Noboru Ishiyama, Marilyn Goudreault, André Haman, Claus Meyer, Monika Tucholska, Genevieve Gasmi-Seabrook, Serena Menezes, Rob C. Laister, Mark D. Minden, Rolf Marschalek, Anne-Claude Gingras, Trang Hoang, Mitsuhiko Ikura
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Several rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.
Externí odkaz:
https://doaj.org/article/8e1f5d31a64445fb84962ab9b91f057b
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2751 (2020)
Calmodulin (CaM) is a Ca2+-sensor that regulates a wide variety of target proteins, many of which interact through short basic helical motifs bearing two hydrophobic ‘anchor’ residues. CaM comprises two globular lobes, each containing a pair of E
Externí odkaz:
https://doaj.org/article/9cec5698016b4bbeba0bddf148e3cbbe
Autor:
Shawna L Organ, Josephine Hai, Nikolina Radulovich, Christopher B Marshall, Lisa Leung, Takehiko Sasazuki, Senji Shirasawa, Chang-Qi Zhu, Roya Navab, Mitsuhiko Ikura, Ming-Sound Tsao
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86103 (2014)
KRAS is mutated in ∼40% of colorectal cancer (CRC), and there are limited effective treatments for advanced KRAS mutant CRC. Therefore, it is crucial that downstream mediators of oncogenic KRAS continue to be studied. We identified p190RhoGAP as be
Externí odkaz:
https://doaj.org/article/6d72e1f7b48344a7af4bccae51d2c420