Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Li-Bin Pan"'
Autor:
Zheng-Wei Zhang, Chun-Sheng Gao, Heng Zhang, Jian Yang, Ya-Ping Wang, Li-Bin Pan, Hang Yu, Chi-Yu He, Hai-Bin Luo, Zhen-Xiong Zhao, Xin-Bo Zhou, Yu-Li Wang, Jie Fu, Pei Han, Yu-Hui Dong, Gang Wang, Song Li, Yan Wang, Jian-Dong Jiang, Wu Zhong
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 8, Pp 3298-3312 (2022)
Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted
Externí odkaz:
https://doaj.org/article/550caaf00dce49ea8a24e4a2f2b15517
Autor:
Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang
Publikováno v:
Engineering, Vol 15, Iss , Pp 115-125 (2022)
Due to the worldwide epidemic of allergic disease and a cure nowhere in sight, there is a crucial need to explore its pathophysiological mechanisms. As allergic disease has been associated with gut dysbiosis, we searched for a possible mechanism from
Externí odkaz:
https://doaj.org/article/42b19f2a0ca74c60b0d9632d930cd0a3
Autor:
Shu-Rong Ma, Qian Tong, Yuan Lin, Li-Bin Pan, Jie Fu, Ran Peng, Xian-Feng Zhang, Zhen-Xiong Zhao, Yang Li, Jin-Bo Yu, Lin Cong, Pei Han, Zheng-Wei Zhang, Hang Yu, Yan Wang, Jian-Dong Jiang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Trimethylamine-N-oxide (TMAO) derived from the gut microbiota is an atherogenic metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO production in the gut microbiota and treat atherosclerosis. Effects of BBR o
Externí odkaz:
https://doaj.org/article/7b23508107ec49a1b8a97d37f510e106
Autor:
Zheng-Wei Zhang, Lin Cong, Ran Peng, Pei Han, Shu-Rong Ma, Li-Bin Pan, Jie Fu, Hang Yu, Yan Wang, Jian-Dong Jiang
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 11, Iss 5, Pp 628-637 (2021)
Berberine (BBR) is an isoquinoline alkaloid extracted from Coptis chinensis that improves diabetes, hyperlipidemia and inflammation. Due to the low oral bioavailability of BBR, its mechanism of action is closely related to the gut microbiota. This st
Externí odkaz:
https://doaj.org/article/3b7e702947c84d89a4da1c3fba616b7c
Autor:
Hui Xu, Li-Bin Pan, Hang Yu, Pei Han, Jie Fu, Zheng-Wei Zhang, Jia-Chun Hu, Xin-Yu Yang, Adili Keranmu, Hao-Jian Zhang, Meng-Meng Bu, Jian-Dong Jiang, Yan Wang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The gut microbiota plays an important role in inflammatory diseases. Metabolites in the three metabolic pathways of tryptophan (Trp), histidine (His), and phenylalanine (Phe) can affect various inflammatory conditions, such as obesity, diabetes, arth
Externí odkaz:
https://doaj.org/article/7898b012f74941248f153964d27ed717
Autor:
Ran Peng, Pei Han, Jie Fu, Zheng-Wei Zhang, Shu-Rong Ma, Li-Bin Pan, Yuan-Yuan Xia, Hang Yu, Hui Xu, Chang-Xiao Liu, Yan Wang
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Bifidobacteria is an important microbe that inhabits the human gut. It is capable of metabolizing complex compounds in the human diet. Albiflorin, an antidepressant natural product from Radix Paeoniae Alba in China, is difficult to absorb after oral
Externí odkaz:
https://doaj.org/article/19ccdd803e594807a962f7ac7c815454
Autor:
Yan Wang, Qian Tong, Shu-Rong Ma, Zhen-Xiong Zhao, Li-Bin Pan, Lin Cong, Pei Han, Ran Peng, Hang Yu, Yuan Lin, Tian-Le Gao, Jia-Wen Shou, Xiao-Yang Li, Xian-Feng Zhang, Zheng-Wei Zhang, Jie Fu, Bao-Ying Wen, Jin-Bo Yu, Xuetao Cao, Jian-Dong Jiang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-20 (2021)
Abstract The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In this process, tyrosine hydroxylase (TH) is the rate-limiting enzyme that hydroxylates tyrosine and generates levodopa (l-dopa) with tetrahydrobiopterin
Externí odkaz:
https://doaj.org/article/678b44e28f764ee2b9cc1ea4d69df7da
Autor:
Hang Yu, Jie Fu, Hui-Hui Guo, Li-Bin Pan, Hui Xu, Zheng-Wei Zhang, Jia-Chun Hu, Xin-Yu Yang, Hao-Jian Zhang, Meng-Meng Bu, Yuan Lin, Jian-Dong Jiang, Yan Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7457 (2022)
Saussurea involucrata has been reported to have potential therapeutic effects against myocardial ischemia. The pharmacological effects of oral natural medicines may be influenced by the participation of gut microbiota. In this study, we aimed to inve
Externí odkaz:
https://doaj.org/article/5e6f9a1072ba466e94f67e3205168e96
Autor:
Adili Keranmu, Li-Bin Pan, Jie Fu, Pei Han, Hang Yu, Zheng-Wei Zhang, Hui Xu, Xin-Yu Yang, Jia-Chun Hu, Hao-Jian Zhang, Meng-Meng Bu, Jian-Dong Jiang, Nian-Zeng Xing, Yan Wang
Publikováno v:
Molecules, Vol 27, Iss 10, p 3057 (2022)
The bioavailability of flavonoids is generally low after oral administration. The metabolic transformation of flavonoids by the gut microbiota may be one of the main reasons for this, although these metabolites have potential pharmacological activiti
Externí odkaz:
https://doaj.org/article/c6f542fb96cb4798aecb11f33c89198e
Autor:
Guo-Ming Dong, Hang Yu, Li-Bin Pan, Shu-Rong Ma, Hui Xu, Zheng-Wei Zhang, Pei Han, Jie Fu, Xin-Yu Yang, Adili Keranmu, Hai-Tao Niu, Jian-Dong Jiang, Yan Wang
Publikováno v:
Molecules, Vol 26, Iss 13, p 3861 (2021)
Timosaponin BII is one of the most abundant Anemarrhena saponins and is in a phase II clinical trial for the treatment of dementia. However, the pharmacological activity of timosaponin BII does not match its low bioavailability. In this study, we aim
Externí odkaz:
https://doaj.org/article/d8c18dfedc9c40f3ae1aebb37edebf23